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Research article
Mitogenome diversity is staggering among early branching animals with respect to size, gene density, content and order, and number of tRNA genes, especially in cnidarians. This last point is of special interes...
BMC Molecular Biology 2017 18:16
Published on: 17 June 2017
Research article
The denervated hippocampus provides a proper microenvironment for the survival and neuronal differentiation of neural progenitors. While thousands of lncRNAs were identified, only a few lncRNAs that regulate n...
BMC Molecular Biology 2017 18:15
Published on: 6 June 2017
Research article
Along with sodium/calcium (Ca2+) exchangers, plasma membrane Ca2+ ATPases (ATP2Bs) are main regulators of intracellular Ca2+ levels. There are four ATP2B paralogs encoded by four different genes. Atp2b2 encodes t...
BMC Molecular Biology 2017 18:14
Published on: 22 May 2017
Research article
Maintenance of genome stability is critical in human cells. Mutations in or loss of genome stability pathways can lead to a number of pathologies including cancer. hSSB1 is a critical DNA repair protein functi...
BMC Molecular Biology 2017 18:13
Published on: 15 May 2017
Research article
Prevalence of fibroproliferative diseases, including chronic kidney disease is rapidly increasing and has become a major public health problem worldwide. Fibroproliferative diseases are characterized by increa...
BMC Molecular Biology 2017 18:12
Published on: 27 April 2017
Erratum
BMC Molecular Biology 2017 18:11
Published on: 21 April 2017
The original article was published in BMC Molecular Biology 2017 18:9
Research article
Oxidative stress can induce cell injury in vascular endothelial cells, which is the initial event in the development of atherosclerosis. Although quantitative real-time polymerase chain reaction (qRT-PCR) has ...
BMC Molecular Biology 2017 18:10
Published on: 5 April 2017
Research article
SPI1 is an essential transcription factor (TF) for the hematopoietic lineage, in which its expression is tightly controlled through a −17-kb upstream regulatory region and a promoter region. Both regulatory re...
BMC Molecular Biology 2017 18:9
Published on: 4 April 2017
The Erratum to this article has been published in BMC Molecular Biology 2017 18:11
Research article
Immunoglobulins (Igs) are fundamental components of the adaptive immune system of vertebrates, with the IgT/IgZ isotype specific of Teleosts. In this paper we describe the identification of an IgT heavy chain ...
BMC Molecular Biology 2017 18:8
Published on: 15 March 2017
Methodology article
It has been pointed out that environmental factors or chemicals can cause diseases that are developmental in origin. To detect abnormal epigenetic alterations in DNA methylation, convenient and cost-effective ...
BMC Molecular Biology 2017 18:7
Published on: 9 March 2017
Research article
STAT1 and IRF1 collaborate to induce interferon-γ (IFNγ) stimulated genes (ISGs), but the extent to which they act alone or together is unclear. The effect of single nucleotide polymorphisms (SNPs) on in vivo ...
BMC Molecular Biology 2017 18:6
Published on: 9 March 2017
Research article
MicroRNAs (miRNAs) are a group of short non-coding RNAs involved in the inhibition of protein translation or in mRNA degradation. Although the regulatory roles of miRNAs in various biological processes have be...
BMC Molecular Biology 2017 18:5
Published on: 16 February 2017
Research article
Pheromone binding proteins (PBPs) of male Lepidoptera function in chemical communication, mate attraction and recognition. Directional selection was previously predicted between PBP3 orthologs of Ostrinia furnaca...
BMC Molecular Biology 2017 18:4
Published on: 7 February 2017
Research article
Farnesyl pyrophosphate synthase (FPS) belongs to the short-chain prenyltransferase family, and it performs a conserved and essential role in the terpenoid biosynthesis pathway. However, its classification, evo...
BMC Molecular Biology 2017 18:3
Published on: 4 February 2017
Research article
The mammalian sperm-associated antigen 16 gene (Spag16) uses alternative promoters to produce two major transcript isoforms (Spag16L and Spag16S) and encode proteins that are involved in the cilia/flagella format...
BMC Molecular Biology 2017 18:2
Published on: 31 January 2017
Research article
DNA methylation is a major epigenetic modification, playing a crucial role in the development and differentiation of higher organisms. DNA methylation is also known to regulate transcription by gene repression...
BMC Molecular Biology 2017 18:1
Published on: 11 January 2017
Research article
Single-stranded DNA-binding proteins are essential cellular components required for the protection, metabolism and processing of single-stranded DNA. Human single-stranded DNA-binding protein 1 (hSSB1) is one ...
BMC Molecular Biology 2016 17:24
Published on: 9 December 2016
Methodology article
Chromosome conformation capture (3C) is a powerful and widely used technique for detecting the physical interactions between chromatin regions in vivo. The principle of 3C is to convert physical chromatin inte...
BMC Molecular Biology 2016 17:23
Published on: 6 December 2016
Research article
Ataxia telangiectasia mutated (ATM) and TRRAP proteins belong to the phosphatidylinositol 3-kinase-related kinase family and are involved in DNA damage repair and chromatin remodeling. ATM is a checkpoint kina...
BMC Molecular Biology 2016 17:22
Published on: 4 November 2016
Research article
Eukaryotic translation initiation factor 4E (eIF4E) plays a pivotal role in the control of cap-dependent translation initiation, modulates the fate of specific mRNAs, occurs in processing bodies (PBs) and is r...
BMC Molecular Biology 2016 17:21
Published on: 30 August 2016
Research article
Cells respond to numerous internal and external stresses, such as heat, cold, oxidative stress, DNA damage, and osmotic pressure changes. In most cases, the primary response to stress is transcriptional induct...
BMC Molecular Biology 2016 17:20
Published on: 30 August 2016
Review
Nucleophosmin (NPM1) is a critical cellular protein that has been implicated in a number of pathways including mRNA transport, chromatin remodeling, apoptosis and genome stability. NPM1 function is a critical ...
BMC Molecular Biology 2016 17:19
Published on: 24 August 2016
Research article
Serine–arginine rich splicing factor 2 (SRSF2) is a protein known for its role in RNA splicing and genome stability. It has been recently discovered that SRSF2, along with other splicing regulators, is frequen...
BMC Molecular Biology 2016 17:18
Published on: 23 August 2016
Research article
Nonsense-mediated mRNA decay (NMD) is a RNA quality surveillance system for eukaryotes. It prevents cells from generating deleterious truncated proteins by degrading abnormal mRNAs that harbor premature termin...
BMC Molecular Biology 2016 17:17
Published on: 29 July 2016
Research article
Stearoyl-CoA desaturase 1 (SCD1) desaturates long chain fatty acids and is therefore a key enzyme in fat catabolism. Its synthesis is downregulated in liver during illnesses caused by high levels of circulatin...
BMC Molecular Biology 2016 17:16
Published on: 20 July 2016
