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  1. Physiological long term adaptation of pancreatic beta cells is driven by stimuli such as glucose and incretin hormones acting via cAMP (e.g. GLP-1) and involves regulated gene expression. Several rapidly induc...

    Authors: Dominique A Glauser, Thierry Brun, Benoit R Gauthier and Werner Schlegel

    Citation: BMC Molecular Biology 2007 8:54

    Content type: Research article

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  2. Lipophorin receptors (LpRs) have been described in a number of insects, but functional studies have been reported only in locusts and mosquitoes. The aim of the present work was to characterize the LpR of the ...

    Authors: Laura Ciudad, Xavier Bellés and Maria-Dolors Piulachs

    Citation: BMC Molecular Biology 2007 8:53

    Content type: Research article

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  3. Zfra is a 31-amino-acid zinc finger-like protein, which is known to regulate cell death by tumor necrosis factor (TNF) and overexpressed TNF receptor- or Fas-associated death domain proteins (TRADD and FADD). ...

    Authors: Qunying Hong, Li-Jin Hsu, Lori Schultz, Nicole Pratt, Jeffrey Mattison and Nan-Shan Chang

    Citation: BMC Molecular Biology 2007 8:50

    Content type: Research article

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  4. Previous studies have demonstrated that telomeres in somatic cells are not randomly distributed at the end of the chromosomes. We hypothesize that these chromosome arm specific differences in telomere length (...

    Authors: Jesper Graakjaer, Rikke Christensen, Steen Kolvraa and Nedime Serakinci

    Citation: BMC Molecular Biology 2007 8:49

    Content type: Research article

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  5. Housekeeping genes are commonly used as endogenous reference genes for the relative quantification of target genes in gene expression studies. No conclusive systematic study comparing the suitability of differ...

    Authors: Monika Jung, Azizbek Ramankulov, Jan Roigas, Manfred Johannsen, Martin Ringsdorf, Glen Kristiansen and Klaus Jung

    Citation: BMC Molecular Biology 2007 8:47

    Content type: Research article

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  6. Using a gene clustering strategy we determined intracellular pathway relationships within skeletal myotubes in response to an acute heat stress stimuli. Following heat shock, the transcriptome was analyzed by ...

    Authors: Joseph D Szustakowski, Penelope A Kosinski, Christine A Marrese, Jee-Hyung Lee, Stephen J Elliman, Nanguneri Nirmala and Daniel M Kemp

    Citation: BMC Molecular Biology 2007 8:46

    Content type: Research article

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  7. The genetic code imposes a dilemma for cells. The DNA must be long enough to encode for the complexity of an organism, yet thin and flexible enough to fit within the cell. The combination of these properties g...

    Authors: Richard W Deibler, Jennifer K Mann, De Witt L Sumners and Lynn Zechiedrich

    Citation: BMC Molecular Biology 2007 8:44

    Content type: Research article

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  8. p63 is a transcription factor that plays an important role in skin epidermal development and differentiation. The p63 gene encodes for two major protein isoforms, those containing an amino-terminal trans-activ...

    Authors: Barbara Birkaya, Kori Ortt and Satrajit Sinha

    Citation: BMC Molecular Biology 2007 8:43

    Content type: Research article

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  9. Leptin acts not only on hypothalamic centers to control food intake but has additional functions in peripheral tissues, e.g. inhibition of insulin secretion from pancreatic islets. The leptin receptor (LEPRb) is ...

    Authors: Paul Hekerman, Julia Zeidler, Stefanie Korfmacher, Simone Bamberg-Lemper, Holger Knobelspies, Lennart Zabeau, Jan Tavernier and Walter Becker

    Citation: BMC Molecular Biology 2007 8:41

    Content type: Research article

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  10. The Myc oncoprotein is a transcriptional regulator whose function is essential for normal development. Myc is capable of binding to 10% of the mammalian genome, and it is unclear how a developing embryo contro...

    Authors: Julie M Goodliffe, Michael D Cole and Eric Wieschaus

    Citation: BMC Molecular Biology 2007 8:40

    Content type: Research article

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  11. Methionine sulfoxide reductases (Msrs) are enzymes that catalyze the reduction of oxidized methionine residues. Most organisms that were genetically modified to lack the MsrA gene have shown shortening of their l...

    Authors: Antonella De Luca, Paolo Sacchetta, Marzia Nieddu, Carmine Di Ilio and Bartolo Favaloro

    Citation: BMC Molecular Biology 2007 8:39

    Content type: Research article

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  12. Assessing RNA quality is essential for gene expression analysis, as the inclusion of degraded samples may influence the interpretation of expression levels in relation to biological and/or clinical parameters....

    Authors: Carina Strand, Johan Enell, Ingrid Hedenfalk and Mårten Fernö

    Citation: BMC Molecular Biology 2007 8:38

    Content type: Methodology article

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  13. Previous studies suggest that human RAD9 (hRad9), encoding a DNA damage checkpoint molecule, which is frequently amplified in epithelial tumor cells of breast, lung, head and neck cancer, participates in regulati...

    Authors: Kazuhiro Ishikawa, Hideshi Ishii, Yoshiki Murakumo, Koshi Mimori, Masahiko Kobayashi, Ken-ichi Yamamoto, Masaki Mori, Hiroshi Nishino, Yusuke Furukawa and Keiichi Ichimura

    Citation: BMC Molecular Biology 2007 8:37

    Content type: Research article

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  14. Topoisomerase IIα has been shown to be down-regulated in doxorubicin-resistant cell lines. The specificity proteins Sp1 and Sp3 have been implicated in regulation of topoisomerase IIα transcription, although t...

    Authors: Amram O Williams, Richard J Isaacs and Kathryn M Stowell

    Citation: BMC Molecular Biology 2007 8:36

    Content type: Research article

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  15. In Drosophila melanogaster dosage compensation of most X-linked genes is mediated by the male-specific lethal (MSL) complex, which includes MOF. MOF acetylates histone H4 at lysine 16 (H4K16ac). The X-linked Larv...

    Authors: Vikki M Weake and Maxwell J Scott

    Citation: BMC Molecular Biology 2007 8:35

    Content type: Research article

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  16. The dystroglycan (DG) complex is a major non-integrin cell adhesion system whose multiple biological roles involve, among others, skeletal muscle stability, embryonic development and synapse maturation. DG is ...

    Authors: Ernesto Pavoni, Davide Cacchiarelli, Roberta Tittarelli, Massimiliano Orsini, Antonio Galtieri, Bruno Giardina and Andrea Brancaccio

    Citation: BMC Molecular Biology 2007 8:34

    Content type: Research article

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  17. The main vector for transmission of malaria in India is the Anopheles culicifacies mosquito species, a naturally selected subgroup of which is completely refractory (R) to transmission of the malaria parasite, Pl...

    Authors: Janneth Rodrigues, Neema Agrawal, Anil Sharma, Pawan Malhotra, Tridibes Adak, Virander S Chauhan and Raj K Bhatnagar

    Citation: BMC Molecular Biology 2007 8:33

    Content type: Research article

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  18. the use of specific but partially degenerate primers for nucleic acid hybridisations and PCRs amplification of known or unknown gene families was first reported well over a decade ago and the technique has bee...

    Authors: Zhensheng Pan, Richard Barry, Alexey Lipkin and Mikhail Soloviev

    Citation: BMC Molecular Biology 2007 8:32

    Content type: Research article

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  19. Development in higher eukaryotes involves programmed gene expression. Cell type-specific gene expression is established during this process and is inherited in succeeding cell cycles. Higher eukaryotes have ev...

    Authors: Li Xin, Guo-Ling Zhou, Wei Song, Xue-Song Wu, Gong-Hong Wei, De-Long Hao, Xiang Lv, De-Pei Liu and Chih-Chuan Liang

    Citation: BMC Molecular Biology 2007 8:31

    Content type: Research article

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  20. The ability to regulate transgene expression has many applications, mostly concerning the analysis of gene function. Desirable induction characteristics, such as low un-induced expression, high induced express...

    Authors: Rachel Brough, Antigoni M Papanastasiou and Andrew CG Porter

    Citation: BMC Molecular Biology 2007 8:30

    Content type: Methodology article

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  21. ATM and PARP-1 are two of the most important players in the cell's response to DNA damage. PARP-1 and ATM recognize and bound to both single and double strand DNA breaks in response to different triggers. Here...

    Authors: Rocío Aguilar-Quesada, José Antonio Muñoz-Gámez, David Martín-Oliva, Andreína Peralta, Ma Teresa Valenzuela, Rubén Matínez-Romero, Rosa Quiles-Pérez, Josiane Menissier-de Murcia, Gilbert de Murcia, Mariano Ruiz de Almodóvar and F Javier Oliver

    Citation: BMC Molecular Biology 2007 8:29

    Content type: Research article

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  22. KSRP is a AU-rich element (ARE) binding protein that causes decay of select sets of transcripts in different cell types. We have recently described that phosphatidylinositol 3-kinase/AKT (PI3K-AKT) activation ...

    Authors: Tina Ruggiero, Michele Trabucchi, Marco Ponassi, Giorgio Corte, Ching-Yi Chen, Latifa al-Haj, Khalid SA Khabar, Paola Briata and Roberto Gherzi

    Citation: BMC Molecular Biology 2007 8:28

    Content type: Research article

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  23. Initiation of eukaryotic DNA replication involves many protein-protein and protein-DNA interactions. We have previously shown that 14-3-3 proteins bind cruciform DNA and associate with mammalian and yeast repl...

    Authors: Wafaa Yahyaoui, Mario Callejo, Gerald B Price and Maria Zannis-Hadjopoulos

    Citation: BMC Molecular Biology 2007 8:27

    Content type: Research article

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  24. Giardia intestinalis is a protist found in freshwaters worldwide, and is the most common cause of parasitic diarrhea in humans. The phylogenetic position of this parasite is still much debated. Histones are small...

    Authors: Janet Yee, Anita Tang, Wei-Ling Lau, Heather Ritter, Dewald Delport, Melissa Page, Rodney D Adam, Miklós Müller and Gang Wu

    Citation: BMC Molecular Biology 2007 8:26

    Content type: Research article

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  25. To discover prostate cancer biomarkers, we profiled gene expression in benign and malignant cells laser capture microdissected (LCM) from prostate tissues and metastatic prostatic adenocarcinomas. Here we pres...

    Authors: Dagmar M Kube, Cemile D Savci-Heijink, Anne-Françoise Lamblin, Farhad Kosari, George Vasmatzis, John C Cheville, Donald P Connelly and George G Klee

    Citation: BMC Molecular Biology 2007 8:25

    Content type: Methodology article

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  26. Encephalitozoon cuniculi is a member of a distinctive group of single-celled parasitic eukaryotes called microsporidia, which are closely related to fungi. Some of these organisms, including E. cuniculi, also hav...

    Authors: Erin E Gill and Naomi M Fast

    Citation: BMC Molecular Biology 2007 8:24

    Content type: Research article

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  27. The ubiquitin-proteasome system is the predominant pathway for myofibrillar proteolysis but a previous study in C2C12 myotubes only observed alterations in lysosome-dependent proteolysis in response to complet...

    Authors: Fouzia Sadiq, David G Hazlerigg and Michael A Lomax

    Citation: BMC Molecular Biology 2007 8:23

    Content type: Research article

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  28. We investigated the molecular basis of primary open-angle glaucoma (POAG) using Opticin (OPTC) as a candidate gene on the basis of its expression in the trabecular meshwork cells involved in the disease pathogene...

    Authors: Moulinath Acharya, Suddhasil Mookherjee, Ashima Bhattacharjee, Sanjay KD Thakur, Arun K Bandyopadhyay, Abhijit Sen, Subhabrata Chakrabarti and Kunal Ray

    Citation: BMC Molecular Biology 2007 8:21

    Content type: Research article

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  29. Podoplanin is a membrane mucin that, among a series of tissues, is expressed on late osteoblasts and osteocytes. Since recent findings have focussed on podoplanin's potential role as a tumour progression facto...

    Authors: Brigitte Hantusch, Romana Kalt, Sigurd Krieger, Christina Puri and Dontscho Kerjaschki

    Citation: BMC Molecular Biology 2007 8:20

    Content type: Research article

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  30. The calsarcins comprise a novel family of muscle-specific calcineurin-interaction proteins that play an important role in modulating both the function and substrate specificity of calcineurin in muscle cells. ...

    Authors: Heng Wang, Shulin Yang, E Yang, Zhengmao Zhu, Yulian Mu, Shutang Feng and Kui Li

    Citation: BMC Molecular Biology 2007 8:19

    Content type: Research article

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  31. The genetic basis of telomere length heterogeneity among mammalian species is still not well understood. Recently, a gene named regulator of telomere length elongation helicase (RTEL) was identified and predicted...

    Authors: Zhuo Du, DingSheng Zhao, YongHui Zhao, ShaoHua Wang, Yu Gao and Ning Li

    Citation: BMC Molecular Biology 2007 8:18

    Content type: Research article

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  32. A diverse set of transcripts called 185/333 is strongly expressed in sea urchins responding to immune challenge. Optimal alignments of full-length 185/333 cDNAs requires the insertion of large gaps that define 25...

    Authors: David P Terwilliger, Katherine M Buckley, Virginia Brockton, Nicole J Ritter and L Courtney Smith

    Citation: BMC Molecular Biology 2007 8:16

    Content type: Research article

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  33. In eukaryotic cells, each molecule of H/ACA small nucleolar RNA (snoRNA) assembles with four evolutionarily conserved core proteins to compose a specific ribonucleoprotein particle. One of the four core compon...

    Authors: Sara Riccardo, Giuseppe Tortoriello, Ennio Giordano, Mimmo Turano and Maria Furia

    Citation: BMC Molecular Biology 2007 8:15

    Content type: Research article

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  34. The trophoblast Kunitz domain proteins (TKDPs) constitute a highly expressed, placenta-specific, multigene family restricted to ruminant ungulates and characterized by a C-terminal "Kunitz" domain, preceded by...

    Authors: Anindita Chakrabarty and R Michael Roberts

    Citation: BMC Molecular Biology 2007 8:14

    Content type: Research article

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  35. Chondroprotective agents (CPA) such as glucosamine, curcumin and diacerein represent potential remedies for the management of osteoarthritis and several studies have been performed on their effects in-vitro an...

    Authors: Stefan Toegel, Wenwen Huang, Claudia Piana, Frank M Unger, Michael Wirth, Mary B Goldring, Franz Gabor and Helmut Viernstein

    Citation: BMC Molecular Biology 2007 8:13

    Content type: Research article

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  36. Interleukin 4 (IL-4) has been shown to suppress interleukin-1 (IL-1) induced expression of matrix metalloproteinase-3 (MMP-3) in human synovial and gingival fibroblasts, but the mechanism of suppression has no...

    Authors: Denise Stewart, Masoud Javadi, Mariah Chambers, Chad Gunsolly, Grzegorz Gorski and Ruth C Borghaei

    Citation: BMC Molecular Biology 2007 8:12

    Content type: Research article

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  37. Single-stranded oligonucleotides (ssODN) are used routinely to direct specific base alterations within mammalian genomes that result in the restoration of a functional gene. Despite success with the technique,...

    Authors: Julia U Engstrom and Eric B Kmiec

    Citation: BMC Molecular Biology 2007 8:9

    Content type: Research article

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  38. The enhancer (Eμ3') of the immunoglobulin heavy chain locus (IGH) of the channel catfish (Ictalurus punctatus) has been well characterized. The functional core region consists of two variant Oct transcription fac...

    Authors: Mara L Lennard, Jun-ichi Hikima, David A Ross, Corine P Kruiswijk, Melanie R Wilson, Norman W Miller and Gregory W Warr

    Citation: BMC Molecular Biology 2007 8:8

    Content type: Research article

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  39. Nuclear import of proteins is typically mediated by their physical interaction with soluble cytosolic receptor proteins via a nuclear localization signal (NLS). A simple genetic assay to detect active NLSs bas...

    Authors: Kris S Marshall, Zhiying Zhang, Jennifer Curran, Stephanie Derbyshire and Joe S Mymryk

    Citation: BMC Molecular Biology 2007 8:6

    Content type: Methodology article

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  40. Scavenger receptor type B class I (SR-BI), ABC transporter A1 (ABCA1) -and G1 (ABCG1) all play important roles in the reverse cholesterol transport. Reverse cholesterol transport is a mechanism whereby the bod...

    Authors: Marita Sporstøl, Seyed Ali Mousavi, Winnie Eskild, Norbert Roos and Trond Berg

    Citation: BMC Molecular Biology 2007 8:5

    Content type: Research article

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