Skip to main content

Advertisement

Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Articles

Page 5 of 17

  1. Glial cell line-derived neurotrophic factor (GDNF) is a potent survival factor for many cell types, and its expression is widespread both within and outside of the nervous system. The regulation of GDNF expres...

    Authors: Kentaro Oh-hashi, Yoko Hirata and Kazutoshi Kiuchi

    Citation: BMC Molecular Biology 2012 13:2

    Content type: Research article

    Published on:

  2. SPO11 is a key protein for promoting meiotic recombination, by generating chromatin locus- and timing-specific DNA double-strand breaks (DSBs). The DSB activity of SPO11 was shown by genetic analyses, but whet...

    Authors: Yoshinori Shingu, Takeshi Tokai, Yasuo Agawa, Kentaro Toyota, Selina Ahmed, Makiko Kawagishi-Kobayashi, Akira Komatsu, Tsutomu Mikawa, Masa-Toshi Yamamoto, Kyo Wakasa, Takehiko Shibata and Kohji Kusano

    Citation: BMC Molecular Biology 2012 13:1

    Content type: Research article

    Published on:

  3. The brown planthopper (BPH), Nilaparvata lugens, is the most devastating rice pest in many areas throughout Asia. The reproductive system of female N. lugens consists of a pair of ovaries with 24-33 ovarioles per...

    Authors: Xiaolin Dong, Yifan Zhai, Jianqing Zhang, Zhongxiang Sun, Jing Chen, Jie Chen and Wenqing Zhang

    Citation: BMC Molecular Biology 2011 12:53

    Content type: Research article

    Published on:

  4. DLK2 is an EGF-like membrane protein, closely related to DLK1, which is involved in adipogenesis. Both proteins interact with the NOTCH1 receptor and are able to modulate its activation. The expression of the ...

    Authors: Samuel Rivero, Almudena Ruiz-García, María JM Díaz-Guerra, Jorge Laborda and José J García-Ramírez

    Citation: BMC Molecular Biology 2011 12:52

    Content type: Research article

    Published on:

  5. The S. cerevisiae MAPKKK Ste11p, a homologue of mammalian MEKK1, regulates three MAPK cascades for mating, invasive growth and osmotic stress and provides functions that are additive with the cell wall integrity ...

    Authors: Xiaoyan Wang, Mark A Sheff, David M Simpson and Elaine A Elion

    Citation: BMC Molecular Biology 2011 12:51

    Content type: Research article

    Published on:

  6. All sequenced genomes of representatives of the Francisella genus contain two rpoA genes, which encode non-identical RNA polymerase (RNAP) subunits, α1 and α2. In all other bacteria studied to date, a dimer of id...

    Authors: Damir Mukhamedyarov, Kira S Makarova, Konstantin Severinov and Konstantin Kuznedelov

    Citation: BMC Molecular Biology 2011 12:50

    Content type: Research article

    Published on:

  7. The processes that compose expression of a given gene are far more complex than previously thought presenting unprecedented conceptual and mechanistic challenges that require development of new tools. Chromati...

    Authors: Jingjing Yu, Qinghua Feng, Yusong Ruan, Radko Komers, Nancy Kiviat and Karol Bomsztyk

    Citation: BMC Molecular Biology 2011 12:49

    Content type: Methodology article

    Published on:

  8. Staufen2 (Stau2), a double-stranded RNA-binding protein, is a component of neuronal RNA granules, which are dendritic mRNA transport machines. Although Stau2 is thought to be involved in the dendritic targetin...

    Authors: Takashi Miki, Yasunao Kamikawa, Sadamu Kurono, Yuka Kaneko, Jun Katahira and Yoshihiro Yoneda

    Citation: BMC Molecular Biology 2011 12:48

    Content type: Research article

    Published on:

  9. Defensins are a well known family of cationic antibacterial peptides (AMPs) isolated from fungi, plants, insects, mussels, birds, and various mammals. They are predominantly active against gram (+) bacteria, a...

    Authors: AlaaEddeen M Seufi, Elsayed E Hafez and Fatma H Galal

    Citation: BMC Molecular Biology 2011 12:47

    Content type: Research article

    Published on:

  10. The SWI/SNF chromatin remodeling factors have the ability to remodel nucleosomes and play essential roles in key developmental processes. SWI/SNF complexes contain one subunit with ATPase activity, which in Droso...

    Authors: Johan Waldholm, Zhi Wang, David Brodin, Anu Tyagi, Simei Yu, Ulrich Theopold, Ann Kristin Östlund Farrants and Neus Visa

    Citation: BMC Molecular Biology 2011 12:46

    Content type: Research article

    Published on:

  11. The first telomerase-associated protein (Est1) was isolated in yeast due to its essential role in telomere maintenance. The human counterparts EST1A, EST1B, and EST1C perform diverse functions in nonsense-medi...

    Authors: David CF Sealey, Aleksandar D Kostic, Catherine LeBel, Fiona Pryde and Lea Harrington

    Citation: BMC Molecular Biology 2011 12:45

    Content type: Research article

    Published on:

  12. CD164 (also known as MGC-24v or endolyn) is a sialomucin which has been suggested to participate in regulating the proliferation, cell adhesion and differentiation of hematopoietic stem and progenitor cells. C...

    Authors: Jingqun Tang, Zhaohui Luo, Guangqian Zhou, Chao Song, Fenglei Yu, Juanjuan Xiang and Gang Li

    Citation: BMC Molecular Biology 2011 12:44

    Content type: Research article

    Published on:

  13. DNA polymerase III, the main enzyme responsible for bacterial DNA replication, is composed of three sub-assemblies: the polymerase core, the β-sliding clamp, and the clamp loader. During replication, single-st...

    Authors: Sirine El Houry Mignan, Gregor Witte, Natalie Naue and Ute Curth

    Citation: BMC Molecular Biology 2011 12:43

    Content type: Research article

    Published on:

  14. The halophilic archaeon Halobacterium salinarum expresses bacteriorhodopsin, a retinal-protein that allows photosynthetic growth. Transcription of the bop (b acterioop sin) gene is controlled by two transcription...

    Authors: Valery Tarasov, Rita Schwaiger, Katarina Furtwängler, Mike Dyall-Smith and Dieter Oesterhelt

    Citation: BMC Molecular Biology 2011 12:42

    Content type: Research article

    Published on:

  15. It is known that retinoid receptor function is attenuated during T cell activation, a phenomenon that involves actin remodeling, suggesting that actin modification may play a role in such inhibition. Here we h...

    Authors: Mohammad Ishaq, Bor-Ruei Lin, Marjorie Bosche, Xin Zheng, Jun Yang, Dawei Huang, Richard A Lempicki and Ven Natarajan

    Citation: BMC Molecular Biology 2011 12:41

    Content type: Research article

    Published on:

    The Erratum to this article has been published in BMC Molecular Biology 2012 13:14

  16. In response to infection, viral genomes are processed by Dicer-like (DCL) ribonuclease proteins into viral small RNAs (vsRNAs) of discrete sizes. vsRNAs are then used as guides for silencing the viral genome. ...

    Authors: Tatiane F Silva, Elisson AC Romanel, Roberto RS Andrade, Laurent Farinelli, Magne Østerås, Cécile Deluen, Régis L Corrêa, Carlos EG Schrago and Maite FS Vaslin

    Citation: BMC Molecular Biology 2011 12:40

    Content type: Research article

    Published on:

  17. The vomeronasal organ (VNO) detects pheromones via two large families of vomeronasal receptors: vomeronasal receptor 1 (V1R) and vomeronasal receptor 2 (V2R). Both VRs have a common receptor activation cascade...

    Authors: Stephen Frankenberg, Nanette Y Schneider, Terrence P Fletcher, Geoffrey Shaw and Marilyn B Renfree

    Citation: BMC Molecular Biology 2011 12:39

    Content type: Research article

    Published on:

  18. Polyhexamethylene biguanide (PHMB) is an antiseptic polymer that is mainly used for cleaning hospitals and pools and combating Acantamoeba infection. Its fungicide activity was recently shown by its lethal effect...

    Authors: Carolina Elsztein, Rodrigo M de Lucena and Marcos A de Morais Jr

    Citation: BMC Molecular Biology 2011 12:38

    Content type: Research article

    Published on:

  19. The RNA binding protein, DEAD END (DND1), is essential for maintaining viable germ cells in vertebrates. It is also a testicular germ cell tumor susceptibility factor in mice. DND1 has been shown to interact w...

    Authors: Rui Zhu, Michelina Iacovino, Elisabeth Mahen, Michael Kyba and Angabin Matin

    Citation: BMC Molecular Biology 2011 12:37

    Content type: Research article

    Published on:

  20. Reference genes with stable expression are required to normalize expression differences of target genes in qPCR experiments. Several procedures and companion software have been proposed to find the most stable...

    Authors: Magdalena Serrano, Natalia Moreno-Sánchez, Carmen González, Ane Marcos-Carcavilla, Mario Van Poucke, Jorge H Calvo, Judit Salces, Jaime Cubero and María J Carabaño

    Citation: BMC Molecular Biology 2011 12:36

    Content type: Research article

    Published on:

  21. Expressed short hairpin RNAs (shRNA) used in mammalian RNA interference (RNAi) are often designed around a specific short interfering RNA (siRNA) core. Whilst there are algorithms to aid siRNA design, hairpin-...

    Authors: Glen J Mcintyre, Yi-Hsin Yu, Mehnaaz Lomas and Gregory C Fanning

    Citation: BMC Molecular Biology 2011 12:34

    Content type: Research article

    Published on:

  22. DNA cruciforms play an important role in the regulation of natural processes involving DNA. These structures are formed by inverted repeats, and their stability is enhanced by DNA supercoiling. Cruciform struc...

    Authors: Václav Brázda, Rob C Laister, Eva B Jagelská and Cheryl Arrowsmith

    Citation: BMC Molecular Biology 2011 12:33

    Content type: Review

    Published on:

  23. Core promoters are cis-regulatory modules to which bind the basal transcriptional machinery and which participate in the regulation of transcription initiation. Although core promoters have not been extensively i...

    Authors: Adriana C Garcia, Daniel LG Gitaí, Fernanda C Humann, Maria L Paçó-Larson and Nadia Monesi

    Citation: BMC Molecular Biology 2011 12:32

    Content type: Research article

    Published on:

  24. Improving the treatment of renal cell carcinoma (RCC) will depend on the development of better biomarkers for predicting disease progression and aiding the design of appropriate therapies. One such marker may ...

    Authors: Naohisa Takaoka, Tatsuya Takayama, Takumi Teratani, Takayuki Sugiyama, Soichi Mugiya and Seiichiro Ozono

    Citation: BMC Molecular Biology 2011 12:31

    Content type: Research article

    Published on:

  25. Transient Receptor Potential Canonical 1 (TRPC1) is a widely-expressed mammalian cationic channel with functional effects that include stimulation of cardiovascular remodelling. The initial aim of this study w...

    Authors: Alexandra M Dedman, Yasser Majeed, Sarka Tumova, Fanning Zeng, Bhaskar Kumar, Christopher Munsch, Alan N Bateson, Jürgen Wittmann, Hans-Martin Jäck, Karen E Porter and David J Beech

    Citation: BMC Molecular Biology 2011 12:30

    Content type: Research article

    Published on:

  26. CGGBP1 is a CGG-triplet repeat binding protein, which affects transcription from CGG-triplet-rich promoters such as the FMR1 gene and the ribosomal RNA gene clusters. Earlier, we reported some previously unkno...

    Authors: Umashankar Singh, Pernilla Roswall, Lene Uhrbom and Bengt Westermark

    Citation: BMC Molecular Biology 2011 12:28

    Content type: Research article

    Published on:

  27. During functional studies on the rat stress-inducible Hspa1b (hsp70.1) gene we noticed that some liposome-based DNA carriers, which are used for transfection, induce its promoter activity. This observation concer...

    Authors: Anna Fiszer-Kierzkowska, Natalia Vydra, Aleksandra Wysocka-Wycisk, Zuzana Kronekova, Michał Jarząb, Katarzyna Marta Lisowska and Zdzisław Krawczyk

    Citation: BMC Molecular Biology 2011 12:27

    Content type: Research article

    Published on:

  28. The NCI-60 is a collection of tumor cell lines derived from a variety of human adult cancer tissue types and is commonly used for genetic analysis and screening of potential chemotherapeutic agents. We wanted ...

    Authors: Dawn M Stults, Michael W Killen, Brent J Shelton and Andrew J Pierce

    Citation: BMC Molecular Biology 2011 12:23

    Content type: Research article

    Published on:

  29. Muscleblind-like 1 (MBNL1) is an alternative splicing factor containing four CCCH Zinc fingers (ZnFs). The sequestration of MBNL1 by expanded CUG and CCUG repeats is a major component in causing myotonic dystr...

    Authors: Danielle Cass, Rachel Hotchko, Paul Barber, Kimberly Jones, Devika P Gates and J Andrew Berglund

    Citation: BMC Molecular Biology 2011 12:20

    Content type: Research article

    Published on:

  30. Accurate interpretation of quantitative PCR (qPCR) data requires normalization using constitutively expressed reference genes. Ribosomal RNA is often used as a reference gene for transcriptional studies in E. col...

    Authors: Kang Zhou, Lihan Zhou, Qing 'En Lim, Ruiyang Zou, Gregory Stephanopoulos and Heng-Phon Too

    Citation: BMC Molecular Biology 2011 12:18

    Content type: Research article

    Published on:

  31. Escherichia coli RecA plays a crucial role in recombinational processes, the induction of SOS responses and mutagenic lesion bypasses. It has also been demonstrated that RecA protein is indispensable when it come...

    Authors: Marta Wanarska, Beata Krawczyk, Piotr Hildebrandt and Józef Kur

    Citation: BMC Molecular Biology 2011 12:17

    Content type: Research article

    Published on:

  32. Numerous microRNAs (miRNAs) have heterogeneous ends resulting from imprecise cleavages by processing nucleases and from various non-templated nucleotide additions. The scale of miRNA end-heterogeneity is best ...

    Authors: Edyta Koscianska, Julia Starega-Roslan, Lukasz J Sznajder, Marta Olejniczak, Paulina Galka-Marciniak and Wlodzimierz J Krzyzosiak

    Citation: BMC Molecular Biology 2011 12:14

    Content type: Methodology article

    Published on:

  33. The stability of reference genes has a tremendous effect on the results of relative quantification of genes expression by quantitative polymerase chain reaction. Equine Inflammatory Airway Disease (IAD) is a c...

    Authors: Laura Beekman, Triin Tohver, Rkia Dardari and Renaud Léguillette

    Citation: BMC Molecular Biology 2011 12:5

    Content type: Research article

    Published on:

  34. The Rasd1 protein is a dexamethasone induced monomeric Ras-like G protein that oscillates in the suprachiasmatic nucleus (SCN). Previous studies have shown that Rasd1 modulates multiple signaling cascades. How...

    Authors: Jen Jen Tan, Shufen Angeline Ong and Ken-Shiung Chen

    Citation: BMC Molecular Biology 2011 12:4

    Content type: Research article

    Published on:

  35. With lower manufacturing cost, high spot density, and flexible probe design, genomic tiling microarrays are ideal for comprehensive transcriptome studies. Typically, transcriptome profiling using microarrays i...

    Authors: Wen-Han Yu, Hedda Høvik, Ingar Olsen and Tsute Chen

    Citation: BMC Molecular Biology 2011 12:3

    Content type: Methodology article

    Published on:

  36. Brown algae of the genus Ectocarpus exhibit high levels of genetic diversity and variability in morphological and physiological characteristics. With the establishment of E. siliculosus as a model and the availab...

    Authors: Simon M Dittami, Caroline Proux, Sylvie Rousvoal, Akira F Peters, J Mark Cock, Jean-Yves Coppée, Catherine Boyen and Thierry Tonon

    Citation: BMC Molecular Biology 2011 12:2

    Content type: Methodology article

    Published on:

  37. TEAD1 (TEA domain family member 1) is constitutively expressed in cardiac and skeletal muscles. It acts as a key molecule of muscle development, and trans-activates multiple target genes involved in cell prolifer...

    Authors: Haifang Qiu, Fengli Wang, Chuxin Liu, Xuewen Xu and Bang Liu

    Citation: BMC Molecular Biology 2011 12:1

    Content type: Research article

    Published on:

  38. The synchrony of an organism with both its external and internal environment is critical to well-being and survival. As a result, organisms display daily cycles of physiology and behavior termed circadian rhyt...

    Authors: Kallur S Naidu, Louis W Morgan and Michael J Bailey

    Citation: BMC Molecular Biology 2010 11:104

    Content type: Research article

    Published on:

  39. The importance of appropriate normalization controls in quantitative real-time polymerase chain reaction (qPCR) experiments has become more apparent as the number of biological studies using this methodology h...

    Authors: Meesbah Jiwaji, Rónán Daly, Kshama Pansare, Pauline McLean, Jingli Yang, Walter Kolch and Andrew R Pitt

    Citation: BMC Molecular Biology 2010 11:103

    Content type: Methodology article

    Published on:

  40. The ubiquitous family of DnaN sliding processivity clamp proteins plays essential roles in DNA replication, DNA repair, and cell cycle progression, in part by managing the actions of the different proteins inv...

    Authors: Mark D Sutton, Jill M Duzen and Sarah K Scouten Ponticelli

    Citation: BMC Molecular Biology 2010 11:102

    Content type: Research article

    Published on:

  41. The CTCF insulator protein is a highly conserved zinc finger protein that has been implicated in many aspects of gene regulation and nuclear organization. The protein has been hypothesized to organize the huma...

    Authors: Melissa J MacPherson and Paul D Sadowski

    Citation: BMC Molecular Biology 2010 11:101

    Content type: Research article

    Published on:

  42. Gastrointestinal stromal tumors (GIST) represent the most common mesenchymal tumors of the gastrointestinal tract. About 85% carry an activating mutation in the KIT or PDGFRA gene. Approximately 10% of GIST are s...

    Authors: Jana Fassunke, Marie-Christine Blum, Hans-Ulrich Schildhaus, Marc Zapatka, Benedikt Brors, Helen Künstlinger, Reinhard Büttner, Eva Wardelmann and Sabine Merkelbach-Bruse

    Citation: BMC Molecular Biology 2010 11:100

    Content type: Research article

    Published on:

  43. Postgenomic transcriptome analyses have identified large numbers of noncoding (nc)RNAs in mammalian cells. However, the biological function of long ncRNAs in mammalian cells remains largely unknown. Our recent...

    Authors: Kazuma Aoki, Akira Harashima, Miho Sano, Takahide Yokoi, Shuji Nakamura, Masayoshi Kibata and Tetsuro Hirose

    Citation: BMC Molecular Biology 2010 11:99

    Content type: Research article

    Published on:

  44. Members of the Sox gene family isolated from both vertebrates and invertebrates have been proved to participate in a wide variety of developmental processes, including sex determination and differentiation. Am...

    Authors: Fei Han, Zhijian Wang, Fengrui Wu, Zhihao Liu, Baofeng Huang and Deshou Wang

    Citation: BMC Molecular Biology 2010 11:98

    Content type: Research article

    Published on:

  45. Despite extensive efforts devoted to predicting protein-coding genes in genome sequences, many bona fide genes have not been found and many existing gene models are not accurate in all sequenced eukaryote genomes...

    Authors: Matthew J Nesbitt, Donald G Moerman and Nansheng Chen

    Citation: BMC Molecular Biology 2010 11:96

    Content type: Research article

    Published on:

  46. Neurotrophins and their receptors are key molecules in the regulation of neuronal differentiation and survival. They mediate the survival of neurons during development and adulthood and are implicated in synap...

    Authors: Monica Guidi, Margarita Muiños-Gimeno, Birgit Kagerbauer, Eulàlia Martí, Xavier Estivill and Yolanda Espinosa-Parrilla

    Citation: BMC Molecular Biology 2010 11:95

    Content type: Research article

    Published on: