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Translation and post-transcriptional regulation

Section edited by Jacek Wower

This section will consider submissions with a focus on the mechanisms and regulation of translation, RNA processing, splicing and polyadenylation, RNA structure and RNA fold, RNA interference and gene silencing, and structure-function of regulatory RNAs.

  1. Obesity and nonalcoholic steatohepatitis (NASH) are well-known risk factors of hepatocellular carcinoma (HCC). The lipid-rich environment enhances the proliferation and metastasis abilities of tumor cells. Pre...

    Authors: Yanjie Tan, Yi Jin, Xiang Wu and Zhuqing Ren

    Citation: BMC Molecular Biology 2019 20:24

    Content type: Research article

    Published on:

  2. The BACE1 antisense transcript (BACE1-AS) is a conserved long noncoding RNA (lncRNA). The level of BACE1-AS is significantly increased and the level of the BACE1 mRNA is slightly increased in subjects with AD....

    Authors: Fan Li, Yun Wang, Hui Yang, Yingying Xu, Xiaoyan Zhou, Xiao Zhang, Zhaohong Xie and Jianzhong Bi

    Citation: BMC Molecular Biology 2019 20:23

    Content type: Research article

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  3. The current study aimed to investigate the effects of miR-32-5p on cardiac fibroblasts (CFs) that were induced with high levels of glucose; we also aimed to identify the potential mechanisms involved in the re...

    Authors: Jie Shen, Wanhong Xing, Rui Liu, Yiying Zhang, Chunhong Xie and Fangqi Gong

    Citation: BMC Molecular Biology 2019 20:21

    Content type: Research article

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  4. Many miRNA functions have been revealed to date. Single miRNAs can participate in life processes by regulating more than one target gene, and more than one miRNA can also simultaneously act on one target mRNA....

    Authors: Zhiwei Zhu, Yueyue Ma, Yuan Li, Zhixue Cheng, Huifeng Li, Lihuan Zhang, Dongmei Xu and Pengfei Li

    Citation: BMC Molecular Biology 2019 20:19

    Content type: Research article

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  5. Camels possess the characteristics of salt- and drought-resistances, due to the long-time adaption to the living environment in desert. The camel resistance research on transcriptome is rare and deficient, esp...

    Authors: Yu Cao, Dong Zhang and Huanmin Zhou

    Citation: BMC Molecular Biology 2019 20:11

    Content type: Research article

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  6. Isatis indigotica, a traditional Chinese medicine, produces a variety of active ingredients. However, little is known about the key genes and corresponding expression profiling involved in the biosynthesis pathwa...

    Authors: Renjun Qu, Yujing Miao, Yingjing Cui, Yiwen Cao, Ying Zhou, Xiaoqing Tang, Jie Yang and Fangquan Wang

    Citation: BMC Molecular Biology 2019 20:9

    Content type: Research article

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  7. Woronin bodies are fungal-specific organelles whose formation is derived from peroxisomes. The former are believed to be involved in the regulation of mycotoxins biosynthesis, but not in their damage repair fu...

    Authors: Jun Yuan, Ding Li, Ling Qin, Jiaojiao Shen, Xiaodong Guo, Elisabeth Tumukunde, Mingzhu Li and Shihua Wang

    Citation: BMC Molecular Biology 2019 20:4

    Content type: Research article

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  8. Physical exercise can improve brain function by altering brain gene expression. The expression mechanisms underlying the brain’s response to exercise still remain unknown. miRNAs as vital regulators of gene ex...

    Authors: Yanhong Zhao, Anmin Zhang, Yanfang Wang, Shuping Hu, Ruiping Zhang and Shuaiwei Qian

    Citation: BMC Molecular Biology 2019 20:3

    Content type: Research article

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  9. Glioblastoma (GB) is the most common and aggressive tumor of the brain. Genotype-based approaches and independent analyses of the transcriptome or the proteome have led to progress in understanding the underly...

    Authors: Jean-Michel Lemée, Anne Clavreul, Marc Aubry, Emmanuelle Com, Marie de Tayrac, Jean Mosser and Philippe Menei

    Citation: BMC Molecular Biology 2018 19:13

    Content type: Research article

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  10. Gastric cancer is the third leading cause of cancer-related mortality worldwide. Recently, it has been demonstrated that gastric cancer cells display a specific miRNA expression profile, with increasing eviden...

    Authors: Joana Filipa Lima, Joana Carvalho, Inês Pinto-Ribeiro, Carina Almeida, Jesper Wengel, Laura Cerqueira, Céu Figueiredo, Carla Oliveira and Nuno Filipe Azevedo

    Citation: BMC Molecular Biology 2018 19:6

    Content type: Research article

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  11. Messenger RNA (mRNA) represents a small percentage of RNAs in a cell, with ribosomal RNA (rRNA) making up the bulk of it. To isolate mRNA from eukaryotes, typically poly-A selection is carried out. Recently, a...

    Authors: Jacob Fleischmann and Miguel A. Rocha

    Citation: BMC Molecular Biology 2018 19:1

    Content type: Research article

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  12. Cholangiocarcinoma is one of the deadly disease with poor 5-year survival and poor response to conventional therapies. Previously, we found that p27kip1 nuclear-cytoplasmic translocation confers proliferation ...

    Authors: Jun Yang, Yan Liu, Bing Wang, Hongzhen Lan, Ying Liu, Fei Chen, Ju Zhang and Jian Luo

    Citation: BMC Molecular Biology 2017 18:23

    Content type: Research article

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  13. RBM10 is an RNA binding protein involved in message stabilization and alternative splicing regulation. The objective of the research described herein was to identify novel targets of RBM10-regulated splicing. ...

    Authors: Leslie C. Sutherland, Philippe Thibault, Mathieu Durand, Elvy Lapointe, Jose M. Knee, Ariane Beauvais, Irina Kalatskaya, Sarah C. Hunt, Julie J. Loiselle, Justin G. Roy, Sarah J. Tessier, Gustavo Ybazeta, Lincoln Stein, Rashmi Kothary, Roscoe Klinck and Benoit Chabot

    Citation: BMC Molecular Biology 2017 18:19

    Content type: Research article

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  14. Eukaryotic translation initiation factor 4E (eIF4E) plays a pivotal role in the control of cap-dependent translation initiation, modulates the fate of specific mRNAs, occurs in processing bodies (PBs) and is r...

    Authors: Klara Frydryskova, Tomas Masek, Katerina Borcin, Silvia Mrvova, Veronica Venturi and Martin Pospisek

    Citation: BMC Molecular Biology 2016 17:21

    Content type: Research article

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  15. Serine–arginine rich splicing factor 2 (SRSF2) is a protein known for its role in RNA splicing and genome stability. It has been recently discovered that SRSF2, along with other splicing regulators, is frequen...

    Authors: Lindsey Skrdlant, Jeremy M. Stark and Ren-Jang Lin

    Citation: BMC Molecular Biology 2016 17:18

    Content type: Research article

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  16. Cells respond to DNA damage by activating the phosphatidylinositol-3 kinase-related kinases, p53 and other pathways to promote cell cycle arrest, apoptosis, and/or DNA repair. Here we report that protein palmi...

    Authors: Na Cao, Jia-Kai Li, Yu-Qing Rao, Huijuan Liu, Ji Wu, Baojie Li, Peiquan Zhao, Li Zeng and Jing Li

    Citation: BMC Molecular Biology 2016 17:12

    Content type: Research article

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  17. Non-coding RNAs have gained increasing attention during the last decade. The first large group of non-coding RNAs to be characterized systematically starting at the beginning of the 21st century were small oli...

    Authors: Malte P. Bartram, Elena Amendola, Thomas Benzing, Bernhard Schermer, Gabriella de Vita and Roman-Ulrich Müller

    Citation: BMC Molecular Biology 2016 17:11

    Content type: Research article

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  18. mRNA binding proteins (RBPs) constitute 10–15 % of the eukaryotic proteome and play important part in post-transcriptional regulation of gene expression. Due to the instability of RNA and the transient nature ...

    Authors: Nitzan Samra, Avigail Atir-Lande, Lilach Pnueli and Yoav Arava

    Citation: BMC Molecular Biology 2015 16:17

    Content type: Research article

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  19. Wingless gene (Wg) plays a fundamental role in regulating the segment polarity and wing imaginal discs of insects. The rice planthoppers have an obvious wing dimorphism, and the long- and short-winged forms exist...

    Authors: Ju-Long Yu, Zhi-Fang An and Xiang-Dong Liu

    Citation: BMC Molecular Biology 2014 15:20

    Content type: Research article

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  20. Trans-translation is catalyzed by ribonucleprotein complexes composed of SmpB protein and transfer-messenger RNA. They release stalled ribosomes from truncated mRNAs and tag defective proteins for proteolytic deg...

    Authors: Iwona K Wower, Christian Zwieb and Jacek Wower

    Citation: BMC Molecular Biology 2014 15:19

    Content type: Research article

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  21. DZIP1 (DAZ-interacting protein 1) has been described as a component of the Hh signaling pathway with a putative regulatory role in ciliogenesis. DZIP1 interacts with DAZ RNA binding proteins in embryonic stem ...

    Authors: Patrícia ShigunovShigunov, Jose Sotelo-Silveira, Marco Augusto Stimamiglio, Crisciele Kuligovski, Florencia Irigoín, Jose L Badano, David Munroe, Alejandro Correa and Bruno Dallagiovanna

    Citation: BMC Molecular Biology 2014 15:12

    Content type: Research article

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  22. Many studies of the eukaryotic transcription mechanism and its regulation rely on in vitro assays. Conventional RNA polymerase II transcription assays are based on radioactive labelling of the newly synthesized R...

    Authors: Cristina Voss, Brita Schmitt, Susanne Werner-Simon, Christian Lutz, Werner Simon and Jan Anderl

    Citation: BMC Molecular Biology 2014 15:7

    Content type: Methodology article

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  23. Alternative splicing contributes to the diversity of the proteome, and provides the cell with an important additional layer of regulation of gene expression. Among the many RNA binding proteins that regulate a...

    Authors: Christopher Edge, Clare Gooding and Christopher WJ Smith

    Citation: BMC Molecular Biology 2013 14:29

    Content type: Research article

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  24. Ecdysteroid hormones ecdysone and 20-hydroxyecdysone play fundamental roles in insect postembryonic development and reproduction. Five cytochrome P450 monooxygenases (CYPs), encoded by Halloween genes, have be...

    Authors: Shuang Jia, Pin-Jun Wan, Li-Tao Zhou, Li-Li Mu and Guo-Qing Li

    Citation: BMC Molecular Biology 2013 14:19

    Content type: Research article

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  25. The RNA binding protein DEAD-END (DND1) is one of the few proteins known to regulate microRNA (miRNA) activity at the level of miRNA-mRNA interaction. DND1 blocks miRNA interaction with the 3′-untranslated reg...

    Authors: Sara Ali, Namrata Karki, Chitralekha Bhattacharya, Rui Zhu, Donna A MacDuff, Mark D Stenglein, April J Schumacher, Zachary L Demorest, Reuben S Harris, Angabin Matin and Sita Aggarwal

    Citation: BMC Molecular Biology 2013 14:16

    Content type: Research article

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  26. The co-activator-associated arginine methyltransferase 1 (CARM1) catalyzes the methylation of HuR. However, the functional impact of this modification is not fully understood. Here, we investigated the influen...

    Authors: Lijun Pang, Haiyan Tian, Na Chang, Jie Yi, Lixiang Xue, Bin Jiang, Myriam Gorospe, Xiaowei Zhang and Wengong Wang

    Citation: BMC Molecular Biology 2013 14:15

    Content type: Research article

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  27. Tip110 plays important roles in tumor immunobiology, pre-mRNA splicing, expression regulation of viral and host genes, and possibly protein turnover. It is clear that our understanding of Tip110 biological fun...

    Authors: Khalid Amine Timani, Ying Liu and Johnny J He

    Citation: BMC Molecular Biology 2013 14:14

    Content type: Research article

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  28. Ribosomal protein L30 belongs to the L7Ae family of RNA-binding proteins, which recognize diverse targets. L30 binds to kink-turn motifs in the 28S ribosomal RNA, L30 pre-mRNA, and mature L30 mRNA. L30 has a n...

    Authors: Abby L Bifano, Tarik Atassi, Tracey Ferrara and Donna M Driscoll

    Citation: BMC Molecular Biology 2013 14:12

    Content type: Research article

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  29. MicroRNAs (miRNAs) are a type of non-coding small RNA ~22 nucleotides in length that regulate the expression of protein coding genes at the post-transcriptional level. Glycolytic and oxidative myofibers, the t...

    Authors: Yingkai Liu, Mingzhou Li, Jideng Ma, Jie Zhang, Chaowei Zhou, Tao Wang, Xiaolian Gao and Xuewei Li

    Citation: BMC Molecular Biology 2013 14:7

    Content type: Research article

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  30. Apolipoprotein B (APOB) is an integral component of the chylomicron and the atherogenic lipoproteins LDL and Lp(a). Exon 26 of the APOB pre-mRNA is unusually long at 7,572 nt and is constitutively spliced. It is ...

    Authors: Umasuthan Srirangalingam, Scott A Akker, Dennis Norman, Naveenan Navaratnam, Shern L Chew and Bernard Khoo

    Citation: BMC Molecular Biology 2013 14:5

    Content type: Research article

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  31. Alternative splicing is often subjected to complex regulatory control that involves many protein factors and cis-acting RNA sequence elements. One major challenge is to identify all of the protein players and def...

    Authors: Victoria A Fleming, Cuiyu Geng, Andrea N Ladd and Hua Lou

    Citation: BMC Molecular Biology 2012 13:35

    Content type: Research article

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  32. Adenylate kinase 2 (AK2) is a phosphotransferase that catalyzes the reversible reaction 2ADP(GDP) ↔ ATP(GTP) + AMP and influences cellular energy homeostasis. However, the role of AK2 in regulating cell prolif...

    Authors: Ru-Ping Chen, Chun-Yan Liu, Hong-Lian Shao, Wei-Wei Zheng, Jin-Xing Wang and Xiao-Fan Zhao

    Citation: BMC Molecular Biology 2012 13:31

    Content type: Research article

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  33. RNA ligases are essential reagents for many methods in molecular biology including NextGen RNA sequencing. To prevent ligation of RNA to itself, ATP independent mutant ligases, defective in self-adenylation, a...

    Authors: Alexander M Zhelkovsky and Larry A McReynolds

    Citation: BMC Molecular Biology 2012 13:24

    Content type: Research article

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  34. Glial cell line-derived neurotrophic factor (GDNF) is a potent survival factor for many cell types, and its expression is widespread both within and outside of the nervous system. The regulation of GDNF expres...

    Authors: Kentaro Oh-hashi, Yoko Hirata and Kazutoshi Kiuchi

    Citation: BMC Molecular Biology 2012 13:2

    Content type: Research article

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