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  1. In mammals, epigenetic information is established and maintained via the postreplicative methylation of cytosine residues by the DNA methyltransferases Dnmt1, Dnmt3a and Dnmt3b. Dnmt1 is required for maintenan...

    Authors: Jean B Margot, Ann E Ehrenhofer-Murray and Heinrich Leonhardt

    Citation: BMC Molecular Biology 2003 4:7

    Content type: Research article

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  2. The regulation of the immediate-early gene c-fos serves as a paradigm for signal-activated gene induction. Lysophosphatidic acid is a potent serum-borne mitogen able to induce c-fos.

    Authors: Sebastian Schuck, Ana Soloaga, Gerhard Schratt, J Simon C Arthur and Alfred Nordheim

    Citation: BMC Molecular Biology 2003 4:6

    Content type: Research article

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  3. After intravenous delivery of the adenoviral vector into rats or mice, 95–99% of the encoded protein is produced in the hepatocytes. We observed, as have others, that the early expression levels of the vector ...

    Authors: Pierre Lefesvre, Joline Attema, Angelique Lemckert, Menzo Havenga and Dirk van Bekkum

    Citation: BMC Molecular Biology 2003 4:4

    Content type: Research article

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  4. Expansion of an unstable (CGG)n repeat to over 200 triplets within the promoter region of the human FMR1 gene leads to extensive local methylation and transcription silencing, resulting in the loss of FMRP protei...

    Authors: Simon P Chandler, Pushpa Kansagra and Mark C Hirst

    Citation: BMC Molecular Biology 2003 4:3

    Content type: Research article

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  5. Termination of protein synthesis in eukaryotes involves at least two polypeptide release factors (eRFs) – eRF1 and eRF3. The highly conserved translation termination factor eRF1 in Saccharomyces cerevisiae is enc...

    Authors: Svetlana E Moskalenko, Svetlana V Chabelskaya, Sergei G Inge-Vechtomov, Michel Philippe and Galina A Zhouravleva

    Citation: BMC Molecular Biology 2003 4:2

    Content type: Research article

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  6. The phage protein pairs, RecE/RecT from Rac or Redα/Redβ from λ, initiate efficient double strand break repair (DSBR) in Escherichia coli that has proven very useful for DNA engineering. These phage pairs initiat...

    Authors: Youming Zhang, Joep PP Muyrers, Jeanette Rientjes and A Francis Stewart

    Citation: BMC Molecular Biology 2003 4:1

    Content type: Research article

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  7. NF-κB is implicated in gene regulation involved in neuronal survival, inflammmatory response and cancer. There are relatively few neuronal target genes of NF-κB characterized.

    Authors: Barbara Kaltschmidt, Ralf A Linker, Jinbo Deng and Christian Kaltschmidt

    Citation: BMC Molecular Biology 2002 3:16

    Content type: Research article

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  8. Secretion of recombinant proteins in yeast can be affected by their improper folding in the endoplasmic reticulum and subsequent elimination of the misfolded molecules via the endoplasmic reticulum associated pro...

    Authors: Michael O Agaphonov, Nina V Romanova, Polina M Trushkina, Vladimir N Smirnov and Michael D Ter-Avanesyan

    Citation: BMC Molecular Biology 2002 3:15

    Content type: Research article

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  9. Tetracycline-regulated systems have been used to control the expression of heterologous genes in such diverse organisms as yeast, plants, flies and mice. Adaptation of this prokaryotic regulatory system avoids...

    Authors: Paraic A Kenny, Tariq Enver and Alan Ashworth

    Citation: BMC Molecular Biology 2002 3:13

    Content type: Methodology article

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  10. The tumor suppressor gene PTEN has been found mutated in many types of advanced tumors. When introduced into tumor cells that lack the wild-type allele of the gene, exogenous PTEN was able to suppress their ab...

    Authors: Ray-Chang Wu, Martina Blumenthal, Xinwei Li and Axel H Schönthal

    Citation: BMC Molecular Biology 2002 3:11

    Content type: Research article

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  11. Cyclic AMP-dependent protein kinase (PKA) plays a central role in regulation of energy metabolism. Upon stimulation of testicular Sertoli cells by follicle stimulating hormone (FSH), glycolysis is activated to...

    Authors: Maria Krudtaa Dahle, Kjetil Taskén and Kristin Austlid Taskén

    Citation: BMC Molecular Biology 2002 3:10

    Content type: Research article

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  12. The FHIT gene is lost early in the development of many tumors. Fhit possesses intrinsic ApppA hydrolase activity though ApppA cleavage is not required for tumor suppression. Because a mutant form of Fhit that is ...

    Authors: Marta Rubio-Texeira, James M Varnum, Pawel Bieganowski and Charles Brenner

    Citation: BMC Molecular Biology 2002 3:7

    Content type: Research article

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  13. cDNA-RDA is one of the subtractive cloning techniques used to isolate differentially expressed genes between two complex cDNA populations. In the present study we present a modification of the protocol describ...

    Authors: Anelia A Kuvbachieva and Andre M Goffinet

    Citation: BMC Molecular Biology 2002 3:6

    Content type: Methodology article

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  14. The rationale of using bovine papillomavirus-1 (BPV-1) derived vectors in gene therapy protocols lies in their episomal maintenance at intermediate to high copy number, and stable, high-level expression of the...

    Authors: Jaana Tammur, Hiljar Sibul, Ene Ustav, Mart Ustav and Andres Metspalu

    Citation: BMC Molecular Biology 2002 3:5

    Content type: Research article

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  15. BCMA (B-cell maturation) belongs to the tumour necrosis factor receptor gene family, and is specifically expressed in mature B lymphocytes. Antisense BCMA RNA is produced by transcription from the same locus a...

    Authors: Anastassia Hatzoglou, Frédérique Deshayes, Christine Madry, Geneviéve Laprée, Elias Castanas and Andreas Tsapis

    Citation: BMC Molecular Biology 2002 3:4

    Content type: Research article

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  16. In S. cerevisiae, the mitotic exit network (MEN) proteins, including the Polo-like protein kinase Cdc5 and the protein phosphatase Cdc14, are required for exit from mitosis. In pre-anaphase cells, Cdc14 is seques...

    Authors: Wenying Shou, Ramzi Azzam, Susan L Chen, Michael J Huddleston, Christopher Baskerville, Harry Charbonneau, Roland S Annan, Steve A Carr and Raymond J Deshaies

    Citation: BMC Molecular Biology 2002 3:3

    Content type: Research article

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  17. The proteinase-activated receptor 4 (PAR4) is a G-protein-coupled receptor activated by proteases such as thrombin and trypsin. Although activation of PAR4 has been shown to modulate rat gastrointestinal motil...

    Authors: Willemijntje A Hoogerwerf, Helen Lee Hellmich, Maria Adelaide Micci, John H Winston, Lei Zou and Pankaj J Pasricha

    Citation: BMC Molecular Biology 2002 3:2

    Content type: Research article

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  18. We have used commercially available cDNA arrays to identify EphB4 as a gene that is up-regulated in colon cancer tissue when compared with matched normal tissue from the same patient.

    Authors: Sally-Anne Stephenson, Stefan Slomka, Evelyn L Douglas, Peter J Hewett and Jennifer E Hardingham

    Citation: BMC Molecular Biology 2001 2:15

    Content type: Research article

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  19. The cyclin-dependent kinase inhibitor p27Kip1 is essential for proper control of cell cycle progression. The levels of p27Kip1 are regulated by several mechanisms including transcriptional and translational contr...

    Authors: Jennifer Coleman, Michelle Hawkinson, Robin Miskimins and W Keith Miskimins

    Citation: BMC Molecular Biology 2001 2:12

    Content type: Research article

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  20. Poly purine.pyrimidine sequences have the potential to adopt intramolecular triplex structures and are overrepresented upstream of genes in eukaryotes. These sequences may regulate gene expression by modulatin...

    Authors: Amit K Maiti and Samir K Brahmachari

    Citation: BMC Molecular Biology 2001 2:11

    Content type: Research article

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  21. Transcriptional transactivation is a process with remarkable tolerance for sequence diversity and structural geometry. In studies of the features that constitute transactivating functions, acidity has remained...

    Authors: Majid Abedi, Giordano Caponigro, Jiaxiang Shen, Steven Hansen, Tanya Sandrock and Alexander Kamb

    Citation: BMC Molecular Biology 2001 2:10

    Content type: Research article

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  22. Termination of translation in eukaryotes is controlled by two interacting polypeptide chain release factors, eRFl and eRF3. eRFl recognizes nonsense codons UAA, UAG and UGA, while eRF3 stimulates polypeptide r...

    Authors: Valery N Urakov, Igor A Valouev, Eugeny I Lewitin, Sergey V Paushkin, Vyacheslav S Kosorukov, Vitaly V Kushnirov, Vladimir N Smirnov and Michael D Ter-Avanesyan

    Citation: BMC Molecular Biology 2001 2:9

    Content type: Research article

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  23. HIPK2 (homeodomain-interacting protein kinase 2) has been identified as a nuclear serine/threonine kinase. A central function of HIPK2 is repressing transcription of homeodomain containing transcription factors.

    Authors: Ying Wang, Klaus-Michael Debatin and Hubert Hug

    Citation: BMC Molecular Biology 2001 2:8

    Content type: Research article

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  24. Activation of nuclear factor-κB (NF-κB) is one of the key events in early atherosclerosis and restenosis. We hypothesized that tumor necrosis factor-α (TNF-α) induced and NF-κB mediated expression of intercell...

    Authors: Rainer Voisard, Nicola Huber, Regine Baur, Milorat Susa, Oliver Ickrath, Anton Both, Wolfgang Koenig and Vinzenz Hombach

    Citation: BMC Molecular Biology 2001 2:7

    Content type: Research article

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  25. CD5 is a pan-T cell surface marker that is also present on a subset of B cells, B-1a cells.Functional and developmental subsets of T cells express characteristic CD5 levels that vary over roughly a 30-fold ran...

    Authors: James W Tung, Shaun S Kunnavatana, Leonard A Herzenberg and Leonore A Herzenberg

    Citation: BMC Molecular Biology 2001 2:5

    Content type: Research article

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  26. Treatment of mouse F9 embryonal carcinoma cells with all-trans retinoic acid (T-RA) induces differentiation into primitive endodermal type cells. Differentiation requires the action of the receptors for all tr...

    Authors: Lucia Perletti, Eliezer Kopf, Lucie Carré and Irwin Davidson

    Citation: BMC Molecular Biology 2001 2:4

    Content type: Research article

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  27. Translation termination is mediated through an interaction between the release factors eRF1 and eRF3 and the stop codon within its nucleotide context. Although it is well known that the nucleotide contexts bot...

    Authors: Michel Cassan and Jean-Pierre Rousset

    Citation: BMC Molecular Biology 2001 2:3

    Content type: Research article

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  28. Germline mutations in the tumor suppressor PTEN predispose human beings to breast cancer, and genetic and epigenetic alterations of PTEN are also detected in sporadic human breast cancer. Germline Pten mutations ...

    Authors: Yi Li, Katrina Podsypanina, Xiufan Liu, Allison Crane, Lee K Tan, Ramon Parsons and Harold E Varmus

    Citation: BMC Molecular Biology 2001 2:2

    Content type: Research article

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  29. PCR amplification of target molecules involves sequence specific primers that flank the region to be amplified. While this technique is generally routine, its applicability may not be sufficient to generate a ...

    Authors: Yongxin Wang, Joseph M Fugaro, Fauzia Siddiq, Chandra Mouli V Goparaju, Fulvio Lonardo, Anil Wali, John F Lechner and Harvey I Pass

    Citation: BMC Molecular Biology 2000 1:2

    Content type: Methodology article

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