Yang A, Kaghad M, Caput D, McKeon F: On the shoulders of giants: p63, p73 and the rise of p53. Trends Genet. 2002, 18: 90-95. 10.1016/S0168-9525(02)02595-7
Article
PubMed
Google Scholar
Barbieri CE, Pietenpol JA: p63 and epithelial biology. Exp Cell Res. 2006, 312: 695-706. 10.1016/j.yexcr.2005.11.028
Article
CAS
PubMed
Google Scholar
Koster MI, Roop DR: Transgenic mouse models provide new insights into the role of p63 in epidermal development. Cell Cycle. 2004, 3: 411-413.
Article
CAS
PubMed
Google Scholar
Yang A, Schweitzer R, Sun D, Kaghad M, Walker N, Bronson RT, Tabin C, Sharpe A, Caput D, Crum C, McKeon F: p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development. Nature. 1999, 398: 714-718. 10.1038/19539
Article
CAS
PubMed
Google Scholar
Mills AA, Zheng B, Wang XJ, Vogel H, Roop DR, Bradley A: p63 is a p53 homologue required for limb and epidermal morphogenesis. Nature. 1999, 398: 708-713. 10.1038/19531
Article
CAS
PubMed
Google Scholar
Yang A, Kaghad M, Wang Y, Gillett E, Fleming MD, Dotsch V, Andrews NC, Caput D, McKeon F: p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. Mol Cell. 1998, 2: 305-316. 10.1016/S1097-2765(00)80275-0
Article
CAS
PubMed
Google Scholar
King KE, Ponnamperuma RM, Yamashita T, Tokino T, Lee LA, Young MF, Weinberg WC: deltaNp63alpha functions as both a positive and a negative transcriptional regulator and blocks in vitro differentiation of murine keratinocytes. Oncogene. 2003, 22: 3635-3644. 10.1038/sj.onc.1206536
Article
CAS
PubMed
Google Scholar
Helton ES, Zhu J, Chen X: The unique NH2-terminally deleted (DeltaN) residues, the PXXP motif, and the PPXY motif are required for the transcriptional activity of the DeltaN variant of p63. J Biol Chem. 2006, 281: 2533-2542. 10.1074/jbc.M507964200
Article
CAS
PubMed
Google Scholar
Westfall MD, Mays DJ, Sniezek JC, Pietenpol JA: The Delta Np63 alpha phosphoprotein binds the p21 and 14-3-3 sigma promoters in vivo and has transcriptional repressor activity that is reduced by Hay-Wells syndrome-derived mutations. Mol Cell Biol. 2003, 23: 2264-2276. 10.1128/MCB.23.7.2264-2276.2003
Article
PubMed Central
CAS
PubMed
Google Scholar
Romano RA, Birkaya B, Sinha S: A Functional Enhancer of Keratin14 Is a Direct Transcriptional Target of DeltaNp63. J Invest Dermatol. 2007, 127: 1175-86. 10.1038/sj.jid.5700652
Article
CAS
PubMed
Google Scholar
Harms K, Nozell S, Chen X: The common and distinct target genes of the p53 family transcription factors. Cell Mol Life Sci. 2004, 61: 822-842. 10.1007/s00018-003-3304-4
Article
CAS
PubMed
Google Scholar
Osada M, Park HL, Nagakawa Y, Yamashita K, Fomenkov A, Kim MS, Wu G, Nomoto S, Trink B, Sidransky D: Differential recognition of response elements determines target gene specificity for p53 and p63. Mol Cell Biol. 2005, 25: 6077-6089. 10.1128/MCB.25.14.6077-6089.2005
Article
PubMed Central
CAS
PubMed
Google Scholar
Ortt K, Sinha S: Derivation of the consensus DNA-binding sequence for p63 reveals unique requirements that are distinct from p53. FEBS Lett. 2006, 580: 4544-4550. 10.1016/j.febslet.2006.07.004
Article
CAS
PubMed
Google Scholar
Barbieri CE, Perez CA, Johnson KN, Ely KA, Billheimer D, Pietenpol JA: IGFBP-3 is a direct target of transcriptional regulation by DeltaNp63alpha in squamous epithelium. Cancer Res. 2005, 65: 2314-2320. 10.1158/0008-5472.CAN-04-3449
Article
CAS
PubMed
Google Scholar
Ihrie RA, Marques MR, Nguyen BT, Horner JS, Papazoglu C, Bronson RT, Mills AA, Attardi LD: Perp is a p63-regulated gene essential for epithelial integrity. Cell. 2005, 120: 843-856. 10.1016/j.cell.2005.01.008
Article
CAS
PubMed
Google Scholar
Kim S, Han J, Kim J, Park C: Maspin expression is transactivated by p63 and is critical for the modulation of lung cancer progression. Cancer Res. 2004, 64: 6900-6905. 10.1158/0008-5472.CAN-04-1657
Article
CAS
PubMed
Google Scholar
Spiesbach K, Tannapfel A, Mossner J, Engeland K: TAp63gamma can substitute for p53 in inducing expression of the maspin tumor suppressor. Int J Cancer. 2005, 114: 555-562. 10.1002/ijc.20766
Article
CAS
PubMed
Google Scholar
Wu G, Nomoto S, Hoque MO, Dracheva T, Osada M, Lee CC, Dong SM, Guo Z, Benoit N, Cohen Y, Rechthand P, Califano J, Moon CS, Ratovitski E, Jen J, Sidransky D, Trink B: DeltaNp63alpha and TAp63alpha regulate transcription of genes with distinct biological functions in cancer and development. Cancer Res. 2003, 63: 2351-2357.
CAS
PubMed
Google Scholar
Sasaki Y, Ishida S, Morimoto I, Yamashita T, Kojima T, Kihara C, Tanaka T, Imai K, Nakamura Y, Tokino T: The p53 family member genes are involved in the Notch signal pathway. J Biol Chem. 2002, 277: 719-724. 10.1074/jbc.M108080200
Article
CAS
PubMed
Google Scholar
Truong AB, Kretz M, Ridky TW, Kimmel R, Khavari PA: p63 regulates proliferation and differentiation of developmentally mature keratinocytes. Genes Dev. 2006, 20: 3185-3197. 10.1101/gad.1463206
Article
PubMed Central
CAS
PubMed
Google Scholar
Romano RA, Birkaya B, Sinha S: Defining the regulatory elements in the proximal promoter of DeltaNp63 in keratinocytes: Potential roles for Sp1/Sp3, NF-Y, and p63. J Invest Dermatol. 2006, 126: 1469-1479. 10.1038/sj.jid.5700297
Article
CAS
PubMed
Google Scholar
Nelson EA, Walker SR, Alvarez JV, Frank DA: Isolation of unique STAT5 targets by chromatin immunoprecipitation-based gene identification. J Biol Chem. 2004, 279: 54724-54730. 10.1074/jbc.M408464200
Article
CAS
PubMed
Google Scholar
Barbieri CE, Tang LJ, Brown KA, Pietenpol JA: Loss of p63 leads to increased cell migration and up-regulation of genes involved in invasion and metastasis. Cancer Res. 2006, 66: 7589-7597. 10.1158/0008-5472.CAN-06-2020
Article
CAS
PubMed
Google Scholar
Vigano MA, Lamartine J, Testoni B, Merico D, Alotto D, Castagnoli C, Robert A, Candi E, Melino G, Gidrol X, Mantovani R: New p63 targets in keratinocytes identified by a genome-wide approach. Embo J. 2006, 25: 5105-5116. 10.1038/sj.emboj.7601375
Article
PubMed Central
CAS
PubMed
Google Scholar
Cawley S, Bekiranov S, Ng HH, Kapranov P, Sekinger EA, Kampa D, Piccolboni A, Sementchenko V, Cheng J, Williams AJ, Wheeler R, Wong B, Drenkow J, Yamanaka M, Patel S, Brubaker S, Tammana H, Helt G, Struhl K, Gingeras TR: Unbiased mapping of transcription factor binding sites along human chromosomes 21 and 22 points to widespread regulation of noncoding RNAs. Cell. 2004, 116: 499-509. 10.1016/S0092-8674(04)00127-8
Article
CAS
PubMed
Google Scholar
Nguyen BC, Lefort K, Mandinova A, Antonini D, Devgan V, Della Gatta G, Koster MI, Zhang Z, Wang J, Tommasi di Vignano A, Kitajewski J, Chiorino G, Roop DR, Missero C, Dotto GP: Cross-regulation between Notch and p63 in keratinocyte commitment to differentiation. Genes Dev. 2006, 20: 1028-1042. 10.1101/gad.1406006
Article
PubMed Central
CAS
PubMed
Google Scholar
Di Marco E, Cutuli N, Guerra L, Cancedda R, De Luca M: Molecular cloning of trkE, a novel trk-related putative tyrosine kinase receptor isolated from normal human keratinocytes and widely expressed by normal human tissues. J Biol Chem. 1993, 268: 24290-24295.
CAS
PubMed
Google Scholar
Vogel W: Discoidin domain receptors: structural relations and functional implications. Faseb J. 1999, 13 Suppl: S77-82.
CAS
PubMed
Google Scholar
Carroll DK, Carroll JS, Leong CO, Cheng F, Brown M, Mills AA, Brugge JS, Ellisen LW: p63 regulates an adhesion programme and cell survival in epithelial cells. Nat Cell Biol. 2006, 8: 551-561. 10.1038/ncb1420
Article
CAS
PubMed
Google Scholar
Testoni B, Borrelli S, Tenedini E, Alotto D, Castagnoli C, Piccolo S, Tagliafico E, Ferrari S, Vigano MA, Mantovani R: Identification of new p63 targets in human keratinocytes. Cell Cycle. 2006, 5: 2805-2811.
Article
CAS
PubMed
Google Scholar
Yang A, Zhu Z, Kapranov P, McKeon F, Church GM, Gingeras TR, Struhl K: Relationships between p63 binding, DNA sequence, transcription activity, and biological function in human cells. Mol Cell. 2006, 24: 593-602. 10.1016/j.molcel.2006.10.018
Article
CAS
PubMed
Google Scholar