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Section edited by Jean-Francois Beaulieu
This section will consider submissions that focus on the analysis of gene expression levels and patterns, transcription mechanisms and the regulation of transcription.
Methodology article
Formalin-fixed paraffin embedded (FFPE) tissue constitutes a vast treasury of samples for biomedical research. Thus far however, extraction of RNA from FFPE tissue has proved challenging due to chemical RNA–pr...
BMC Molecular Biology 2017 18:22
Published on: 23 August 2017
Research article
Nuclear factors of activated T-cells (NFATs) have been mainly characterized in the context of immune response regulation because, as transcription factors, they have the ability to induce gene transcription. N...
BMC Molecular Biology 2017 18:20
Published on: 3 August 2017
Research article
Growth arrest specific 2 (gas2) gene is a component of the microfilament system that plays a major role in the cell cycle, regulation of microfilaments, and cell morphology during apoptotic processes. However, li...
BMC Molecular Biology 2017 18:18
Published on: 17 July 2017
Research article
G-quadruplex is a DNA secondary structure that has been shown to play an important role in biological systems. In a previous study, we identified 1998 G-quadruplex-forming sequences using a mouse CpG islands D...
BMC Molecular Biology 2017 18:17
Published on: 27 June 2017
Research article
Mitogenome diversity is staggering among early branching animals with respect to size, gene density, content and order, and number of tRNA genes, especially in cnidarians. This last point is of special interes...
BMC Molecular Biology 2017 18:16
Published on: 17 June 2017
Research article
The denervated hippocampus provides a proper microenvironment for the survival and neuronal differentiation of neural progenitors. While thousands of lncRNAs were identified, only a few lncRNAs that regulate n...
BMC Molecular Biology 2017 18:15
Published on: 6 June 2017
Research article
Along with sodium/calcium (Ca2+) exchangers, plasma membrane Ca2+ ATPases (ATP2Bs) are main regulators of intracellular Ca2+ levels. There are four ATP2B paralogs encoded by four different genes. Atp2b2 encodes t...
BMC Molecular Biology 2017 18:14
Published on: 22 May 2017
Research article
Prevalence of fibroproliferative diseases, including chronic kidney disease is rapidly increasing and has become a major public health problem worldwide. Fibroproliferative diseases are characterized by increa...
BMC Molecular Biology 2017 18:12
Published on: 27 April 2017
Research article
Oxidative stress can induce cell injury in vascular endothelial cells, which is the initial event in the development of atherosclerosis. Although quantitative real-time polymerase chain reaction (qRT-PCR) has ...
BMC Molecular Biology 2017 18:10
Published on: 5 April 2017
Research article
SPI1 is an essential transcription factor (TF) for the hematopoietic lineage, in which its expression is tightly controlled through a −17-kb upstream regulatory region and a promoter region. Both regulatory re...
BMC Molecular Biology 2017 18:9
Published on: 4 April 2017
The Erratum to this article has been published in BMC Molecular Biology 2017 18:11
Research article
STAT1 and IRF1 collaborate to induce interferon-γ (IFNγ) stimulated genes (ISGs), but the extent to which they act alone or together is unclear. The effect of single nucleotide polymorphisms (SNPs) on in vivo ...
BMC Molecular Biology 2017 18:6
Published on: 9 March 2017
Research article
MicroRNAs (miRNAs) are a group of short non-coding RNAs involved in the inhibition of protein translation or in mRNA degradation. Although the regulatory roles of miRNAs in various biological processes have be...
BMC Molecular Biology 2017 18:5
Published on: 16 February 2017
Research article
Pheromone binding proteins (PBPs) of male Lepidoptera function in chemical communication, mate attraction and recognition. Directional selection was previously predicted between PBP3 orthologs of Ostrinia furnaca...
BMC Molecular Biology 2017 18:4
Published on: 7 February 2017
Research article
The mammalian sperm-associated antigen 16 gene (Spag16) uses alternative promoters to produce two major transcript isoforms (Spag16L and Spag16S) and encode proteins that are involved in the cilia/flagella format...
BMC Molecular Biology 2017 18:2
Published on: 31 January 2017
Research article
Cells respond to numerous internal and external stresses, such as heat, cold, oxidative stress, DNA damage, and osmotic pressure changes. In most cases, the primary response to stress is transcriptional induct...
BMC Molecular Biology 2016 17:20
Published on: 30 August 2016
Research article
Nonsense-mediated mRNA decay (NMD) is a RNA quality surveillance system for eukaryotes. It prevents cells from generating deleterious truncated proteins by degrading abnormal mRNAs that harbor premature termin...
BMC Molecular Biology 2016 17:17
Published on: 29 July 2016
Research article
Stearoyl-CoA desaturase 1 (SCD1) desaturates long chain fatty acids and is therefore a key enzyme in fat catabolism. Its synthesis is downregulated in liver during illnesses caused by high levels of circulatin...
BMC Molecular Biology 2016 17:16
Published on: 20 July 2016
Research Article
In contrast to rat and mouse databases, the NCBI gene database lists the human dual-endothelin1/VEGFsp receptor (DEspR, formerly Dear) as a unitary transcribed pseudogene due to a stop [TGA]-codon at codon#14 in ...
BMC Molecular Biology 2016 17:15
Published on: 14 June 2016
Research article
c-Myc has been proposed as a putative target gene of signal transducer and activator of transcription 5 (STAT5). No functional STAT5 binding site has been identified so far within the
BMC Molecular Biology 2016 17:10
Published on: 14 April 2016
Methodology article
The majority of protein isoforms arise from alternative splicing of the encoding primary RNA transcripts. To understand the significance of single splicing events, reliable techniques are needed to determine t...
BMC Molecular Biology 2016 17:8
Published on: 15 March 2016
