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  1. Content type: Research article

    Oxidative stress can induce cell injury in vascular endothelial cells, which is the initial event in the development of atherosclerosis. Although quantitative real-time polymerase chain reaction (qRT-PCR) has ...

    Authors: Tianyi Li, Hongying Diao, Lei Zhao, Yue Xing, Jichang Zhang, Ning Liu, Youyou Yan, Xin Tian, Wei Sun and Bin Liu

    Citation: BMC Molecular Biology 2017 18:10

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  2. Content type: Research article

    SPI1 is an essential transcription factor (TF) for the hematopoietic lineage, in which its expression is tightly controlled through a −17-kb upstream regulatory region and a promoter region. Both regulatory re...

    Authors: Shubham Goyal, Takahiro Suzuki, Jing-Ru Li, Shiori Maeda, Mami Kishima, Hajime Nishimura, Yuri Shimizu and Harukazu Suzuki

    Citation: BMC Molecular Biology 2017 18:9

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    The Erratum to this article has been published in BMC Molecular Biology 2017 18:11

  3. Content type: Research article

    Immunoglobulins (Igs) are fundamental components of the adaptive immune system of vertebrates, with the IgT/IgZ isotype specific of Teleosts. In this paper we describe the identification of an IgT heavy chain ...

    Authors: Francesco Buonocore, Valentina Stocchi, Noelia Nunez-Ortiz, Elisa Randelli, Marco Gerdol, Alberto Pallavicini, Angelo Facchiano, Chiara Bernini, Laura Guerra, Giuseppe Scapigliati and Simona Picchietti

    Citation: BMC Molecular Biology 2017 18:8

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  4. Content type: Methodology article

    It has been pointed out that environmental factors or chemicals can cause diseases that are developmental in origin. To detect abnormal epigenetic alterations in DNA methylation, convenient and cost-effective ...

    Authors: Toshiki Aiba, Toshiyuki Saito, Akiko Hayashi, Shinji Sato, Harunobu Yunokawa, Toru Maruyama, Wataru Fujibuchi, Hisaka Kurita, Chiharu Tohyama and Seiichiroh Ohsako

    Citation: BMC Molecular Biology 2017 18:7

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  5. Content type: Research article

    STAT1 and IRF1 collaborate to induce interferon-γ (IFNγ) stimulated genes (ISGs), but the extent to which they act alone or together is unclear. The effect of single nucleotide polymorphisms (SNPs) on in vivo ...

    Authors: Mohamed Abou El Hassan, Katherine Huang, Manoja B. K. Eswara, Zhaodong Xu, Tao Yu, Arthur Aubry, Zuyao Ni, Izzy Livne-bar, Monika Sangwan, Mohamad Ahmad and Rod Bremner

    Citation: BMC Molecular Biology 2017 18:6

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  6. Content type: Research article

    MicroRNAs (miRNAs) are a group of short non-coding RNAs involved in the inhibition of protein translation or in mRNA degradation. Although the regulatory roles of miRNAs in various biological processes have be...

    Authors: Kang-Sheng Ma, Fen Li, Ying Liu, Ping-Zhuo Liang, Xue-Wei Chen and Xi-Wu Gao

    Citation: BMC Molecular Biology 2017 18:5

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  7. Content type: Research article

    Pheromone binding proteins (PBPs) of male Lepidoptera function in chemical communication, mate attraction and recognition. Directional selection was previously predicted between PBP3 orthologs of Ostrinia furnaca...

    Authors: Tiantao Zhang, Yaqi Sun, Kevin W. Wanner, Brad S. Coates, Kanglai He and Zhenying Wang

    Citation: BMC Molecular Biology 2017 18:4

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  8. Content type: Research article

    Farnesyl pyrophosphate synthase (FPS) belongs to the short-chain prenyltransferase family, and it performs a conserved and essential role in the terpenoid biosynthesis pathway. However, its classification, evo...

    Authors: Jieying Qian, Yong Liu, Naixia Chao, Chengtong Ma, Qicong Chen, Jian Sun and Yaosheng Wu

    Citation: BMC Molecular Biology 2017 18:3

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  9. Content type: Research article

    The mammalian sperm-associated antigen 16 gene (Spag16) uses alternative promoters to produce two major transcript isoforms (Spag16L and Spag16S) and encode proteins that are involved in the cilia/flagella format...

    Authors: Ling Zhang, Yunhao Liu, Wei Li, Qiaoling Zhang, Yanwei Li, Junpin Liu, Jie Min, Chaofan Shuang, Shizheng Song and Zhibing Zhang

    Citation: BMC Molecular Biology 2017 18:2

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  10. Content type: Research article

    DNA methylation is a major epigenetic modification, playing a crucial role in the development and differentiation of higher organisms. DNA methylation is also known to regulate transcription by gene repression...

    Authors: Puja Sinha, Kiran Singh and Manisha Sachan

    Citation: BMC Molecular Biology 2017 18:1

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  11. Content type: Research article

    Single-stranded DNA-binding proteins are essential cellular components required for the protection, metabolism and processing of single-stranded DNA. Human single-stranded DNA-binding protein 1 (hSSB1) is one ...

    Authors: Nicholas W. Ashton, Dorothy Loo, Nicolas Paquet, Kenneth J. O’Byrne and Derek J. Richard

    Citation: BMC Molecular Biology 2016 17:24

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  12. Content type: Methodology article

    Chromosome conformation capture (3C) is a powerful and widely used technique for detecting the physical interactions between chromatin regions in vivo. The principle of 3C is to convert physical chromatin inte...

    Authors: Meijun Du and Liang Wang

    Citation: BMC Molecular Biology 2016 17:23

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  13. Content type: Research article

    Ataxia telangiectasia mutated (ATM) and TRRAP proteins belong to the phosphatidylinositol 3-kinase-related kinase family and are involved in DNA damage repair and chromatin remodeling. ATM is a checkpoint kina...

    Authors: Rebecca J. Smith, Matthew S. Savoian, Lauren E. Weber and Jeong Hyeon Park

    Citation: BMC Molecular Biology 2016 17:22

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  14. Content type: Research article

    Eukaryotic translation initiation factor 4E (eIF4E) plays a pivotal role in the control of cap-dependent translation initiation, modulates the fate of specific mRNAs, occurs in processing bodies (PBs) and is r...

    Authors: Klara Frydryskova, Tomas Masek, Katerina Borcin, Silvia Mrvova, Veronica Venturi and Martin Pospisek

    Citation: BMC Molecular Biology 2016 17:21

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  15. Content type: Review

    Nucleophosmin (NPM1) is a critical cellular protein that has been implicated in a number of pathways including mRNA transport, chromatin remodeling, apoptosis and genome stability. NPM1 function is a critical ...

    Authors: Joseph K. Box, Nicolas Paquet, Mark N. Adams, Didier Boucher, Emma Bolderson, Kenneth J. O’Byrne and Derek J. Richard

    Citation: BMC Molecular Biology 2016 17:19

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  16. Content type: Research article

    Serine–arginine rich splicing factor 2 (SRSF2) is a protein known for its role in RNA splicing and genome stability. It has been recently discovered that SRSF2, along with other splicing regulators, is frequen...

    Authors: Lindsey Skrdlant, Jeremy M. Stark and Ren-Jang Lin

    Citation: BMC Molecular Biology 2016 17:18

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  17. Content type: Research article

    Stearoyl-CoA desaturase 1 (SCD1) desaturates long chain fatty acids and is therefore a key enzyme in fat catabolism. Its synthesis is downregulated in liver during illnesses caused by high levels of circulatin...

    Authors: Tianle Xu, Xiangzhen Shen and Hans-Martin Seyfert

    Citation: BMC Molecular Biology 2016 17:16

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  18. Content type: Research Article

    In contrast to rat and mouse databases, the NCBI gene database lists the human dual-endothelin1/VEGFsp receptor (DEspR, formerly Dear) as a unitary transcribed pseudogene due to a stop [TGA]-codon at codon#14 in ...

    Authors: Victoria L. M. Herrera, Martin Steffen, Ann Marie Moran, Glaiza A. Tan, Khristine A. Pasion, Keith Rivera, Darryl J. Pappin and Nelson Ruiz-Opazo

    Citation: BMC Molecular Biology 2016 17:15

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  19. Content type: Research article

    The breast and ovarian cancer susceptibility gene BRCA1 encodes a multifunctional tumor suppressor protein BRCA1, which is involved in regulating cellular processes such as cell cycle, transcription, DNA repair, ...

    Authors: Václav Brázda, Lucia Hároníková, Jack C. C. Liao, Helena Fridrichová and Eva B. Jagelská

    Citation: BMC Molecular Biology 2016 17:14

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  20. Content type: Research article

    Cells respond to DNA damage by activating the phosphatidylinositol-3 kinase-related kinases, p53 and other pathways to promote cell cycle arrest, apoptosis, and/or DNA repair. Here we report that protein palmi...

    Authors: Na Cao, Jia-Kai Li, Yu-Qing Rao, Huijuan Liu, Ji Wu, Baojie Li, Peiquan Zhao, Li Zeng and Jing Li

    Citation: BMC Molecular Biology 2016 17:12

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  21. Content type: Research article

    Non-coding RNAs have gained increasing attention during the last decade. The first large group of non-coding RNAs to be characterized systematically starting at the beginning of the 21st century were small oli...

    Authors: Malte P. Bartram, Elena Amendola, Thomas Benzing, Bernhard Schermer, Gabriella de Vita and Roman-Ulrich Müller

    Citation: BMC Molecular Biology 2016 17:11

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  22. Content type: Methodology article

    Targeted genomic editing using the CRISPR/Cas9 methodology has opened exciting new avenues in probing gene function in virtually any model system, including cultured mammalian cells. Depending on the desired m...

    Authors: Jason A. Estep, Erin L. Sternburg, Gissell A. Sanchez and Fedor V. Karginov

    Citation: BMC Molecular Biology 2016 17:9

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  23. Content type: Research article

    Bothrops colombiensis is a highly dangerous pit viper and responsible for over 70 % of snakebites in Venezuela. Although the composition in B. colombiensis venom has been identified us...

    Authors: Montamas Suntravat, Néstor L. Uzcategui, Chairat Atphaisit, Thomas J. Helmke, Sara E. Lucena, Elda E. Sánchez and A. Rodríguez Acosta

    Citation: BMC Molecular Biology 2016 17:7

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    The Erratum to this article has been published in BMC Molecular Biology 2016 17:13

  24. Content type: Research article

    Breast cancer is the most frequent malignancy in women and drug resistance is the major obstacle for its successful chemotherapy. In the present study, we analyzed the involvement of an oncofetal gene, sal-lik...

    Authors: Yuan-Yuan Chen, Zhi-Zhen Li, Yuan-Yuan Ye, Feng Xu, Rui-Jie Niu, Hong-Chen Zhang, Yi-Jian Zhang, Ying-Bin Liu and Bao-San Han

    Citation: BMC Molecular Biology 2016 17:6

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  25. Content type: Reviewer acknowledgement

    The editors of BMC Molecular Biology would like to thank all our reviewers who have contributed to the journal in Volume 16 (2015).

    Authors: Timothy R. Sands

    Citation: BMC Molecular Biology 2016 17:5

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  26. Content type: Research article

    The genes coding for Y RNAs are evolutionarily conserved in vertebrates. These non-coding RNAs are essential for the initiation of chromosomal DNA replication in vertebrate cells. However thus far, no informat...

    Authors: Quirino Alves de Lima Neto, Francisco Ferreira Duarte Junior, Paulo Sérgio Alves Bueno, Flavio Augusto Vicente Seixas, Madzia Pauline Kowalski, Eyemen Kheir, Torsten Krude and Maria Aparecida Fernandez

    Citation: BMC Molecular Biology 2016 17:1

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  27. Content type: Research article

    Androgens play an important role for the development of male fertility and gained interest as growth and survival factors for certain types of cancer. Androgens act via the androgen receptor (AR/Ar), which is inv...

    Authors: D. Fietz, M. Markmann, D. Lang, L. Konrad, J. Geyer, S. Kliesch, T. Chakraborty, H. Hossain and M. Bergmann

    Citation: BMC Molecular Biology 2015 16:23

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  28. Content type: Research article

    Small non-coding RNAs (sncRNAs) are a class of transcripts implicated in several eukaryotic regulatory mechanisms, namely gene silencing and chromatin regulation. Despite significant progress in their identifi...

    Authors: Ana Raquel Soares, Noémia Fernandes, Marisa Reverendo, Hugo Rafael Araújo, José Luís Oliveira, Gabriela M. R. Moura and Manuel A. S. Santos

    Citation: BMC Molecular Biology 2015 16:22

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  29. Content type: Research article

    Gene expression is an inherently stochastic process, owing to its dynamic molecular nature. Protein amount distributions, which can be acquired by cytometry using a reporter gene, can inform about the mechanis...

    Authors: Ophélie Arnaud, Sam Meyer, Elodie Vallin, Guillaume Beslon and Olivier Gandrillon

    Citation: BMC Molecular Biology 2015 16:20

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    The Erratum to this article has been published in BMC Molecular Biology 2016 17:2

  30. Content type: Research article

    Nuclear receptor family member, Estrogen related receptor β, and the Hedgehog signal transduction pathway are both reported to relate to tumorigenesis and induced pluripotent stem cell reprogramming. We hypoth...

    Authors: Yuan Lu, Jilong Li, Jianlin Cheng and Dennis B. Lubahn

    Citation: BMC Molecular Biology 2015 16:19

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  31. Content type: Research article

    Studies of DNA damage response are critical for the comprehensive understanding of age-related changes in cells, tissues and organisms. Syrian hamster cells halt proliferation and become presenescent after sev...

    Authors: Ljudmila Solovjeva, Denis Firsanov, Anastasia Vasilishina, Vadim Chagin, Nadezhda Pleskach, Andrey Kropotov and Maria Svetlova

    Citation: BMC Molecular Biology 2015 16:18

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  32. Content type: Research article

    mRNA binding proteins (RBPs) constitute 10–15 % of the eukaryotic proteome and play important part in post-transcriptional regulation of gene expression. Due to the instability of RNA and the transient nature ...

    Authors: Nitzan Samra, Avigail Atir-Lande, Lilach Pnueli and Yoav Arava

    Citation: BMC Molecular Biology 2015 16:17

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  33. Content type: Research article

    ALL1-fused from chromosome 1q (AF1q), originally considered as an oncogenic factor, has been implicated in neuronal development; however, its upstream regulatory mechanisms in neural system remained elusive.

    Authors: Yuanyuan Hu, Qianwen Sun, Chen Zhang, Qingquan Sha and Xiulian Sun

    Citation: BMC Molecular Biology 2015 16:15

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  34. Content type: Review

    TRIM28 is a multidomain protein with versatile functions in transcription and DNA repair. Recently it was shown that this factor plays unanticipated roles in transcriptional elongation. TRIM28 was shown to sta...

    Authors: Heeyoun Bunch and Stuart K Calderwood

    Citation: BMC Molecular Biology 2015 16:14

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  35. Content type: Research article

    In gene expression analysis, overlapping genes, splice variants, and fusion transcripts are potential sources of data analysis artefacts, depending on how the observed intensity is assigned to one, or more gen...

    Authors: Rasmus Wernersson, Thomas Frogne, Claude Rescan, Lena Hansson, Christine Bruun, Mads Grønborg, Jan Nygaard Jensen and Ole Dragsbæk Madsen

    Citation: BMC Molecular Biology 2015 16:13

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  36. Content type: Research article

    SIRT6, a member of the NAD+-dependent histone/protein deacetylase family, regulates genomic stability, metabolism, and lifespan. MYH glycosylase and APE1 are two base excision repair (BER) enzymes involved in mut...

    Authors: Bor-Jang Hwang, Jin Jin, Ying Gao, Guoli Shi, Amrita Madabushi, Austin Yan, Xin Guan, Michal Zalzman, Satoshi Nakajima, Li Lan and A-Lien Lu

    Citation: BMC Molecular Biology 2015 16:12

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  37. Content type: Research article

    MicroRNAs, small non-encoding RNAs that post-transcriptionally modulate expression of their target genes, have been implicated as critical regulatory molecules in endothelial cells.

    Authors: Wei-Long Jiang, Yu-Feng Zhang, Qing-Qing Xia, Jian Zhu, Xin Yu, Tao Fan and Feng Wang

    Citation: BMC Molecular Biology 2015 16:11

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  38. Content type: Reviewer acknowledgement

    The editors of BMC Molecular Biology would like to thank all our reviewers who have contributed to the journal in Volume 15 (2014).

    Authors: Tim Sands

    Citation: BMC Molecular Biology 2015 16:10

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