Translation and post-transcriptional regulation

Section edited by Christian Zwieb

This section will consider submissions with a focus on the mechanisms and regulation of translation, RNA processing, splicing and polyadenylation, RNA structure and RNA fold, RNA interference and gene silencing, and structure-function of regulatory RNAs.

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  1. Research article

    Distinct recruitment of human eIF4E isoforms to processing bodies and stress granules

    Eukaryotic translation initiation factor 4E (eIF4E) plays a pivotal role in the control of cap-dependent translation initiation, modulates the fate of specific mRNAs, occurs in processing bodies (PBs) and is r...

    Klara Frydryskova, Tomas Masek, Katerina Borcin, Silvia Mrvova, Veronica Venturi and Martin Pospisek

    BMC Molecular Biology 2016 17:21

    Published on: 30 August 2016

  2. Research article

    A potential role for protein palmitoylation and zDHHC16 in DNA damage response

    Cells respond to DNA damage by activating the phosphatidylinositol-3 kinase-related kinases, p53 and other pathways to promote cell cycle arrest, apoptosis, and/or DNA repair. Here we report that protein palmi...

    Na Cao, Jia-Kai Li, Yu-Qing Rao, Huijuan Liu, Ji Wu, Baojie Li, Peiquan Zhao, Li Zeng and Jing Li

    BMC Molecular Biology 2016 17:12

    Published on: 10 May 2016

  3. Research article

    Mice lacking microRNAs in Pax8-expressing cells develop hypothyroidism and end-stage renal failure

    Non-coding RNAs have gained increasing attention during the last decade. The first large group of non-coding RNAs to be characterized systematically starting at the beginning of the 21st century were small oli...

    Malte P. Bartram, Elena Amendola, Thomas Benzing, Bernhard Schermer, Gabriella de Vita and Roman-Ulrich Müller

    BMC Molecular Biology 2016 17:11

    Published on: 18 April 2016

  4. Research article

    Deciphering targeting rules of splicing modulator compounds: case of TG003

    Recent advances in the development of small chemical compounds that can modulate RNA splicing brought excitement to the field of splicing-targeting therapy. Splicing-targeting therapy tries to ameliorate the d...

    Maki Sakuma, Kei Iida and Masatoshi Hagiwara

    BMC Molecular Biology 2015 16:16

    Published on: 24 September 2015

  5. Research article

    Ribonomic analysis of human DZIP1 reveals its involvement in ribonucleoprotein complexes and stress granules

    DZIP1 (DAZ-interacting protein 1) has been described as a component of the Hh signaling pathway with a putative regulatory role in ciliogenesis. DZIP1 interacts with DAZ RNA binding proteins in embryonic stem ...

    Patrícia ShigunovShigunov, Jose Sotelo-Silveira, Marco Augusto Stimamiglio, Crisciele Kuligovski, Florencia Irigoín, Jose L Badano, David Munroe, Alejandro Correa and Bruno Dallagiovanna

    BMC Molecular Biology 2014 15:12

    Published on: 3 July 2014

  6. Methodology article

    A novel, non-radioactive eukaryotic in vitro transcription assay for sensitive quantification of RNA polymerase II activity

    Many studies of the eukaryotic transcription mechanism and its regulation rely on in vitro assays. Conventional RNA polymerase II transcription assays are based on radioactive labelling of the newly synthesized R...

    Cristina Voss, Brita Schmitt, Susanne Werner-Simon, Christian Lutz, Werner Simon and Jan Anderl

    BMC Molecular Biology 2014 15:7

    Published on: 3 April 2014

  7. Research article

    Molecular cloning and RNA interference-mediated functional characterization of a Halloween gene spook in the white-backed planthopper Sogatella furcifera

    Ecdysteroid hormones ecdysone and 20-hydroxyecdysone play fundamental roles in insect postembryonic development and reproduction. Five cytochrome P450 monooxygenases (CYPs), encoded by Halloween genes, have be...

    Shuang Jia, Pin-Jun Wan, Li-Tao Zhou, Li-Li Mu and Guo-Qing Li

    BMC Molecular Biology 2013 14:19

    Published on: 4 September 2013

  8. Research article

    APOBEC3 inhibits DEAD-END function to regulate microRNA activity

    The RNA binding protein DEAD-END (DND1) is one of the few proteins known to regulate microRNA (miRNA) activity at the level of miRNA-mRNA interaction. DND1 blocks miRNA interaction with the 3′-untranslated reg...

    Sara Ali, Namrata Karki, Chitralekha Bhattacharya, Rui Zhu, Donna A MacDuff, Mark D Stenglein, April J Schumacher, Zachary L Demorest, Reuben S Harris, Angabin Matin and Sita Aggarwal

    BMC Molecular Biology 2013 14:16

    Published on: 26 July 2013

  9. Research article

    Loss of CARM1 is linked to reduced HuR function in replicative senescence

    The co-activator-associated arginine methyltransferase 1 (CARM1) catalyzes the methylation of HuR. However, the functional impact of this modification is not fully understood. Here, we investigated the influen...

    Lijun Pang, Haiyan Tian, Na Chang, Jie Yi, Lixiang Xue, Bin Jiang, Myriam Gorospe, Xiaowei Zhang and Wengong Wang

    BMC Molecular Biology 2013 14:15

    Published on: 9 July 2013

  10. Research article

    Tip110 interacts with YB-1 and regulates each other’s function

    Tip110 plays important roles in tumor immunobiology, pre-mRNA splicing, expression regulation of viral and host genes, and possibly protein turnover. It is clear that our understanding of Tip110 biological fun...

    Khalid Amine Timani, Ying Liu and Johnny J He

    BMC Molecular Biology 2013 14:14

    Published on: 4 July 2013

  11. Research article

    Identification of differences in microRNA transcriptomes between porcine oxidative and glycolytic skeletal muscles

    MicroRNAs (miRNAs) are a type of non-coding small RNA ~22 nucleotides in length that regulate the expression of protein coding genes at the post-transcriptional level. Glycolytic and oxidative myofibers, the t...

    Yingkai Liu, Mingzhou Li, Jideng Ma, Jie Zhang, Chaowei Zhou, Tao Wang, Xiaolian Gao and Xuewei Li

    BMC Molecular Biology 2013 14:7

    Published on: 18 February 2013

  12. Research article

    Multiple tandem splicing silencer elements suppress aberrant splicing within the long exon 26 of the human Apolipoprotein B gene

    Apolipoprotein B (APOB) is an integral component of the chylomicron and the atherogenic lipoproteins LDL and Lp(a). Exon 26 of the APOB pre-mRNA is unusually long at 7,572 nt and is constitutively spliced. It is ...

    Umasuthan Srirangalingam, Scott A Akker, Dennis Norman, Naveenan Navaratnam, Shern L Chew and Bernard Khoo

    BMC Molecular Biology 2013 14:5

    Published on: 7 February 2013

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