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  1. The Myc oncoprotein is a transcriptional regulator whose function is essential for normal development. Myc is capable of binding to 10% of the mammalian genome, and it is unclear how a developing embryo contro...

    Authors: Julie M Goodliffe, Michael D Cole and Eric Wieschaus

    Citation: BMC Molecular Biology 2007 8:40

    Content type: Research article

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  2. Methionine sulfoxide reductases (Msrs) are enzymes that catalyze the reduction of oxidized methionine residues. Most organisms that were genetically modified to lack the MsrA gene have shown shortening of their l...

    Authors: Antonella De Luca, Paolo Sacchetta, Marzia Nieddu, Carmine Di Ilio and Bartolo Favaloro

    Citation: BMC Molecular Biology 2007 8:39

    Content type: Research article

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  3. Previous studies suggest that human RAD9 (hRad9), encoding a DNA damage checkpoint molecule, which is frequently amplified in epithelial tumor cells of breast, lung, head and neck cancer, participates in regulati...

    Authors: Kazuhiro Ishikawa, Hideshi Ishii, Yoshiki Murakumo, Koshi Mimori, Masahiko Kobayashi, Ken-ichi Yamamoto, Masaki Mori, Hiroshi Nishino, Yusuke Furukawa and Keiichi Ichimura

    Citation: BMC Molecular Biology 2007 8:37

    Content type: Research article

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  4. Topoisomerase IIα has been shown to be down-regulated in doxorubicin-resistant cell lines. The specificity proteins Sp1 and Sp3 have been implicated in regulation of topoisomerase IIα transcription, although t...

    Authors: Amram O Williams, Richard J Isaacs and Kathryn M Stowell

    Citation: BMC Molecular Biology 2007 8:36

    Content type: Research article

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  5. In Drosophila melanogaster dosage compensation of most X-linked genes is mediated by the male-specific lethal (MSL) complex, which includes MOF. MOF acetylates histone H4 at lysine 16 (H4K16ac). The X-linked Larv...

    Authors: Vikki M Weake and Maxwell J Scott

    Citation: BMC Molecular Biology 2007 8:35

    Content type: Research article

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  6. The dystroglycan (DG) complex is a major non-integrin cell adhesion system whose multiple biological roles involve, among others, skeletal muscle stability, embryonic development and synapse maturation. DG is ...

    Authors: Ernesto Pavoni, Davide Cacchiarelli, Roberta Tittarelli, Massimiliano Orsini, Antonio Galtieri, Bruno Giardina and Andrea Brancaccio

    Citation: BMC Molecular Biology 2007 8:34

    Content type: Research article

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  7. The main vector for transmission of malaria in India is the Anopheles culicifacies mosquito species, a naturally selected subgroup of which is completely refractory (R) to transmission of the malaria parasite, Pl...

    Authors: Janneth Rodrigues, Neema Agrawal, Anil Sharma, Pawan Malhotra, Tridibes Adak, Virander S Chauhan and Raj K Bhatnagar

    Citation: BMC Molecular Biology 2007 8:33

    Content type: Research article

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  8. the use of specific but partially degenerate primers for nucleic acid hybridisations and PCRs amplification of known or unknown gene families was first reported well over a decade ago and the technique has bee...

    Authors: Zhensheng Pan, Richard Barry, Alexey Lipkin and Mikhail Soloviev

    Citation: BMC Molecular Biology 2007 8:32

    Content type: Research article

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  9. Development in higher eukaryotes involves programmed gene expression. Cell type-specific gene expression is established during this process and is inherited in succeeding cell cycles. Higher eukaryotes have ev...

    Authors: Li Xin, Guo-Ling Zhou, Wei Song, Xue-Song Wu, Gong-Hong Wei, De-Long Hao, Xiang Lv, De-Pei Liu and Chih-Chuan Liang

    Citation: BMC Molecular Biology 2007 8:31

    Content type: Research article

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  10. The ability to regulate transgene expression has many applications, mostly concerning the analysis of gene function. Desirable induction characteristics, such as low un-induced expression, high induced express...

    Authors: Rachel Brough, Antigoni M Papanastasiou and Andrew CG Porter

    Citation: BMC Molecular Biology 2007 8:30

    Content type: Methodology article

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  11. ATM and PARP-1 are two of the most important players in the cell's response to DNA damage. PARP-1 and ATM recognize and bound to both single and double strand DNA breaks in response to different triggers. Here...

    Authors: Rocío Aguilar-Quesada, José Antonio Muñoz-Gámez, David Martín-Oliva, Andreína Peralta, Ma Teresa Valenzuela, Rubén Matínez-Romero, Rosa Quiles-Pérez, Josiane Menissier-de Murcia, Gilbert de Murcia, Mariano Ruiz de Almodóvar and F Javier Oliver

    Citation: BMC Molecular Biology 2007 8:29

    Content type: Research article

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  12. KSRP is a AU-rich element (ARE) binding protein that causes decay of select sets of transcripts in different cell types. We have recently described that phosphatidylinositol 3-kinase/AKT (PI3K-AKT) activation ...

    Authors: Tina Ruggiero, Michele Trabucchi, Marco Ponassi, Giorgio Corte, Ching-Yi Chen, Latifa al-Haj, Khalid SA Khabar, Paola Briata and Roberto Gherzi

    Citation: BMC Molecular Biology 2007 8:28

    Content type: Research article

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  13. Initiation of eukaryotic DNA replication involves many protein-protein and protein-DNA interactions. We have previously shown that 14-3-3 proteins bind cruciform DNA and associate with mammalian and yeast repl...

    Authors: Wafaa Yahyaoui, Mario Callejo, Gerald B Price and Maria Zannis-Hadjopoulos

    Citation: BMC Molecular Biology 2007 8:27

    Content type: Research article

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  14. Giardia intestinalis is a protist found in freshwaters worldwide, and is the most common cause of parasitic diarrhea in humans. The phylogenetic position of this parasite is still much debated. Histones are small...

    Authors: Janet Yee, Anita Tang, Wei-Ling Lau, Heather Ritter, Dewald Delport, Melissa Page, Rodney D Adam, Miklós Müller and Gang Wu

    Citation: BMC Molecular Biology 2007 8:26

    Content type: Research article

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  15. To discover prostate cancer biomarkers, we profiled gene expression in benign and malignant cells laser capture microdissected (LCM) from prostate tissues and metastatic prostatic adenocarcinomas. Here we pres...

    Authors: Dagmar M Kube, Cemile D Savci-Heijink, Anne-Françoise Lamblin, Farhad Kosari, George Vasmatzis, John C Cheville, Donald P Connelly and George G Klee

    Citation: BMC Molecular Biology 2007 8:25

    Content type: Methodology article

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  16. Encephalitozoon cuniculi is a member of a distinctive group of single-celled parasitic eukaryotes called microsporidia, which are closely related to fungi. Some of these organisms, including E. cuniculi, also hav...

    Authors: Erin E Gill and Naomi M Fast

    Citation: BMC Molecular Biology 2007 8:24

    Content type: Research article

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  17. The ubiquitin-proteasome system is the predominant pathway for myofibrillar proteolysis but a previous study in C2C12 myotubes only observed alterations in lysosome-dependent proteolysis in response to complet...

    Authors: Fouzia Sadiq, David G Hazlerigg and Michael A Lomax

    Citation: BMC Molecular Biology 2007 8:23

    Content type: Research article

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  19. We investigated the molecular basis of primary open-angle glaucoma (POAG) using Opticin (OPTC) as a candidate gene on the basis of its expression in the trabecular meshwork cells involved in the disease pathogene...

    Authors: Moulinath Acharya, Suddhasil Mookherjee, Ashima Bhattacharjee, Sanjay KD Thakur, Arun K Bandyopadhyay, Abhijit Sen, Subhabrata Chakrabarti and Kunal Ray

    Citation: BMC Molecular Biology 2007 8:21

    Content type: Research article

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  20. Podoplanin is a membrane mucin that, among a series of tissues, is expressed on late osteoblasts and osteocytes. Since recent findings have focussed on podoplanin's potential role as a tumour progression facto...

    Authors: Brigitte Hantusch, Romana Kalt, Sigurd Krieger, Christina Puri and Dontscho Kerjaschki

    Citation: BMC Molecular Biology 2007 8:20

    Content type: Research article

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  21. The calsarcins comprise a novel family of muscle-specific calcineurin-interaction proteins that play an important role in modulating both the function and substrate specificity of calcineurin in muscle cells. ...

    Authors: Heng Wang, Shulin Yang, E Yang, Zhengmao Zhu, Yulian Mu, Shutang Feng and Kui Li

    Citation: BMC Molecular Biology 2007 8:19

    Content type: Research article

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  22. The genetic basis of telomere length heterogeneity among mammalian species is still not well understood. Recently, a gene named regulator of telomere length elongation helicase (RTEL) was identified and predicted...

    Authors: Zhuo Du, DingSheng Zhao, YongHui Zhao, ShaoHua Wang, Yu Gao and Ning Li

    Citation: BMC Molecular Biology 2007 8:18

    Content type: Research article

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  24. A diverse set of transcripts called 185/333 is strongly expressed in sea urchins responding to immune challenge. Optimal alignments of full-length 185/333 cDNAs requires the insertion of large gaps that define 25...

    Authors: David P Terwilliger, Katherine M Buckley, Virginia Brockton, Nicole J Ritter and L Courtney Smith

    Citation: BMC Molecular Biology 2007 8:16

    Content type: Research article

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  25. In eukaryotic cells, each molecule of H/ACA small nucleolar RNA (snoRNA) assembles with four evolutionarily conserved core proteins to compose a specific ribonucleoprotein particle. One of the four core compon...

    Authors: Sara Riccardo, Giuseppe Tortoriello, Ennio Giordano, Mimmo Turano and Maria Furia

    Citation: BMC Molecular Biology 2007 8:15

    Content type: Research article

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  26. The trophoblast Kunitz domain proteins (TKDPs) constitute a highly expressed, placenta-specific, multigene family restricted to ruminant ungulates and characterized by a C-terminal "Kunitz" domain, preceded by...

    Authors: Anindita Chakrabarty and R Michael Roberts

    Citation: BMC Molecular Biology 2007 8:14

    Content type: Research article

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  27. Chondroprotective agents (CPA) such as glucosamine, curcumin and diacerein represent potential remedies for the management of osteoarthritis and several studies have been performed on their effects in-vitro an...

    Authors: Stefan Toegel, Wenwen Huang, Claudia Piana, Frank M Unger, Michael Wirth, Mary B Goldring, Franz Gabor and Helmut Viernstein

    Citation: BMC Molecular Biology 2007 8:13

    Content type: Research article

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  28. Interleukin 4 (IL-4) has been shown to suppress interleukin-1 (IL-1) induced expression of matrix metalloproteinase-3 (MMP-3) in human synovial and gingival fibroblasts, but the mechanism of suppression has no...

    Authors: Denise Stewart, Masoud Javadi, Mariah Chambers, Chad Gunsolly, Grzegorz Gorski and Ruth C Borghaei

    Citation: BMC Molecular Biology 2007 8:12

    Content type: Research article

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  31. Single-stranded oligonucleotides (ssODN) are used routinely to direct specific base alterations within mammalian genomes that result in the restoration of a functional gene. Despite success with the technique,...

    Authors: Julia U Engstrom and Eric B Kmiec

    Citation: BMC Molecular Biology 2007 8:9

    Content type: Research article

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  32. The enhancer (Eμ3') of the immunoglobulin heavy chain locus (IGH) of the channel catfish (Ictalurus punctatus) has been well characterized. The functional core region consists of two variant Oct transcription fac...

    Authors: Mara L Lennard, Jun-ichi Hikima, David A Ross, Corine P Kruiswijk, Melanie R Wilson, Norman W Miller and Gregory W Warr

    Citation: BMC Molecular Biology 2007 8:8

    Content type: Research article

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  34. Nuclear import of proteins is typically mediated by their physical interaction with soluble cytosolic receptor proteins via a nuclear localization signal (NLS). A simple genetic assay to detect active NLSs bas...

    Authors: Kris S Marshall, Zhiying Zhang, Jennifer Curran, Stephanie Derbyshire and Joe S Mymryk

    Citation: BMC Molecular Biology 2007 8:6

    Content type: Methodology article

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  35. Scavenger receptor type B class I (SR-BI), ABC transporter A1 (ABCA1) -and G1 (ABCG1) all play important roles in the reverse cholesterol transport. Reverse cholesterol transport is a mechanism whereby the bod...

    Authors: Marita Sporstøl, Seyed Ali Mousavi, Winnie Eskild, Norbert Roos and Trond Berg

    Citation: BMC Molecular Biology 2007 8:5

    Content type: Research article

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  37. Apolipoprotein B (APOB) is an integral part of the LDL, VLDL, IDL, Lp(a) and chylomicron lipoprotein particles. The APOB pre-mRNA consists of 29 constitutively-spliced exons. APOB exists as two natural isoforms: ...

    Authors: Bernard Khoo, Xavier Roca, Shern L Chew and Adrian R Krainer

    Citation: BMC Molecular Biology 2007 8:3

    Content type: Research article

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  38. Despite of the fact that mammalian genomes are far more spacious than prokaryotic genomes, recent nucleotide sequencing data have revealed that many mammalian genes are arranged in a head-to-head orientation a...

    Authors: Ping-Yen Chen, Wun-Shaing W Chang, Ruey-Hwang Chou, Yiu-Kay Lai, Sheng-Chieh Lin, Chia-Yi Chi and Cheng-Wen Wu

    Citation: BMC Molecular Biology 2007 8:2

    Content type: Research article

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  39. Ucp3 is an integral protein of the inner mitochondrial membrane with a role in lipid metabolism preventing deleterious effects of fatty acids in states of high lipid oxidation. Ucp3 is expressed in brown adipose ...

    Authors: Tobias Fromme, Kathrin Reichwald, Matthias Platzer, Xing-Sheng Li and Martin Klingenspor

    Citation: BMC Molecular Biology 2007 8:1

    Content type: Research article

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  40. S100 proteins, a multigenic family of non-ubiquitous cytoplasmic Ca2+-binding proteins, have been linked to human pathologies in recent years. Dysregulated expression of S100 proteins, including S100A9, has been ...

    Authors: Jens Grote, Simone König, Doreen Ackermann, Claudia Sopalla, Malgorzata Benedyk, Marek Los and Claus Kerkhoff

    Citation: BMC Molecular Biology 2006 7:48

    Content type: Research article

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  41. Mycobacteriophage Ms6 integrates into Mycobacterium smegmatis and M. bovis BCG chromosome at the 3' end of tRNAala genes. Homologous recombination occurs between the phage attP core and the attB site located in t...

    Authors: Tiago Dos Vultos, Isabelle Méderlé, Valérie Abadie, Madalena Pimentel, José Moniz-Pereira, Brigitte Gicquel, Jean-Marc Reyrat and Nathalie Winter

    Citation: BMC Molecular Biology 2006 7:47

    Content type: Research article

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  42. Invitrogen Gateway technology exploits the integrase/att site-specific recombination system for directional cloning of PCR products and the subsequent subcloning into destination vectors. One or three DNA segment...

    Authors: Enrico Magnani, Linnea Bartling and Sarah Hake

    Citation: BMC Molecular Biology 2006 7:46

    Content type: Methodology article

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  43. Macrophages (Mθ) play a central role in the innate immune response and in the pathology of chronic inflammatory diseases. Macrophages treated with Th2-type cytokines such as Interleukin-4 (IL-4) and Interleuki...

    Authors: Kate Liddiard, John S Welch, Jean Lozach, Sven Heinz, Christopher K Glass and David R Greaves

    Citation: BMC Molecular Biology 2006 7:45

    Content type: Research article

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  44. DNA ligases are required for DNA strand joining in all forms of cellular life. NAD+-dependent DNA ligases are found primarily in eubacteria but also in some eukaryotic viruses, bacteriophage and archaea. Among th...

    Authors: Laetitia Poidevin and Stuart A MacNeill

    Citation: BMC Molecular Biology 2006 7:44

    Content type: Research article

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  45. Helicases play essential roles in many cellular processes including replication, transcription and translation. Most helicases translocate along one strand of the duplex while displacing the complementary stra...

    Authors: Jae-Ho Shin and Zvi Kelman

    Citation: BMC Molecular Biology 2006 7:43

    Content type: Methodology article

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  46. Visceral leishmaniasis caused by members of the Leishmania donovani complex is often fatal in the absence of treatment. Research has been hampered by the lack of good laboratory models and tools for genetic manip...

    Authors: Hubert Denise, Jacqueline Poot, Maribel Jiménez, Audrey Ambit, Daland C Herrmann, Arno N Vermeulen, Graham H Coombs and Jeremy C Mottram

    Citation: BMC Molecular Biology 2006 7:42

    Content type: Research article

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  48. By screening a plasmid library for proteins that could cause silencing when targeted to the HMR locus in Saccharomyces cerevisiae, we previously reported the identification of Rtt107/Esc4 based on its ability to

    Authors: David C Zappulla, Arindel SR Maharaj, Jessica J Connelly, Rebecca A Jockusch and Rolf Sternglanz

    Citation: BMC Molecular Biology 2006 7:40

    Content type: Research article

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  50. A large number of organisms have internal circadian clocks that enable them to adapt to the cyclic changes of the external environment. In the model organism Drosophila melanogaster, feedback loops of transcripti...

    Authors: Antonio CA Meireles-Filho, Paulo R Amoretty, Nataly A Souza, Charalambos P Kyriacou and Alexandre A Peixoto

    Citation: BMC Molecular Biology 2006 7:38

    Content type: Research article

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