Skip to main content

Advertisement

Articles

Page 7 of 17

  1. Circadian rhythms have a profound effect on human health. Their disruption can lead to serious pathologies, such as cancer and obesity. Gene expression studies in these pathologies are often studied in differe...

    Authors: Rok Kosir, Jure Acimovic, Marko Golicnik, Martina Perse, Gregor Majdic, Martina Fink and Damjana Rozman

    Citation: BMC Molecular Biology 2010 11:60

    Content type: Research article

    Published on:

  2. Several genes have been used as housekeeping genes and choosing an appropriate reference gene is important for accurate quantitative RNA expression in real time RT-PCR technique. The expression levels of refer...

    Authors: Azalina Zainuddin, Kien Hui Chua, Norhazira Abdul Rahim and Suzana Makpol

    Citation: BMC Molecular Biology 2010 11:59

    Content type: Research article

    Published on:

  3. Poor reproductive maturation of the black tiger shrimp (Penaeus monodon) in captivity is one of the serious threats to sustainability of the shrimp farming industry. Understanding molecular mechanisms governing r...

    Authors: Thidathip Wongsurawat, Rungnapa Leelatanawit, Natechanok Thamniemdee, Umaporn Uawisetwathana, Nitsara Karoonuthaisiri, Piamsak Menasveta and Sirawut Klinbunga

    Citation: BMC Molecular Biology 2010 11:55

    Content type: Research article

    Published on:

  4. In eukaryotes the transcription initiation by RNA polymerase II requires numerous general and regulatory factors including general transcription factors. The general transcription factor TFIIF controls the act...

    Authors: Sabrina Heisel, Nunja C Habel, Nicole Schuetz, Alessia Ruggieri and Eckart Meese

    Citation: BMC Molecular Biology 2010 11:53

    Content type: Research article

    Published on:

  5. Several chronic conditions leading to skeletal muscle dysfunction are known to be associated with changes in the expression of myosin heavy chain (MHC) isoforms at both the mRNA and protein level. Many of thes...

    Authors: Daniel P Tonge, Simon W Jones, Ronald G Bardsley and Tim Parr

    Citation: BMC Molecular Biology 2010 11:52

    Content type: Methodology article

    Published on:

  6. Activin receptor-like kinase 1 (ALK1) is a Transforming Growth Factor-β (TGF-β) receptor type I, mainly expressed in endothelial cells that plays a pivotal role in vascular remodelling and angiogenesis. Mutati...

    Authors: Eva M Garrido-Martin, Francisco J Blanco, Africa Fernandez-L, Carmen Langa, Calvin P Vary, Ursula E Lee, Scott L Friedman, Luisa M Botella and Carmelo Bernabeu

    Citation: BMC Molecular Biology 2010 11:51

    Content type: Research article

    Published on:

  7. The planktonic microcrustacean Daphnia pulex is among the best-studied animals in ecological, toxicological and evolutionary research. One aspect that has sustained interest in the study system is the ability of

    Authors: Katina I Spanier, Florian Leese, Christoph Mayer, John K Colbourne, Don Gilbert, Michael E Pfrender and Ralph Tollrian

    Citation: BMC Molecular Biology 2010 11:50

    Content type: Research article

    Published on:

  8. Histone deacetylase inhibitors have been proposed as potential enhancers of the cytotoxic effect of cisplatin and other anticancer drugs. Their application would permit the use of lower therapeutic doses and r...

    Authors: Miglena Koprinarova, Petya Markovska, Ivan Iliev, Boyka Anachkova and George Russev

    Citation: BMC Molecular Biology 2010 11:49

    Content type: Research article

    Published on:

  9. STAR/GSG proteins regulate gene expression in metazoans by binding consensus sites in the 5' or 3' UTRs of target mRNA transcripts. Owing to the high degree of homology across the STAR domain, most STAR protei...

    Authors: Andrew B Carmel, Joann Wu, Katrina A Lehmann-Blount and James R Williamson

    Citation: BMC Molecular Biology 2010 11:48

    Content type: Research article

    Published on:

  10. Normalization of gene expression data refers to the comparison of expression values using reference standards that are consistent across all conditions of an experiment. In PCR studies, genes designated as "ho...

    Authors: Nigel C Noriega, Steven G Kohama and Henryk F Urbanski

    Citation: BMC Molecular Biology 2010 11:47

    Content type: Methodology article

    Published on:

  11. Transcription cofactors related to Drosophila Schnurri facilitate the transcriptional programs regulated by BMP signaling in C. elegans, Drosophila, Xenopus, and mouse. In different systems, Schnurri homologs hav...

    Authors: Jianghua Yin, Ling Yu and Cathy Savage-Dunn

    Citation: BMC Molecular Biology 2010 11:46

    Content type: Research article

    Published on:

  12. The Enabled/Vasodilator stimulated phosphoprotein (Ena/VASP) gene family comprises three genes in vertebrates: Vasp, Enabled homologue (Enah) and Ena-VASP like (Evl). Enah has the most complex gene structure. It ...

    Authors: Sylvie Veniere, Davy Waterschoot, Joël Vandekerckhove, Anja Lambrechts and Christophe Ampe

    Citation: BMC Molecular Biology 2010 11:45

    Content type: Research article

    Published on:

  13. microRNAs (miRNAs) are small single-stranded non-coding RNAs that act as crucial regulators of gene expression. Different methods have been developed for miRNA expression profiling in order to better understan...

    Authors: Alberto Biscontin, Silvia Casara, Stefano Cagnin, Lucia Tombolan, Angelo Rosolen, Gerolamo Lanfranchi and Cristiano De Pittà

    Citation: BMC Molecular Biology 2010 11:44

    Content type: Methodology article

    Published on:

  14. The human DHRS4 gene cluster consists of three genes, DHRS4, DHRS4L2 and DHRS4L1. Among them, DHRS4 encodes NADP(H)-dependent retinol dehydrogenase/reductase. In a previous study, we investigated the alternative ...

    Authors: Zhong-Jing Su, Qiao-Xia Zhang, Ge-Fei Liu, Xu-Hong Song, Qi Li, Rui-Jian Wang, Hai-Bin Chen, Xiao-Yuan Xu, Xu-Xia Sui and Dong-Yang Huang

    Citation: BMC Molecular Biology 2010 11:43

    Content type: Research article

    Published on:

  15. pIREShyg2 has been widely used as a bicistronic expression vector. However, it is not known if the vector would affect the expression of cloned genes via nonsense-mediated mRNA decay (NMD), an mRNA surveillanc...

    Authors: Yayoi Shikama, Huiyuan Hu, Makiko Ohno, Isao Matsuoka, Tsutomu Shichishima and Junko Kimura

    Citation: BMC Molecular Biology 2010 11:42

    Content type: Methodology article

    Published on:

  16. Archaea combine bacterial-as well as eukaryotic-like features to regulate cellular processes. Halobacterium salinarum R1 encodes eight leucine-responsive regulatory protein (Lrp)-homologues. The function of two o...

    Authors: Rita Schwaiger, Christoph Schwarz, Katarina Furtwängler, Valery Tarasov, Andy Wende and Dieter Oesterhelt

    Citation: BMC Molecular Biology 2010 11:40

    Content type: Research article

    Published on:

  17. Given the epidemic proportions of obesity worldwide and the concurrent prevalence of metabolic syndrome, there is an urgent need for better understanding the underlying mechanisms of metabolic syndrome, in par...

    Authors: Rohini Mehta, Aybike Birerdinc, Noreen Hossain, Arian Afendy, Vikas Chandhoke, Zobair Younossi and Ancha Baranova

    Citation: BMC Molecular Biology 2010 11:39

    Content type: Research article

    Published on:

  18. The Eight-Twenty-One (ETO) nuclear co-repressor gene belongs to the ETO homologue family also containing Myeloid Translocation Gene on chromosome 16 (MTG16) and myeloid translocation Gene-Related protein 1 (MTGR1...

    Authors: Ram Ajore, Rakesh Singh Dhanda, Urban Gullberg and Inge Olsson

    Citation: BMC Molecular Biology 2010 11:38

    Content type: Research article

    Published on:

  19. The transforming growth factor-β (TGF-β) family constitutes of dimeric proteins that regulate the growth, differentiation and metabolism of many cell types, including that of skeletal muscle in mammals. The po...

    Authors: Bruria Funkenstein, Elena Olekh and Sonia B Jakowlew

    Citation: BMC Molecular Biology 2010 11:37

    Content type: Research article

    Published on:

  20. Real time RT-PCR has become an important tool for analyzing gene expression in fish. Although several housekeeping genes have been evaluated in Atlantic halibut (Hippoglossus Hippoglossus L.), appropriate referen...

    Authors: Aina-Cathrine Øvergård, Audun Helge Nerland and Sonal Patel

    Citation: BMC Molecular Biology 2010 11:36

    Content type: Research article

    Published on:

  21. Formation of site specific genomic double strand breaks (DSBs), induced by the expression of a pair of engineered zinc-finger nucleases (ZFNs), dramatically increases the rates of homologous recombination (HR)...

    Authors: Petter A Olsen, Monika Gelazauskaite, Markus Randøl and Stefan Krauss

    Citation: BMC Molecular Biology 2010 11:35

    Content type: Research article

    Published on:

  22. The Y chromosome of mammals is particularly prone to accumulate genes related to male fertility. However, the high rate of molecular evolution on this chromosome predicts reduced power to the across-species co...

    Authors: Alexandra M Lopes, Ricardo N Miguel, Carole A Sargent, Peter J Ellis, António Amorim and Nabeel A Affara

    Citation: BMC Molecular Biology 2010 11:33

    Content type: Research article

    Published on:

  23. Alternative splicing is one of the key mechanisms that generate biological diversity. Even though alternative splicing also occurs in the 5' and 3' untranslated regions (UTRs) of mRNAs, the understanding of th...

    Authors: Ramesh Palaniswamy, Stephan Teglund, Matthias Lauth, Peter G Zaphiropoulos and Takashi Shimokawa

    Citation: BMC Molecular Biology 2010 11:32

    Content type: Research article

    Published on:

  24. Topors is a nuclear protein that co-localizes with promyelocytic leukemia bodies and has both ubiquitin and SUMO E3 ligase activity. Expression studies implicated Topors as a tumor suppressor in various malign...

    Authors: Henderson Marshall, Mantu Bhaumik, Hana Aviv, Dirk Moore, Ming Yao, Jayeeta Dutta, Hussein Rahim, Murugesan Gounder, Shridar Ganesan, Ahamed Saleem and Eric Rubin

    Citation: BMC Molecular Biology 2010 11:31

    Content type: Research article

    Published on:

  25. MicroRNAs (miRNAs), a family of small non-coding RNA molecules, appear to regulate animal lipid metabolism and preadipocyte conversion to form lipid-assimilating adipocytes (i.e. adipogenesis). However, no miRNA ...

    Authors: Weiwu Jin, Michael V Dodson, Stephen S Moore, John A Basarab and Le Luo Guan

    Citation: BMC Molecular Biology 2010 11:29

    Content type: Research article

    Published on:

  26. Strict regulation of caste differentiation, at the molecular level, is thought to be important to maintain social structure in insect societies. Previously, a number of extrinsic and intrinsic factors have bee...

    Authors: Matthew R Tarver, Xuguo Zhou and Michael E Scharf

    Citation: BMC Molecular Biology 2010 11:28

    Content type: Research article

    Published on:

  27. Elasmobranch fishes are an ancient group of vertebrates which have high potential as model species for research into evolutionary physiology and genomics. However, no comparative studies have established suita...

    Authors: Kalle T Rytkönen, Gillian MC Renshaw, Kevin J Ashton, Grant Williams-Pritchard, Erica H Leder and Mikko Nikinmaa

    Citation: BMC Molecular Biology 2010 11:27

    Content type: Research article

    Published on:

  28. Selection of appropriate endogenous control is a critical step in gene expression analysis. The aim of this study was to evaluate expression stability of four frequently used endogenous controls: β-actin, glyc...

    Authors: Jelena Brkljačić, Nikola Tanić, Danijela Vojnović Milutinović, Ivana Elaković, Sanja Manitašević Jovanović, Tatjana Perišić, Jadranka Dundjerski and Gordana Matić

    Citation: BMC Molecular Biology 2010 11:26

    Content type: Methodology article

    Published on:

  29. Carbonic anhydrases (CAs) are found in many organisms, in which they contribute to several important biological processes. The vertebrate α-CA family consists of 16 subfamilies, three of which (VIII, X and XI)...

    Authors: Ashok Aspatwar, Martti EE Tolvanen and Seppo Parkkila

    Citation: BMC Molecular Biology 2010 11:25

    Content type: Research article

    Published on:

  30. The Red-headed krait (Bungarus flaviceps, Squamata: Serpentes: Elapidae) is a medically important venomous snake that inhabits South-East Asia. Although the venoms of most species of the snake genus Bungarus have...

    Authors: Ang Swee Siang, Robin Doley, Freek J Vonk and R Manjunatha Kini

    Citation: BMC Molecular Biology 2010 11:24

    Content type: Research article

    Published on:

  31. Hexamerins are hemocyanin-derived proteins that have lost the ability to bind copper ions and transport oxygen; instead, they became storage proteins. The current study aimed to broaden our knowledge on the he...

    Authors: Juliana R Martins, Francis MF Nunes, Alexandre S Cristino, Zilá LP Simões and Márcia MG Bitondi

    Citation: BMC Molecular Biology 2010 11:23

    Content type: Research article

    Published on:

  32. Quantitative real-time RT-PCR (RT-qPCR) is a highly sensitive method for mRNA quantification, but requires invariant expression of the chosen reference gene(s). In pathological myocardium, there is limited inf...

    Authors: Trond Brattelid, Lisbeth H Winer, Finn Olav Levy, Knut Liestøl, Ole M Sejersted and Kristin B Andersson

    Citation: BMC Molecular Biology 2010 11:22

    Content type: Research article

    Published on:

  33. Differentiation of F9 embryonal carcinoma (EC) cells into parietal endoderm (PE) provides a tractable model system for studying molecular events during early and inaccessible stages of murine development. PE f...

    Authors: Dimitris Athineos, Lynne Marshall and Robert J White

    Citation: BMC Molecular Biology 2010 11:21

    Content type: Research article

    Published on:

  34. We have previously demonstrated that the POU transcription factor CEH-6 is required for driving aqp-8 expression in the C. elegans excretory (canal) cell, an osmotic regulatory organ that is functionally analogou...

    Authors: Allan K Mah, Domena K Tu, Robert C Johnsen, Jeffrey S Chu, Nansheng Chen and David L Baillie

    Citation: BMC Molecular Biology 2010 11:19

    Content type: Research article

    Published on:

  35. When DNA double-strand breaks (DSB) are induced by ionizing radiation (IR) in cells, histone H2AX is quickly phosphorylated into γ-H2AX (p-S139) around the DSB site. The necessity of DNA-PKcs in regulating the...

    Authors: Jing An, Yue-Cheng Huang, Qing-Zhi Xu, Li-Jun Zhou, Zeng-Fu Shang, Bo Huang, Yu Wang, Xiao-Dan Liu, De-Chang Wu and Ping-Kun Zhou

    Citation: BMC Molecular Biology 2010 11:18

    Content type: Research article

    Published on:

  36. The bacterial Lsm protein, Hfq, is an RNA chaperone involved in many reactions related to RNA metabolism, such as replication and stability, control of small RNA activity and polyadenylation. Despite this wide...

    Authors: Jacques Le Derout, Irina V Boni, Philippe Régnier and Eliane Hajnsdorf

    Citation: BMC Molecular Biology 2010 11:17

    Content type: Research article

    Published on:

  37. It has been observed that following viroid infection, there is an accumulation of viroid-derived siRNAs in infected plants. Some experimental results suggest that these small RNAs may be produced by the plant ...

    Authors: François Bolduc, Christopher Hoareau, Patrick St-Pierre and Jean-Pierre Perreault

    Citation: BMC Molecular Biology 2010 11:16

    Content type: Research article

    Published on:

  38. Quantitative real-time reverse transcriptase polymerase chain reaction (qRT-PCR) is a sensitive technique for quantifying gene expression levels. One or more appropriate reference genes must be selected to acc...

    Authors: Asad Maroufi, Erik Van Bockstaele and Marc De Loose

    Citation: BMC Molecular Biology 2010 11:15

    Content type: Research article

    Published on:

  39. MCPIP is a novel CCCH zinc finger protein described as an RNase engaged in the regulation of immune responses. The regulation of expression of the gene coding for MCPIP - ZC3H12A is poorly explored.

    Authors: Aneta Kasza, Paulina Wyrzykowska, Irena Horwacik, Piotr Tymoszuk, Danuta Mizgalska, Karren Palmer, Hanna Rokita, Andrew D Sharrocks and Jolanta Jura

    Citation: BMC Molecular Biology 2010 11:14

    Content type: Research article

    Published on:

  40. Lymphoid Enhancer Factor-1 (Lef-1) is a member of a transcription factor family that acts as downstream mediator of the Wnt/β-catenin signalling pathway which plays a critical role in osteoblast proliferation ...

    Authors: Elisabetta Lambertini, Tiziana Franceschetti, Elena Torreggiani, Letizia Penolazzi, Antonio Pastore, Stefano Pelucchi, Roberto Gambari and Roberta Piva

    Citation: BMC Molecular Biology 2010 11:13

    Content type: Research article

    Published on:

  41. Gene expression analysis has many applications in cancer diagnosis, prognosis and therapeutic care. Relative quantification is the most widely adopted approach whereby quantification of gene expression is norm...

    Authors: Elrasheid AH Kheirelseid, Kah Hoong Chang, John Newell, Michael J Kerin and Nicola Miller

    Citation: BMC Molecular Biology 2010 11:12

    Content type: Research article

    Published on:

  42. There has long been evidence supporting the idea that RNR and the dNTP-synthesizing complex must be closely linked to the replication complex or replisome. We contributed to this body of evidence in proposing ...

    Authors: M Antonia Sánchez-Romero, Felipe Molina and Alfonso Jiménez-Sánchez

    Citation: BMC Molecular Biology 2010 11:11

    Content type: Research article

    Published on: