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  1. Research article

    Selective measurement of α smooth muscle actin: why β-actin can not be used as a housekeeping gene when tissue fibrosis occurs

    Prevalence of fibroproliferative diseases, including chronic kidney disease is rapidly increasing and has become a major public health problem worldwide. Fibroproliferative diseases are characterized by increa...

    Apor Veres-Székely, Domonkos Pap, Erna Sziksz, Eszter Jávorszky, Réka Rokonay, Rita Lippai, Kálmán Tory, Andrea Fekete, Tivadar Tulassay, Attila J. Szabó and Ádám Vannay

    BMC Molecular Biology 2017 18:12

    Published on: 27 April 2017

  2. Research article

    Identification of suitable reference genes for real-time quantitative PCR analysis of hydrogen peroxide-treated human umbilical vein endothelial cells

    Oxidative stress can induce cell injury in vascular endothelial cells, which is the initial event in the development of atherosclerosis. Although quantitative real-time polymerase chain reaction (qRT-PCR) has ...

    Tianyi Li, Hongying Diao, Lei Zhao, Yue Xing, Jichang Zhang, Ning Liu, Youyou Yan, Xin Tian, Wei Sun and Bin Liu

    BMC Molecular Biology 2017 18:10

    Published on: 5 April 2017

  3. Research article

    RUNX1 induces DNA replication independent active DNA demethylation at SPI1 regulatory regions

    SPI1 is an essential transcription factor (TF) for the hematopoietic lineage, in which its expression is tightly controlled through a −17-kb upstream regulatory region and a promoter region. Both regulatory re...

    Shubham Goyal, Takahiro Suzuki, Jing-Ru Li, Shiori Maeda, Mami Kishima, Hajime Nishimura, Yuri Shimizu and Harukazu Suzuki

    BMC Molecular Biology 2017 18:9

    Published on: 4 April 2017

    The Erratum to this article has been published in BMC Molecular Biology 2017 18:11

  4. Research article

    Immunoglobulin T from sea bass (Dicentrarchus labrax L.): molecular characterization, tissue localization and expression after nodavirus infection

    Immunoglobulins (Igs) are fundamental components of the adaptive immune system of vertebrates, with the IgT/IgZ isotype specific of Teleosts. In this paper we describe the identification of an IgT heavy chain ...

    Francesco Buonocore, Valentina Stocchi, Noelia Nunez-Ortiz, Elisa Randelli, Marco Gerdol, Alberto Pallavicini, Angelo Facchiano, Chiara Bernini, Laura Guerra, Giuseppe Scapigliati and Simona Picchietti

    BMC Molecular Biology 2017 18:8

    Published on: 15 March 2017

  5. Methodology article

    Methylated site display (MSD)-AFLP, a sensitive and affordable method for analysis of CpG methylation profiles

    It has been pointed out that environmental factors or chemicals can cause diseases that are developmental in origin. To detect abnormal epigenetic alterations in DNA methylation, convenient and cost-effective ...

    Toshiki Aiba, Toshiyuki Saito, Akiko Hayashi, Shinji Sato, Harunobu Yunokawa, Toru Maruyama, Wataru Fujibuchi, Hisaka Kurita, Chiharu Tohyama and Seiichiroh Ohsako

    BMC Molecular Biology 2017 18:7

    Published on: 9 March 2017

  6. Research article

    Properties of STAT1 and IRF1 enhancers and the influence of SNPs

    STAT1 and IRF1 collaborate to induce interferon-γ (IFNγ) stimulated genes (ISGs), but the extent to which they act alone or together is unclear. The effect of single nucleotide polymorphisms (SNPs) on in vivo ...

    Mohamed Abou El Hassan, Katherine Huang, Manoja B. K. Eswara, Zhaodong Xu, Tao Yu, Arthur Aubry, Zuyao Ni, Izzy Livne-bar, Monika Sangwan, Mohamad Ahmad and Rod Bremner

    BMC Molecular Biology 2017 18:6

    Published on: 9 March 2017

  7. Research article

    Identification of microRNAs and their response to the stress of plant allelochemicals in Aphis gossypii (Hemiptera: Aphididae)

    MicroRNAs (miRNAs) are a group of short non-coding RNAs involved in the inhibition of protein translation or in mRNA degradation. Although the regulatory roles of miRNAs in various biological processes have be...

    Kang-Sheng Ma, Fen Li, Ying Liu, Ping-Zhuo Liang, Xue-Wei Chen and Xi-Wu Gao

    BMC Molecular Biology 2017 18:5

    Published on: 16 February 2017

  8. Research article

    Binding affinity of five PBPs to Ostrinia sex pheromones

    Pheromone binding proteins (PBPs) of male Lepidoptera function in chemical communication, mate attraction and recognition. Directional selection was previously predicted between PBP3 orthologs of Ostrinia furnaca...

    Tiantao Zhang, Yaqi Sun, Kevin W. Wanner, Brad S. Coates, Kanglai He and Zhenying Wang

    BMC Molecular Biology 2017 18:4

    Published on: 7 February 2017

  9. Research article

    Transcriptional regulation of human sperm-associated antigen 16 gene by S-SOX5

    The mammalian sperm-associated antigen 16 gene (Spag16) uses alternative promoters to produce two major transcript isoforms (Spag16L and Spag16S) and encode proteins that are involved in the cilia/flagella format...

    Ling Zhang, Yunhao Liu, Wei Li, Qiaoling Zhang, Yanwei Li, Junpin Liu, Jie Min, Chaofan Shuang, Shizheng Song and Zhibing Zhang

    BMC Molecular Biology 2017 18:2

    Published on: 31 January 2017

  10. Research article

    Novel insight into the composition of human single-stranded DNA-binding protein 1 (hSSB1)-containing protein complexes

    Single-stranded DNA-binding proteins are essential cellular components required for the protection, metabolism and processing of single-stranded DNA. Human single-stranded DNA-binding protein 1 (hSSB1) is one ...

    Nicholas W. Ashton, Dorothy Loo, Nicolas Paquet, Kenneth J. O’Byrne and Derek J. Richard

    BMC Molecular Biology 2016 17:24

    Published on: 9 December 2016

  11. Methodology article

    3C-digital PCR for quantification of chromatin interactions

    Chromosome conformation capture (3C) is a powerful and widely used technique for detecting the physical interactions between chromatin regions in vivo. The principle of 3C is to convert physical chromatin inte...

    Meijun Du and Liang Wang

    BMC Molecular Biology 2016 17:23

    Published on: 6 December 2016

  12. Research article

    Distinct recruitment of human eIF4E isoforms to processing bodies and stress granules

    Eukaryotic translation initiation factor 4E (eIF4E) plays a pivotal role in the control of cap-dependent translation initiation, modulates the fate of specific mRNAs, occurs in processing bodies (PBs) and is r...

    Klara Frydryskova, Tomas Masek, Katerina Borcin, Silvia Mrvova, Veronica Venturi and Martin Pospisek

    BMC Molecular Biology 2016 17:21

    Published on: 30 August 2016

  13. Research article

    RNA polymerase II depletion promotes transcription of alternative mRNA species

    Cells respond to numerous internal and external stresses, such as heat, cold, oxidative stress, DNA damage, and osmotic pressure changes. In most cases, the primary response to stress is transcriptional induct...

    Lijian Yu, Mayuri Rege, Craig L. Peterson and Michael R. Volkert

    BMC Molecular Biology 2016 17:20

    Published on: 30 August 2016

  14. Review

    Nucleophosmin: from structure and function to disease development

    Nucleophosmin (NPM1) is a critical cellular protein that has been implicated in a number of pathways including mRNA transport, chromatin remodeling, apoptosis and genome stability. NPM1 function is a critical ...

    Joseph K. Box, Nicolas Paquet, Mark N. Adams, Didier Boucher, Emma Bolderson, Kenneth J. O’Byrne and Derek J. Richard

    BMC Molecular Biology 2016 17:19

    Published on: 24 August 2016

  15. Research article

    Stearoyl-CoA desaturase 1 expression is downregulated in liver and udder during E. coli mastitis through enhanced expression of repressive C/EBP factors and reduced expression of the inducer SREBP1A

    Stearoyl-CoA desaturase 1 (SCD1) desaturates long chain fatty acids and is therefore a key enzyme in fat catabolism. Its synthesis is downregulated in liver during illnesses caused by high levels of circulatin...

    Tianle Xu, Xiangzhen Shen and Hans-Martin Seyfert

    BMC Molecular Biology 2016 17:16

    Published on: 20 July 2016

  16. Research Article

    Confirmation of translatability and functionality certifies the dual endothelin1/VEGFsp receptor (DEspR) protein

    In contrast to rat and mouse databases, the NCBI gene database lists the human dual-endothelin1/VEGFsp receptor (DEspR, formerly Dear) as a unitary transcribed pseudogene due to a stop [TGA]-codon at codon#14 in ...

    Victoria L. M. Herrera, Martin Steffen, Ann Marie Moran, Glaiza A. Tan, Khristine A. Pasion, Keith Rivera, Darryl J. Pappin and Nelson Ruiz-Opazo

    BMC Molecular Biology 2016 17:15

    Published on: 14 June 2016

  17. Research article

    Strong preference of BRCA1 protein to topologically constrained non-B DNA structures

    The breast and ovarian cancer susceptibility gene BRCA1 encodes a multifunctional tumor suppressor protein BRCA1, which is involved in regulating cellular processes such as cell cycle, transcription, DNA repair, ...

    Václav Brázda, Lucia Hároníková, Jack C. C. Liao, Helena Fridrichová and Eva B. Jagelská

    BMC Molecular Biology 2016 17:14

    Published on: 8 June 2016

  18. Research article

    A potential role for protein palmitoylation and zDHHC16 in DNA damage response

    Cells respond to DNA damage by activating the phosphatidylinositol-3 kinase-related kinases, p53 and other pathways to promote cell cycle arrest, apoptosis, and/or DNA repair. Here we report that protein palmi...

    Na Cao, Jia-Kai Li, Yu-Qing Rao, Huijuan Liu, Ji Wu, Baojie Li, Peiquan Zhao, Li Zeng and Jing Li

    BMC Molecular Biology 2016 17:12

    Published on: 10 May 2016

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