Citation Impact
2.57 - 2-year Impact Factor
2.38 - 5-year Impact Factor
0.75 - Source Normalized Impact per Paper (SNIP)
1.28 - SCImago Journal Rank (SJR)
Usage
299,948 Downloads
50 Altmetric Mentions
Page 17 of 17
In mammals, epigenetic information is established and maintained via the postreplicative methylation of cytosine residues by the DNA methyltransferases Dnmt1, Dnmt3a and Dnmt3b. Dnmt1 is required for maintenan...
Citation: BMC Molecular Biology 2003 4:7
The regulation of the immediate-early gene c-fos serves as a paradigm for signal-activated gene induction. Lysophosphatidic acid is a potent serum-borne mitogen able to induce c-fos.
Citation: BMC Molecular Biology 2003 4:6
Double-strand breakage of chromosomal DNA is obviously a serious threat to cells because various activities of the chromosome depend on its integrity. However, recent experiments suggest that such breakage may...
Citation: BMC Molecular Biology 2003 4:5
After intravenous delivery of the adenoviral vector into rats or mice, 95–99% of the encoded protein is produced in the hepatocytes. We observed, as have others, that the early expression levels of the vector ...
Citation: BMC Molecular Biology 2003 4:4
Expansion of an unstable (CGG)n repeat to over 200 triplets within the promoter region of the human FMR1 gene leads to extensive local methylation and transcription silencing, resulting in the loss of FMRP protei...
Citation: BMC Molecular Biology 2003 4:3
Termination of protein synthesis in eukaryotes involves at least two polypeptide release factors (eRFs) – eRF1 and eRF3. The highly conserved translation termination factor eRF1 in Saccharomyces cerevisiae is enc...
Citation: BMC Molecular Biology 2003 4:2
The phage protein pairs, RecE/RecT from Rac or Redα/Redβ from λ, initiate efficient double strand break repair (DSBR) in Escherichia coli that has proven very useful for DNA engineering. These phage pairs initiat...
Citation: BMC Molecular Biology 2003 4:1
Group II introns are mobile genetic elements that form conserved secondary and tertiary structures. In order to determine which of the conserved structural elements are required for mobility, a series of domai...
Citation: BMC Molecular Biology 2002 3:17
NF-κB is implicated in gene regulation involved in neuronal survival, inflammmatory response and cancer. There are relatively few neuronal target genes of NF-κB characterized.
Citation: BMC Molecular Biology 2002 3:16
Secretion of recombinant proteins in yeast can be affected by their improper folding in the endoplasmic reticulum and subsequent elimination of the misfolded molecules via the endoplasmic reticulum associated pro...
Citation: BMC Molecular Biology 2002 3:15
Baculovirus genomes encode a gene called very late expression factor 1 (VLF-1) that is a member of the integrase (Int) family of proteins. In this report we describe the binding properties of purified Autographa ...
Citation: BMC Molecular Biology 2002 3:14
Tetracycline-regulated systems have been used to control the expression of heterologous genes in such diverse organisms as yeast, plants, flies and mice. Adaptation of this prokaryotic regulatory system avoids...
Citation: BMC Molecular Biology 2002 3:13
Electroporation of skeletal muscle after injection of naked DNA was shown by others to increase transgene expression. Information regarding tissue damage caused by electroporation is conflicting. It is also no...
Citation: BMC Molecular Biology 2002 3:12
The tumor suppressor gene PTEN has been found mutated in many types of advanced tumors. When introduced into tumor cells that lack the wild-type allele of the gene, exogenous PTEN was able to suppress their ab...
Citation: BMC Molecular Biology 2002 3:11
Cyclic AMP-dependent protein kinase (PKA) plays a central role in regulation of energy metabolism. Upon stimulation of testicular Sertoli cells by follicle stimulating hormone (FSH), glycolysis is activated to...
Citation: BMC Molecular Biology 2002 3:10
Citation: BMC Molecular Biology 2002 3:9
Specific cis-elements and the associated trans-acting factors have been implicated in the post-transcriptional regulation of gene expression. In the era of genome wide analyses identifying novel trans-acting f...
Citation: BMC Molecular Biology 2002 3:8
The FHIT gene is lost early in the development of many tumors. Fhit possesses intrinsic ApppA hydrolase activity though ApppA cleavage is not required for tumor suppression. Because a mutant form of Fhit that is ...
Citation: BMC Molecular Biology 2002 3:7
cDNA-RDA is one of the subtractive cloning techniques used to isolate differentially expressed genes between two complex cDNA populations. In the present study we present a modification of the protocol describ...
Citation: BMC Molecular Biology 2002 3:6
The rationale of using bovine papillomavirus-1 (BPV-1) derived vectors in gene therapy protocols lies in their episomal maintenance at intermediate to high copy number, and stable, high-level expression of the...
Citation: BMC Molecular Biology 2002 3:5
BCMA (B-cell maturation) belongs to the tumour necrosis factor receptor gene family, and is specifically expressed in mature B lymphocytes. Antisense BCMA RNA is produced by transcription from the same locus a...
Citation: BMC Molecular Biology 2002 3:4
In S. cerevisiae, the mitotic exit network (MEN) proteins, including the Polo-like protein kinase Cdc5 and the protein phosphatase Cdc14, are required for exit from mitosis. In pre-anaphase cells, Cdc14 is seques...
Citation: BMC Molecular Biology 2002 3:3
The proteinase-activated receptor 4 (PAR4) is a G-protein-coupled receptor activated by proteases such as thrombin and trypsin. Although activation of PAR4 has been shown to modulate rat gastrointestinal motil...
Citation: BMC Molecular Biology 2002 3:2
Ribose 2'-O-methylation, the most common nucleotide modification in mammalian rRNA, is directed by the C/D box small nucleolar RNAs (snoRNAs). Thus far, more than fifty putative human rRNA methylation guide snoRN...
Citation: BMC Molecular Biology 2002 3:1
We have used commercially available cDNA arrays to identify EphB4 as a gene that is up-regulated in colon cancer tissue when compared with matched normal tissue from the same patient.
Citation: BMC Molecular Biology 2001 2:15
The sequences encoding the yeast RNA polymerase II (RPB) subunits are single copy genes.
Citation: BMC Molecular Biology 2001 2:14
A study was undertaken to resolve preliminary conflicting results on the proliferation of leukemia cells observed with different c-myc antisense oligonucleotides.
Citation: BMC Molecular Biology 2001 2:13
The cyclin-dependent kinase inhibitor p27Kip1 is essential for proper control of cell cycle progression. The levels of p27Kip1 are regulated by several mechanisms including transcriptional and translational contr...
Citation: BMC Molecular Biology 2001 2:12
Poly purine.pyrimidine sequences have the potential to adopt intramolecular triplex structures and are overrepresented upstream of genes in eukaryotes. These sequences may regulate gene expression by modulatin...
Citation: BMC Molecular Biology 2001 2:11
Transcriptional transactivation is a process with remarkable tolerance for sequence diversity and structural geometry. In studies of the features that constitute transactivating functions, acidity has remained...
Citation: BMC Molecular Biology 2001 2:10
Termination of translation in eukaryotes is controlled by two interacting polypeptide chain release factors, eRFl and eRF3. eRFl recognizes nonsense codons UAA, UAG and UGA, while eRF3 stimulates polypeptide r...
Citation: BMC Molecular Biology 2001 2:9
HIPK2 (homeodomain-interacting protein kinase 2) has been identified as a nuclear serine/threonine kinase. A central function of HIPK2 is repressing transcription of homeodomain containing transcription factors.
Citation: BMC Molecular Biology 2001 2:8
Activation of nuclear factor-κB (NF-κB) is one of the key events in early atherosclerosis and restenosis. We hypothesized that tumor necrosis factor-α (TNF-α) induced and NF-κB mediated expression of intercell...
Citation: BMC Molecular Biology 2001 2:7
The X-ray structure of the MS2 coat protein-operator RNA complex reveals the existence of quasi-synmetric interactions of adenosines -4 and -10 in pockets formed on different subunits of the coat protein dimer...
Citation: BMC Molecular Biology 2001 2:6
CD5 is a pan-T cell surface marker that is also present on a subset of B cells, B-1a cells.Functional and developmental subsets of T cells express characteristic CD5 levels that vary over roughly a 30-fold ran...
Citation: BMC Molecular Biology 2001 2:5
Treatment of mouse F9 embryonal carcinoma cells with all-trans retinoic acid (T-RA) induces differentiation into primitive endodermal type cells. Differentiation requires the action of the receptors for all tr...
Citation: BMC Molecular Biology 2001 2:4
Translation termination is mediated through an interaction between the release factors eRF1 and eRF3 and the stop codon within its nucleotide context. Although it is well known that the nucleotide contexts bot...
Citation: BMC Molecular Biology 2001 2:3
Germline mutations in the tumor suppressor PTEN predispose human beings to breast cancer, and genetic and epigenetic alterations of PTEN are also detected in sporadic human breast cancer. Germline Pten mutations ...
Citation: BMC Molecular Biology 2001 2:2
Some origins in eukaryotic chromosomes fire more frequently than others. In the fission yeast, Schizosaccharomyces pombe, the relative firing frequencies of the three origins clustered 4-8 kbp upstream of the ura...
Citation: BMC Molecular Biology 2001 2:1
PCR amplification of target molecules involves sequence specific primers that flank the region to be amplified. While this technique is generally routine, its applicability may not be sufficient to generate a ...
Citation: BMC Molecular Biology 2000 1:2
Proteins HMG1 and HMG2 are two of the most abundant non histone proteins in the nucleus of mammalian cells, and contain a domain of homology with many proteins implicated in the control of development, such as...
Citation: BMC Molecular Biology 2000 1:1
Citation Impact
2.57 - 2-year Impact Factor
2.38 - 5-year Impact Factor
0.75 - Source Normalized Impact per Paper (SNIP)
1.28 - SCImago Journal Rank (SJR)
Usage
299,948 Downloads
50 Altmetric Mentions