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DNA replication and genome stability

Section edited by Stuart MacNeill

This section will consider submissions focusing on molecular mechanisms of DNA replication, DNA repair, recombination and transposition in bacteria, archaea, eukaryotes and viruses.

  1. Content type: Research article

    GTPase-activating proteins (GAPs) with a TBC (Tre-2/Bub2/Cdc16) domain architecture serve as negative regulators of Rab GTPases. The related crystal structure has been studied and reported by other members of ...

    Authors: Yangyang Jin, Guodong Lin, Yanna Chen, Yinghua Ge, Ruofeng Liang, Jia Wu, Jianqing Chen, Dan Wang, Hengbo Shi, Hui Fei and Zhengbing Lv

    Citation: BMC Molecular Biology 2019 20:5

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  2. Content type: Research article

    DNA replication requires contributions from various proteins, such as DNA helicases; in mitochondria Twinkle is important for maintaining and replicating mitochondrial DNA. Twinkle helicases are predicted to a...

    Authors: Ashley Harman and Christian Barth

    Citation: BMC Molecular Biology 2018 19:12

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  3. Content type: Methodology article

    Clustered regularly interspaced short palindromic repeat (CRISPR) RNA-guided adaptive immune systems are found in prokaryotes to defend cells from foreign DNA. CRISPR Cas9 systems have been modified and employ...

    Authors: Neftali Vazquez, Lilia Sanchez, Rebecca Marks, Eduardo Martinez, Victor Fanniel, Alma Lopez, Andrea Salinas, Itzel Flores, Jesse Hirschmann, Robert Gilkerson, Erin Schuenzel, Robert Dearth, Reginald Halaby, Wendy Innis-Whitehouse and Megan Keniry

    Citation: BMC Molecular Biology 2018 19:3

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    The Correction to this article has been published in BMC Molecular Biology 2019 20:20

  4. Content type: Research article

    We have recently reported that cell-free DNA (cfDNA) fragments derived from dying cells that circulate in blood are biologically active molecules and can readily enter into healthy cells to activate DNA damage...

    Authors: Gorantla Venkata Raghuram, Deepika Gupta, Siddharth Subramaniam, Ashwini Gaikwad, Naveen Kumar Khare, Malcolm Nobre, Naveen Kumar Nair and Indraneel Mittra

    Citation: BMC Molecular Biology 2017 18:21

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  5. Content type: Research article

    Maintenance of genome stability is critical in human cells. Mutations in or loss of genome stability pathways can lead to a number of pathologies including cancer. hSSB1 is a critical DNA repair protein functi...

    Authors: Laura V. Croft, Nicholas W. Ashton, Nicolas Paquet, Emma Bolderson, Kenneth J. O’Byrne and Derek J. Richard

    Citation: BMC Molecular Biology 2017 18:13

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  6. Content type: Research article

    Immunoglobulins (Igs) are fundamental components of the adaptive immune system of vertebrates, with the IgT/IgZ isotype specific of Teleosts. In this paper we describe the identification of an IgT heavy chain ...

    Authors: Francesco Buonocore, Valentina Stocchi, Noelia Nunez-Ortiz, Elisa Randelli, Marco Gerdol, Alberto Pallavicini, Angelo Facchiano, Chiara Bernini, Laura Guerra, Giuseppe Scapigliati and Simona Picchietti

    Citation: BMC Molecular Biology 2017 18:8

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  7. Content type: Methodology article

    It has been pointed out that environmental factors or chemicals can cause diseases that are developmental in origin. To detect abnormal epigenetic alterations in DNA methylation, convenient and cost-effective ...

    Authors: Toshiki Aiba, Toshiyuki Saito, Akiko Hayashi, Shinji Sato, Harunobu Yunokawa, Toru Maruyama, Wataru Fujibuchi, Hisaka Kurita, Chiharu Tohyama and Seiichiroh Ohsako

    Citation: BMC Molecular Biology 2017 18:7

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  8. Content type: Research article

    Single-stranded DNA-binding proteins are essential cellular components required for the protection, metabolism and processing of single-stranded DNA. Human single-stranded DNA-binding protein 1 (hSSB1) is one ...

    Authors: Nicholas W. Ashton, Dorothy Loo, Nicolas Paquet, Kenneth J. O’Byrne and Derek J. Richard

    Citation: BMC Molecular Biology 2016 17:24

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  9. Content type: Review

    Nucleophosmin (NPM1) is a critical cellular protein that has been implicated in a number of pathways including mRNA transport, chromatin remodeling, apoptosis and genome stability. NPM1 function is a critical ...

    Authors: Joseph K. Box, Nicolas Paquet, Mark N. Adams, Didier Boucher, Emma Bolderson, Kenneth J. O’Byrne and Derek J. Richard

    Citation: BMC Molecular Biology 2016 17:19

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  10. Content type: Research article

    Studies of DNA damage response are critical for the comprehensive understanding of age-related changes in cells, tissues and organisms. Syrian hamster cells halt proliferation and become presenescent after sev...

    Authors: Ljudmila Solovjeva, Denis Firsanov, Anastasia Vasilishina, Vadim Chagin, Nadezhda Pleskach, Andrey Kropotov and Maria Svetlova

    Citation: BMC Molecular Biology 2015 16:18

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  11. Content type: Research article

    Reverse gyrases are DNA topoisomerases characterized by their unique DNA positive-supercoiling activity. Sulfolobus solfataricus, like most Crenarchaeota, contains two genes each encoding a reverse gyrase. We sho...

    Authors: Mohea Couturier, Anna H Bizard, Florence Garnier and Marc Nadal

    Citation: BMC Molecular Biology 2014 15:18

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  12. Content type: Research article

    Human MutY glycosylase homolog (hMYH), a component of the base excision repair pathway, is responsible for the generation of apurinic/apyrimidinic sites. Rad9-Rad1-Hus1 (9-1-1) is a heterotrimeric protein comp...

    Authors: Lia Agustina, Soo-Hyun Hahm, Se Hee Han, An Hue Vy Tran, Ji Hyung Chung, Jong-Hwa Park, Jin Woo Park and Ye Sun Han

    Citation: BMC Molecular Biology 2014 15:17

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  13. Content type: Methodology article

    The plant pathogenic and saprophytic fungus Fusarium avenaceum causes considerable in-field and post-field losses worldwide due to its infections of a wide range of different crops. Despite its significant impact...

    Authors: Lisette Quaade Sørensen, Erik Lysøe, Jesper Erup Larsen, Paiman Khorsand-Jamal, Kristian Fog Nielsen and Rasmus John Normand Frandsen

    Citation: BMC Molecular Biology 2014 15:15

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  14. Content type: Research article

    Homologous recombination mediated gene targeting is still too inefficient to be applied extensively in genomics and gene therapy. Although sequence-specific nucleases could greatly stimulate gene targeting eff...

    Authors: Alvaro Galli and Tiziana Cervelli

    Citation: BMC Molecular Biology 2014 15:5

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  15. Content type: Review

    The terminal step in the ubiquitin modification system relies on an E3 ubiquitin ligase to facilitate transfer of ubiquitin to a protein substrate. The substrate recognition and ubiquitin transfer activities o...

    Authors: Tadashi Nakagawa, Koushik Mondal and Patrick C Swanson

    Citation: BMC Molecular Biology 2013 14:22

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  16. Content type: Research article

    Phage PhiC31 integrase integrates attB-containing plasmid into pseudo attP site in eukaryotic genomes in a unidirectional site-specific manner and maintains robust transgene expression. Few studies, however, e...

    Authors: Yanzhen Bi, Ximei Liu, Long Zhang, Changwei Shao, Zhuo Ma, Zaidong Hua, Liping Zhang, Li Li, Wenjun Hua, Hongwei Xiao, Qingxin Wei and Xinmin Zheng

    Citation: BMC Molecular Biology 2013 14:20

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  17. Content type: Research article

    In continuing our research into the new family of bifunctional restriction endonucleases (REases), we describe the cloning of the tsoIRM gene. Currently, the family includes six thermostable enzymes: TaqII, Tth11...

    Authors: Piotr M Skowron, Jolanta Vitkute, Danute Ramanauskaite, Goda Mitkaite, Joanna Jezewska-Frackowiak, Joanna Zebrowska, Agnieszka Zylicz-Stachula and Arvydas Lubys

    Citation: BMC Molecular Biology 2013 14:17

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  18. Content type: Review

    The double-stranded conformation of cellular DNA is a central aspect of DNA stabilisation and protection. The helix preserves the genetic code against chemical and enzymatic degradation, metabolic activation, ...

    Authors: Nicholas W Ashton, Emma Bolderson, Liza Cubeddu, Kenneth J O’Byrne and Derek J Richard

    Citation: BMC Molecular Biology 2013 14:9

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  19. Content type: Research article

    In Drosophila embryos, checkpoints maintain genome stability by delaying cell cycle progression that allows time for damage repair or to complete DNA synthesis. Drosophila MOF, a member of MYST histone acetyl tra...

    Authors: Sreerangam NCVL Pushpavalli, Arpita Sarkar, M Janaki Ramaiah, Debabani Roy Chowdhury, Utpal Bhadra and Manika Pal-Bhadra

    Citation: BMC Molecular Biology 2013 14:1

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  20. Content type: Research article

    Autonomously Replicating Sequences (ARS) in S. cerevisiae serve as origins of DNA replication or as components of cis-acting silencers, which impose positional repression at the mating type loci and at the telome...

    Authors: Patricia Chisamore-Robert, Samantha Peeters, Kristina Shostak and Krassimir Yankulov

    Citation: BMC Molecular Biology 2012 13:34

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  21. Content type: Methodology article

    Recombinatorial cloning using the GatewayTM technology has been the method of choice for high-throughput omics projects, resulting in the availability of entire ORFeomes in GatewayTM compatible vectors. The Multi...

    Authors: Astrid Nagels Durand, Tessa Moses, Rebecca De Clercq, Alain Goossens and Laurens Pauwels

    Citation: BMC Molecular Biology 2012 13:30

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