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  1. Content type: Research article

    Stearoyl-CoA desaturase 1 (SCD1) desaturates long chain fatty acids and is therefore a key enzyme in fat catabolism. Its synthesis is downregulated in liver during illnesses caused by high levels of circulatin...

    Authors: Tianle Xu, Xiangzhen Shen and Hans-Martin Seyfert

    Citation: BMC Molecular Biology 2016 17:16

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  2. Content type: Research Article

    In contrast to rat and mouse databases, the NCBI gene database lists the human dual-endothelin1/VEGFsp receptor (DEspR, formerly Dear) as a unitary transcribed pseudogene due to a stop [TGA]-codon at codon#14 in ...

    Authors: Victoria L. M. Herrera, Martin Steffen, Ann Marie Moran, Glaiza A. Tan, Khristine A. Pasion, Keith Rivera, Darryl J. Pappin and Nelson Ruiz-Opazo

    Citation: BMC Molecular Biology 2016 17:15

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  3. Content type: Research article

    The breast and ovarian cancer susceptibility gene BRCA1 encodes a multifunctional tumor suppressor protein BRCA1, which is involved in regulating cellular processes such as cell cycle, transcription, DNA repair, ...

    Authors: Václav Brázda, Lucia Hároníková, Jack C. C. Liao, Helena Fridrichová and Eva B. Jagelská

    Citation: BMC Molecular Biology 2016 17:14

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  4. Content type: Research article

    Cells respond to DNA damage by activating the phosphatidylinositol-3 kinase-related kinases, p53 and other pathways to promote cell cycle arrest, apoptosis, and/or DNA repair. Here we report that protein palmi...

    Authors: Na Cao, Jia-Kai Li, Yu-Qing Rao, Huijuan Liu, Ji Wu, Baojie Li, Peiquan Zhao, Li Zeng and Jing Li

    Citation: BMC Molecular Biology 2016 17:12

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  5. Content type: Research article

    Non-coding RNAs have gained increasing attention during the last decade. The first large group of non-coding RNAs to be characterized systematically starting at the beginning of the 21st century were small oli...

    Authors: Malte P. Bartram, Elena Amendola, Thomas Benzing, Bernhard Schermer, Gabriella de Vita and Roman-Ulrich Müller

    Citation: BMC Molecular Biology 2016 17:11

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  6. Content type: Methodology article

    Targeted genomic editing using the CRISPR/Cas9 methodology has opened exciting new avenues in probing gene function in virtually any model system, including cultured mammalian cells. Depending on the desired m...

    Authors: Jason A. Estep, Erin L. Sternburg, Gissell A. Sanchez and Fedor V. Karginov

    Citation: BMC Molecular Biology 2016 17:9

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  7. Content type: Research article

    Bothrops colombiensis is a highly dangerous pit viper and responsible for over 70 % of snakebites in Venezuela. Although the composition in B. colombiensis venom has been identified us...

    Authors: Montamas Suntravat, Néstor L. Uzcategui, Chairat Atphaisit, Thomas J. Helmke, Sara E. Lucena, Elda E. Sánchez and A. Rodríguez Acosta

    Citation: BMC Molecular Biology 2016 17:7

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    The Erratum to this article has been published in BMC Molecular Biology 2016 17:13

  8. Content type: Research article

    Breast cancer is the most frequent malignancy in women and drug resistance is the major obstacle for its successful chemotherapy. In the present study, we analyzed the involvement of an oncofetal gene, sal-lik...

    Authors: Yuan-Yuan Chen, Zhi-Zhen Li, Yuan-Yuan Ye, Feng Xu, Rui-Jie Niu, Hong-Chen Zhang, Yi-Jian Zhang, Ying-Bin Liu and Bao-San Han

    Citation: BMC Molecular Biology 2016 17:6

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  9. Content type: Reviewer acknowledgement

    The editors of BMC Molecular Biology would like to thank all our reviewers who have contributed to the journal in Volume 16 (2015).

    Authors: Timothy R. Sands

    Citation: BMC Molecular Biology 2016 17:5

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  10. Content type: Research article

    The genes coding for Y RNAs are evolutionarily conserved in vertebrates. These non-coding RNAs are essential for the initiation of chromosomal DNA replication in vertebrate cells. However thus far, no informat...

    Authors: Quirino Alves de Lima Neto, Francisco Ferreira Duarte Junior, Paulo Sérgio Alves Bueno, Flavio Augusto Vicente Seixas, Madzia Pauline Kowalski, Eyemen Kheir, Torsten Krude and Maria Aparecida Fernandez

    Citation: BMC Molecular Biology 2016 17:1

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  11. Content type: Research article

    Androgens play an important role for the development of male fertility and gained interest as growth and survival factors for certain types of cancer. Androgens act via the androgen receptor (AR/Ar), which is inv...

    Authors: D. Fietz, M. Markmann, D. Lang, L. Konrad, J. Geyer, S. Kliesch, T. Chakraborty, H. Hossain and M. Bergmann

    Citation: BMC Molecular Biology 2015 16:23

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  12. Content type: Research article

    Small non-coding RNAs (sncRNAs) are a class of transcripts implicated in several eukaryotic regulatory mechanisms, namely gene silencing and chromatin regulation. Despite significant progress in their identifi...

    Authors: Ana Raquel Soares, Noémia Fernandes, Marisa Reverendo, Hugo Rafael Araújo, José Luís Oliveira, Gabriela M. R. Moura and Manuel A. S. Santos

    Citation: BMC Molecular Biology 2015 16:22

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  13. Content type: Research article

    Gene expression is an inherently stochastic process, owing to its dynamic molecular nature. Protein amount distributions, which can be acquired by cytometry using a reporter gene, can inform about the mechanis...

    Authors: Ophélie Arnaud, Sam Meyer, Elodie Vallin, Guillaume Beslon and Olivier Gandrillon

    Citation: BMC Molecular Biology 2015 16:20

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    The Erratum to this article has been published in BMC Molecular Biology 2016 17:2

  14. Content type: Research article

    Nuclear receptor family member, Estrogen related receptor β, and the Hedgehog signal transduction pathway are both reported to relate to tumorigenesis and induced pluripotent stem cell reprogramming. We hypoth...

    Authors: Yuan Lu, Jilong Li, Jianlin Cheng and Dennis B. Lubahn

    Citation: BMC Molecular Biology 2015 16:19

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  15. Content type: Research article

    Studies of DNA damage response are critical for the comprehensive understanding of age-related changes in cells, tissues and organisms. Syrian hamster cells halt proliferation and become presenescent after sev...

    Authors: Ljudmila Solovjeva, Denis Firsanov, Anastasia Vasilishina, Vadim Chagin, Nadezhda Pleskach, Andrey Kropotov and Maria Svetlova

    Citation: BMC Molecular Biology 2015 16:18

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  16. Content type: Research article

    mRNA binding proteins (RBPs) constitute 10–15 % of the eukaryotic proteome and play important part in post-transcriptional regulation of gene expression. Due to the instability of RNA and the transient nature ...

    Authors: Nitzan Samra, Avigail Atir-Lande, Lilach Pnueli and Yoav Arava

    Citation: BMC Molecular Biology 2015 16:17

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  17. Content type: Research article

    ALL1-fused from chromosome 1q (AF1q), originally considered as an oncogenic factor, has been implicated in neuronal development; however, its upstream regulatory mechanisms in neural system remained elusive.

    Authors: Yuanyuan Hu, Qianwen Sun, Chen Zhang, Qingquan Sha and Xiulian Sun

    Citation: BMC Molecular Biology 2015 16:15

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  18. Content type: Review

    TRIM28 is a multidomain protein with versatile functions in transcription and DNA repair. Recently it was shown that this factor plays unanticipated roles in transcriptional elongation. TRIM28 was shown to sta...

    Authors: Heeyoun Bunch and Stuart K Calderwood

    Citation: BMC Molecular Biology 2015 16:14

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  19. Content type: Research article

    In gene expression analysis, overlapping genes, splice variants, and fusion transcripts are potential sources of data analysis artefacts, depending on how the observed intensity is assigned to one, or more gen...

    Authors: Rasmus Wernersson, Thomas Frogne, Claude Rescan, Lena Hansson, Christine Bruun, Mads Grønborg, Jan Nygaard Jensen and Ole Dragsbæk Madsen

    Citation: BMC Molecular Biology 2015 16:13

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  20. Content type: Research article

    SIRT6, a member of the NAD+-dependent histone/protein deacetylase family, regulates genomic stability, metabolism, and lifespan. MYH glycosylase and APE1 are two base excision repair (BER) enzymes involved in mut...

    Authors: Bor-Jang Hwang, Jin Jin, Ying Gao, Guoli Shi, Amrita Madabushi, Austin Yan, Xin Guan, Michal Zalzman, Satoshi Nakajima, Li Lan and A-Lien Lu

    Citation: BMC Molecular Biology 2015 16:12

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  21. Content type: Research article

    MicroRNAs, small non-encoding RNAs that post-transcriptionally modulate expression of their target genes, have been implicated as critical regulatory molecules in endothelial cells.

    Authors: Wei-Long Jiang, Yu-Feng Zhang, Qing-Qing Xia, Jian Zhu, Xin Yu, Tao Fan and Feng Wang

    Citation: BMC Molecular Biology 2015 16:11

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  22. Content type: Reviewer acknowledgement

    The editors of BMC Molecular Biology would like to thank all our reviewers who have contributed to the journal in Volume 15 (2014).

    Authors: Tim Sands

    Citation: BMC Molecular Biology 2015 16:10

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  23. Content type: Research article

    Ras pathway mutation leads to induction and Erk phosphorylation and activation of the Ets1 transcription factor. Ets1 in turn induces cyclin E and cyclin dependent kinase (cdk) 2 to drive cell cycle progressio...

    Authors: Kevin C Dean, Li Huang, Yao Chen, Xiaoqin Lu and Yongqing Liu

    Citation: BMC Molecular Biology 2015 16:8

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  24. Content type: Research article

    Box C/D snoRNPs are responsible for rRNA methylation and processing, and are formed by snoRNAs and four conserved proteins, Nop1, Nop56, Nop58 and Snu13. The snoRNP assembly is a stepwise process, involving ot...

    Authors: Marcela B Prieto, Raphaela C Georg, Fernando A Gonzales-Zubiate, Juliana S Luz and Carla C Oliveira

    Citation: BMC Molecular Biology 2015 16:7

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  25. Content type: Research article

    Tendons are dense connective tissues subjected periodically to mechanical stress upon which complex responsive mechanisms are activated. These mechanisms affect not only the development of these tissues but al...

    Authors: Cvetan Popov, Martina Burggraf, Ludwika Kreja, Anita Ignatius, Matthias Schieker and Denitsa Docheva

    Citation: BMC Molecular Biology 2015 16:6

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  26. Content type: Methodology article

    With the introduction of the first high-throughput qPCR instrument on the market it became possible to perform thousands of reactions in a single run compared to the previous hundreds. In the high-throughput r...

    Authors: Vlasta Korenková, Justin Scott, Vendula Novosadová, Marie Jindřichová, Lucie Langerová, David Švec, Monika Šídová and Robert Sjöback

    Citation: BMC Molecular Biology 2015 16:5

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  27. Content type: Research article

    The Wnt signaling pathway is involved in the control of cell proliferation and differentiation during skeletal muscle development. Secreted frizzled-related proteins (SFRPs), such as SFRP1, function as inhibitors...

    Authors: Yalan Yang, Wei Sun, Ruiqi Wang, Chuzhao Lei, Rong Zhou, Zhonglin Tang and Kui Li

    Citation: BMC Molecular Biology 2015 16:4

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  28. Content type: Methodology article

    Ribosomes and functional complexes of them have been analyzed at the atomic level. Far less is known about the dynamic assembly and degradation events that define the half-life of ribosomes and guarantee their...

    Authors: Rainer Nikolay, Renate Schloemer, Silke Mueller and Elke Deuerling

    Citation: BMC Molecular Biology 2015 16:3

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  29. Content type: Research article

    ATPase/Helicases and nucleases play important roles in homologous recombination repair (HRR). Many of the mechanistic details relating to these enzymes and their function in this fundamental and complicated DN...

    Authors: Qihong Huang, Linlin Liu, Junfeng Liu, Jinfeng Ni, Qunxin She and Yulong Shen

    Citation: BMC Molecular Biology 2015 16:2

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  30. Content type: Research article

    The glomerular podocyte is a highly specialized cell type with the ability to ultrafilter blood and support glomerular capillary pressure. However, little is known about the genetic programs leading to this fu...

    Authors: Shuang Yang, Lingjia Liu, Pengjuan Xu and Zhuo Yang

    Citation: BMC Molecular Biology 2015 16:1

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  31. Content type: Research article

    Transposable elements (TEs, transposons) are mobile genetic DNA sequences. TEs can insert copies of themselves into new genomic locations and they have the capacity to multiply. Therefore, TEs have been crucia...

    Authors: Guang-Hua Luo, Xiao-Huan Li, Zhao-Jun Han, Hui-Fang Guo, Qiong Yang, Min Wu, Zhi-Chun Zhang, Bao-Sheng Liu, Lu Qian and Ji-Chao Fang

    Citation: BMC Molecular Biology 2014 15:28

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  32. Content type: Research article

    Premature aging syndromes recapitulate many aspects of natural aging and provide an insight into this phenomenon at a molecular and cellular level. The progeria syndromes appear to cause rapid aging through di...

    Authors: Nicolas Paquet, Joseph K Box, Nicholas W Ashton, Amila Suraweera, Laura V Croft, Aaron J Urquhart, Emma Bolderson, Shu-Dong Zhang, Kenneth J O’Byrne and Derek J Richard

    Citation: BMC Molecular Biology 2014 15:27

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  33. Content type: Methodology article

    Comprehensive understanding of mechanisms of genome functions requires identification of molecules interacting with genomic regions of interest in vivo. We previously developed the insertional chromatin immunopre...

    Authors: Toshitsugu Fujita and Hodaka Fujii

    Citation: BMC Molecular Biology 2014 15:26

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  34. Content type: Research article

    Mice and humans produce chitinase-like proteins (CLPs), which are highly homologous to chitinases but lack chitinolytic activity. Mice express primarily three CLPs, including breast regression protein-39 (BRP-...

    Authors: Misa Ohno, Yuta Kida, Masayoshi Sakaguchi, Yasusato Sugahara and Fumitaka Oyama

    Citation: BMC Molecular Biology 2014 15:23

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  35. Content type: Research article

    The GBGT1 gene encodes the globoside alpha-1,3-N-acetylgalactosaminyltransferase 1. This enzyme catalyzes the last step in the multi-step biosynthesis of the Forssman (Fs) antigen, a pentaglycosyl ceramide of the...

    Authors: Francis Jacob, Megan P Hitchins, André Fedier, Kevin Brennan, Sheri Nixdorf, Neville F Hacker, Robyn Ward and Viola A Heinzelmann-Schwarz

    Citation: BMC Molecular Biology 2014 15:24

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  36. Content type: Research article

    Wingless gene (Wg) plays a fundamental role in regulating the segment polarity and wing imaginal discs of insects. The rice planthoppers have an obvious wing dimorphism, and the long- and short-winged forms exist...

    Authors: Ju-Long Yu, Zhi-Fang An and Xiang-Dong Liu

    Citation: BMC Molecular Biology 2014 15:20

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  37. Content type: Research article

    The transcription factor Pax8 is expressed during thyroid development and is involved in the morphogenesis of the thyroid gland and maintenance of the differentiated phenotype. In particular, Pax8 has been shown ...

    Authors: Maria Grazia Filippone, Tina Di Palma, Valeria Lucci and Mariastella Zannini

    Citation: BMC Molecular Biology 2014 15:21

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  38. Content type: Research article

    Trans-translation is catalyzed by ribonucleprotein complexes composed of SmpB protein and transfer-messenger RNA. They release stalled ribosomes from truncated mRNAs and tag defective proteins for proteolytic deg...

    Authors: Iwona K Wower, Christian Zwieb and Jacek Wower

    Citation: BMC Molecular Biology 2014 15:19

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