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  1. Research article

    Physical shearing imparts biological activity to DNA and ability to transmit itself horizontally across species and kingdom boundaries

    We have recently reported that cell-free DNA (cfDNA) fragments derived from dying cells that circulate in blood are biologically active molecules and can readily enter into healthy cells to activate DNA damage...

    Gorantla Venkata Raghuram, Deepika Gupta, Siddharth Subramaniam, Ashwini Gaikwad, Naveen Kumar Khare, Malcolm Nobre, Naveen Kumar Nair and Indraneel Mittra

    BMC Molecular Biology 2017 18:21

    Published on: 9 August 2017

  2. Research article

    Splicing arrays reveal novel RBM10 targets, including SMN2 pre-mRNA

    RBM10 is an RNA binding protein involved in message stabilization and alternative splicing regulation. The objective of the research described herein was to identify novel targets of RBM10-regulated splicing. ...

    Leslie C. Sutherland, Philippe Thibault, Mathieu Durand, Elvy Lapointe, Jose M. Knee, Ariane Beauvais, Irina Kalatskaya, Sarah C. Hunt, Julie J. Loiselle, Justin G. Roy, Sarah J. Tessier, Gustavo Ybazeta, Lincoln Stein, Rashmi Kothary, Roscoe Klinck and Benoit Chabot

    BMC Molecular Biology 2017 18:19

    Published on: 20 July 2017

  3. Research article

    Growth arrest specific gene 2 in tilapia (Oreochromis niloticus): molecular characterization and functional analysis under low-temperature stress

    Growth arrest specific 2 (gas2) gene is a component of the microfilament system that plays a major role in the cell cycle, regulation of microfilaments, and cell morphology during apoptotic processes. However, li...

    ChangGeng Yang, Fan Wu, Xing Lu, Ming Jiang, Wei Liu, Lijuan Yu, Juan Tian and Hua Wen

    BMC Molecular Biology 2017 18:18

    Published on: 17 July 2017

  4. Research article

    Identification of G-quadruplex structures that possess transcriptional regulating functions in the Dele and Cdc6 CpG islands

    G-quadruplex is a DNA secondary structure that has been shown to play an important role in biological systems. In a previous study, we identified 1998 G-quadruplex-forming sequences using a mouse CpG islands D...

    Daniyah H. Bay, Annika Busch, Fred Lisdat, Keisuke Iida, Kazunori Ikebukuro, Kazuo Nagasawa, Isao Karube and Wataru Yoshida

    BMC Molecular Biology 2017 18:17

    Published on: 27 June 2017

  5. Research article

    Mitochondrial RNA processing in absence of tRNA punctuations in octocorals

    Mitogenome diversity is staggering among early branching animals with respect to size, gene density, content and order, and number of tRNA genes, especially in cnidarians. This last point is of special interes...

    Gaurav G. Shimpi, Sergio Vargas, Angelo Poliseno and Gert Wörheide

    BMC Molecular Biology 2017 18:16

    Published on: 17 June 2017

  6. Research article

    Microarray expression profiling in the denervated hippocampus identifies long noncoding RNAs functionally involved in neurogenesis

    The denervated hippocampus provides a proper microenvironment for the survival and neuronal differentiation of neural progenitors. While thousands of lncRNAs were identified, only a few lncRNAs that regulate n...

    Bingying Deng, Xiang Cheng, Haoming Li, Jianbing Qin, Meiling Tian and Guohua Jin

    BMC Molecular Biology 2017 18:15

    Published on: 6 June 2017

  7. Research article

    Early growth response protein 1 regulates promoter activity of α-plasma membrane calcium ATPase 2, a major calcium pump in the brain and auditory system

    Along with sodium/calcium (Ca2+) exchangers, plasma membrane Ca2+ ATPases (ATP2Bs) are main regulators of intracellular Ca2+ levels. There are four ATP2B paralogs encoded by four different genes. Atp2b2 encodes t...

    Rebecca R. Minich, Jin Li and Bruce L. Tempel

    BMC Molecular Biology 2017 18:14

    Published on: 22 May 2017

  8. Research article

    hSSB1 associates with and promotes stability of the BLM helicase

    Maintenance of genome stability is critical in human cells. Mutations in or loss of genome stability pathways can lead to a number of pathologies including cancer. hSSB1 is a critical DNA repair protein functi...

    Laura V. Croft, Nicholas W. Ashton, Nicolas Paquet, Emma Bolderson, Kenneth J. O’Byrne and Derek J. Richard

    BMC Molecular Biology 2017 18:13

    Published on: 15 May 2017

  9. Research article

    Selective measurement of α smooth muscle actin: why β-actin can not be used as a housekeeping gene when tissue fibrosis occurs

    Prevalence of fibroproliferative diseases, including chronic kidney disease is rapidly increasing and has become a major public health problem worldwide. Fibroproliferative diseases are characterized by increa...

    Apor Veres-Székely, Domonkos Pap, Erna Sziksz, Eszter Jávorszky, Réka Rokonay, Rita Lippai, Kálmán Tory, Andrea Fekete, Tivadar Tulassay, Attila J. Szabó and Ádám Vannay

    BMC Molecular Biology 2017 18:12

    Published on: 27 April 2017

  10. Research article

    Identification of suitable reference genes for real-time quantitative PCR analysis of hydrogen peroxide-treated human umbilical vein endothelial cells

    Oxidative stress can induce cell injury in vascular endothelial cells, which is the initial event in the development of atherosclerosis. Although quantitative real-time polymerase chain reaction (qRT-PCR) has ...

    Tianyi Li, Hongying Diao, Lei Zhao, Yue Xing, Jichang Zhang, Ning Liu, Youyou Yan, Xin Tian, Wei Sun and Bin Liu

    BMC Molecular Biology 2017 18:10

    Published on: 5 April 2017

  11. Research article

    RUNX1 induces DNA replication independent active DNA demethylation at SPI1 regulatory regions

    SPI1 is an essential transcription factor (TF) for the hematopoietic lineage, in which its expression is tightly controlled through a −17-kb upstream regulatory region and a promoter region. Both regulatory re...

    Shubham Goyal, Takahiro Suzuki, Jing-Ru Li, Shiori Maeda, Mami Kishima, Hajime Nishimura, Yuri Shimizu and Harukazu Suzuki

    BMC Molecular Biology 2017 18:9

    Published on: 4 April 2017

    The Erratum to this article has been published in BMC Molecular Biology 2017 18:11

  12. Research article

    Immunoglobulin T from sea bass (Dicentrarchus labrax L.): molecular characterization, tissue localization and expression after nodavirus infection

    Immunoglobulins (Igs) are fundamental components of the adaptive immune system of vertebrates, with the IgT/IgZ isotype specific of Teleosts. In this paper we describe the identification of an IgT heavy chain ...

    Francesco Buonocore, Valentina Stocchi, Noelia Nunez-Ortiz, Elisa Randelli, Marco Gerdol, Alberto Pallavicini, Angelo Facchiano, Chiara Bernini, Laura Guerra, Giuseppe Scapigliati and Simona Picchietti

    BMC Molecular Biology 2017 18:8

    Published on: 15 March 2017

  13. Research article

    Properties of STAT1 and IRF1 enhancers and the influence of SNPs

    STAT1 and IRF1 collaborate to induce interferon-γ (IFNγ) stimulated genes (ISGs), but the extent to which they act alone or together is unclear. The effect of single nucleotide polymorphisms (SNPs) on in vivo ...

    Mohamed Abou El Hassan, Katherine Huang, Manoja B. K. Eswara, Zhaodong Xu, Tao Yu, Arthur Aubry, Zuyao Ni, Izzy Livne-bar, Monika Sangwan, Mohamad Ahmad and Rod Bremner

    BMC Molecular Biology 2017 18:6

    Published on: 9 March 2017

  14. Methodology article

    Methylated site display (MSD)-AFLP, a sensitive and affordable method for analysis of CpG methylation profiles

    It has been pointed out that environmental factors or chemicals can cause diseases that are developmental in origin. To detect abnormal epigenetic alterations in DNA methylation, convenient and cost-effective ...

    Toshiki Aiba, Toshiyuki Saito, Akiko Hayashi, Shinji Sato, Harunobu Yunokawa, Toru Maruyama, Wataru Fujibuchi, Hisaka Kurita, Chiharu Tohyama and Seiichiroh Ohsako

    BMC Molecular Biology 2017 18:7

    Published on: 9 March 2017

  15. Research article

    Identification of microRNAs and their response to the stress of plant allelochemicals in Aphis gossypii (Hemiptera: Aphididae)

    MicroRNAs (miRNAs) are a group of short non-coding RNAs involved in the inhibition of protein translation or in mRNA degradation. Although the regulatory roles of miRNAs in various biological processes have be...

    Kang-Sheng Ma, Fen Li, Ying Liu, Ping-Zhuo Liang, Xue-Wei Chen and Xi-Wu Gao

    BMC Molecular Biology 2017 18:5

    Published on: 16 February 2017

  16. Research article

    Binding affinity of five PBPs to Ostrinia sex pheromones

    Pheromone binding proteins (PBPs) of male Lepidoptera function in chemical communication, mate attraction and recognition. Directional selection was previously predicted between PBP3 orthologs of Ostrinia furnaca...

    Tiantao Zhang, Yaqi Sun, Kevin W. Wanner, Brad S. Coates, Kanglai He and Zhenying Wang

    BMC Molecular Biology 2017 18:4

    Published on: 7 February 2017

  17. Research article

    Transcriptional regulation of human sperm-associated antigen 16 gene by S-SOX5

    The mammalian sperm-associated antigen 16 gene (Spag16) uses alternative promoters to produce two major transcript isoforms (Spag16L and Spag16S) and encode proteins that are involved in the cilia/flagella format...

    Ling Zhang, Yunhao Liu, Wei Li, Qiaoling Zhang, Yanwei Li, Junpin Liu, Jie Min, Chaofan Shuang, Shizheng Song and Zhibing Zhang

    BMC Molecular Biology 2017 18:2

    Published on: 31 January 2017

  18. Research article

    Novel insight into the composition of human single-stranded DNA-binding protein 1 (hSSB1)-containing protein complexes

    Single-stranded DNA-binding proteins are essential cellular components required for the protection, metabolism and processing of single-stranded DNA. Human single-stranded DNA-binding protein 1 (hSSB1) is one ...

    Nicholas W. Ashton, Dorothy Loo, Nicolas Paquet, Kenneth J. O’Byrne and Derek J. Richard

    BMC Molecular Biology 2016 17:24

    Published on: 9 December 2016

  19. Methodology article

    3C-digital PCR for quantification of chromatin interactions

    Chromosome conformation capture (3C) is a powerful and widely used technique for detecting the physical interactions between chromatin regions in vivo. The principle of 3C is to convert physical chromatin inte...

    Meijun Du and Liang Wang

    BMC Molecular Biology 2016 17:23

    Published on: 6 December 2016

  20. Research article

    Distinct recruitment of human eIF4E isoforms to processing bodies and stress granules

    Eukaryotic translation initiation factor 4E (eIF4E) plays a pivotal role in the control of cap-dependent translation initiation, modulates the fate of specific mRNAs, occurs in processing bodies (PBs) and is r...

    Klara Frydryskova, Tomas Masek, Katerina Borcin, Silvia Mrvova, Veronica Venturi and Martin Pospisek

    BMC Molecular Biology 2016 17:21

    Published on: 30 August 2016

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