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DNA structure, chromatin and nuclear organization

This section will consider submissions which focus on DNA structure and topology, chromatin and chromatin remodeling, epigenetics and nuclear organization.

  1. Content type: Research article

    Receptor-interacting serine-threonine kinase 3 (RIPK3)-mediated necroptosis has been implicated in the progression of myocardial infarction (MI), but the underlying mechanisms, particularly whether microRNAs (...

    Authors: Dong-Ying Zhang, Bing-Jian Wang, Min Ma, Kun Yu, Qing Zhang and Xi-Wen Zhang

    Citation: BMC Molecular Biology 2019 20:17

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    The Correction to this article has been published in BMC Molecular Biology 2019 20:18

  2. Content type: Research article

    Lectins have come a long way from being identified as proteins that agglutinate cells to promising therapeutic agents in modern medicine. Through their specific binding property, they have proven to be anti-ca...

    Authors: Kshema Thakur, Tarnjeet Kaur, Manpreet Kaur, Rachna Hora and Jatinder Singh

    Citation: BMC Molecular Biology 2019 20:15

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  3. Content type: Research article

    Small nucleolar RNAs (snoRNAs) function in guiding 2′-O-methylation and pseudouridylation of ribosomal RNAs (rRNAs) and small nuclear RNAs (snRNAs). In recent years, more and more snoRNAs have been found to play ...

    Authors: Bo Wu, Lei Huang, Wujie Qiu, Xiao Liu, Yawen Shen, Yiping Lu, Zonglin Yang, Xinmei Li, Bin Cui, Shidong Xu, Huili Qiao, Reng Qiu, Lunguang Yao, Yunchao Kan and Dandan Li

    Citation: BMC Molecular Biology 2019 20:12

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  4. Content type: Research article

    Oxidative stress is known to be involved in most of the aetiological factors of nasopharyngeal carcinoma (NPC). Cells that are under oxidative stress may undergo apoptosis. We have previously demonstrated that...

    Authors: Sang-Nee Tan, Sai-Peng Sim and Alan S. B. Khoo

    Citation: BMC Molecular Biology 2018 19:15

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  5. Content type: Research article

    Farnesyl pyrophosphate synthase (FPS) belongs to the short-chain prenyltransferase family, and it performs a conserved and essential role in the terpenoid biosynthesis pathway. However, its classification, evo...

    Authors: Jieying Qian, Yong Liu, Naixia Chao, Chengtong Ma, Qicong Chen, Jian Sun and Yaosheng Wu

    Citation: BMC Molecular Biology 2017 18:3

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  6. Content type: Research article

    DNA methylation is a major epigenetic modification, playing a crucial role in the development and differentiation of higher organisms. DNA methylation is also known to regulate transcription by gene repression...

    Authors: Puja Sinha, Kiran Singh and Manisha Sachan

    Citation: BMC Molecular Biology 2017 18:1

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  7. Content type: Methodology article

    Chromosome conformation capture (3C) is a powerful and widely used technique for detecting the physical interactions between chromatin regions in vivo. The principle of 3C is to convert physical chromatin inte...

    Authors: Meijun Du and Liang Wang

    Citation: BMC Molecular Biology 2016 17:23

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  8. Content type: Research article

    Ataxia telangiectasia mutated (ATM) and TRRAP proteins belong to the phosphatidylinositol 3-kinase-related kinase family and are involved in DNA damage repair and chromatin remodeling. ATM is a checkpoint kina...

    Authors: Rebecca J. Smith, Matthew S. Savoian, Lauren E. Weber and Jeong Hyeon Park

    Citation: BMC Molecular Biology 2016 17:22

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  9. Content type: Research article

    The breast and ovarian cancer susceptibility gene BRCA1 encodes a multifunctional tumor suppressor protein BRCA1, which is involved in regulating cellular processes such as cell cycle, transcription, DNA repair, ...

    Authors: Václav Brázda, Lucia Hároníková, Jack C. C. Liao, Helena Fridrichová and Eva B. Jagelská

    Citation: BMC Molecular Biology 2016 17:14

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  10. Content type: Methodology article

    Targeted genomic editing using the CRISPR/Cas9 methodology has opened exciting new avenues in probing gene function in virtually any model system, including cultured mammalian cells. Depending on the desired m...

    Authors: Jason A. Estep, Erin L. Sternburg, Gissell A. Sanchez and Fedor V. Karginov

    Citation: BMC Molecular Biology 2016 17:9

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  11. Content type: Research article

    Premature aging syndromes recapitulate many aspects of natural aging and provide an insight into this phenomenon at a molecular and cellular level. The progeria syndromes appear to cause rapid aging through di...

    Authors: Nicolas Paquet, Joseph K Box, Nicholas W Ashton, Amila Suraweera, Laura V Croft, Aaron J Urquhart, Emma Bolderson, Shu-Dong Zhang, Kenneth J O’Byrne and Derek J Richard

    Citation: BMC Molecular Biology 2014 15:27

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  12. Content type: Methodology article

    Comprehensive understanding of mechanisms of genome functions requires identification of molecules interacting with genomic regions of interest in vivo. We previously developed the insertional chromatin immunopre...

    Authors: Toshitsugu Fujita and Hodaka Fujii

    Citation: BMC Molecular Biology 2014 15:26

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  13. Content type: Research article

    The past decade has seen the emergence of several molecular tools that render possible modification of cellular functions through accurate and easy addition, removal, or exchange of genomic DNA sequences. Amon...

    Authors: Alexandre Juillerat, Marine Beurdeley, Julien Valton, Séverine Thomas, Gwendoline Dubois, Mikhail Zaslavskiy, Jérome Mikolajczak, Fabian Bietz, George H Silva, Aymeric Duclert, Fayza Daboussi and Philippe Duchateau

    Citation: BMC Molecular Biology 2014 15:13

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