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  1. Research article

    RNA polymerase II depletion promotes transcription of alternative mRNA species

    Cells respond to numerous internal and external stresses, such as heat, cold, oxidative stress, DNA damage, and osmotic pressure changes. In most cases, the primary response to stress is transcriptional induct...

    Lijian Yu, Mayuri Rege, Craig L. Peterson and Michael R. Volkert

    BMC Molecular Biology 2016 17:20

    Published on: 30 August 2016

  2. Research article

    Distinct recruitment of human eIF4E isoforms to processing bodies and stress granules

    Eukaryotic translation initiation factor 4E (eIF4E) plays a pivotal role in the control of cap-dependent translation initiation, modulates the fate of specific mRNAs, occurs in processing bodies (PBs) and is r...

    Klara Frydryskova, Tomas Masek, Katerina Borcin, Silvia Mrvova, Veronica Venturi and Martin Pospisek

    BMC Molecular Biology 2016 17:21

    Published on: 30 August 2016

  3. Review

    Nucleophosmin: from structure and function to disease development

    Nucleophosmin (NPM1) is a critical cellular protein that has been implicated in a number of pathways including mRNA transport, chromatin remodeling, apoptosis and genome stability. NPM1 function is a critical ...

    Joseph K. Box, Nicolas Paquet, Mark N. Adams, Didier Boucher, Emma Bolderson, Kenneth J. O’Byrne and Derek J. Richard

    BMC Molecular Biology 2016 17:19

    Published on: 24 August 2016

  4. Research article

    Stearoyl-CoA desaturase 1 expression is downregulated in liver and udder during E. coli mastitis through enhanced expression of repressive C/EBP factors and reduced expression of the inducer SREBP1A

    Stearoyl-CoA desaturase 1 (SCD1) desaturates long chain fatty acids and is therefore a key enzyme in fat catabolism. Its synthesis is downregulated in liver during illnesses caused by high levels of circulatin...

    Tianle Xu, Xiangzhen Shen and Hans-Martin Seyfert

    BMC Molecular Biology 2016 17:16

    Published on: 20 July 2016

  5. Research Article

    Confirmation of translatability and functionality certifies the dual endothelin1/VEGFsp receptor (DEspR) protein

    In contrast to rat and mouse databases, the NCBI gene database lists the human dual-endothelin1/VEGFsp receptor (DEspR, formerly Dear) as a unitary transcribed pseudogene due to a stop [TGA]-codon at codon#14 in ...

    Victoria L. M. Herrera, Martin Steffen, Ann Marie Moran, Glaiza A. Tan, Khristine A. Pasion, Keith Rivera, Darryl J. Pappin and Nelson Ruiz-Opazo

    BMC Molecular Biology 2016 17:15

    Published on: 14 June 2016

  6. Research article

    Strong preference of BRCA1 protein to topologically constrained non-B DNA structures

    The breast and ovarian cancer susceptibility gene BRCA1 encodes a multifunctional tumor suppressor protein BRCA1, which is involved in regulating cellular processes such as cell cycle, transcription, DNA repair, ...

    Václav Brázda, Lucia Hároníková, Jack C. C. Liao, Helena Fridrichová and Eva B. Jagelská

    BMC Molecular Biology 2016 17:14

    Published on: 8 June 2016

  7. Research article

    A potential role for protein palmitoylation and zDHHC16 in DNA damage response

    Cells respond to DNA damage by activating the phosphatidylinositol-3 kinase-related kinases, p53 and other pathways to promote cell cycle arrest, apoptosis, and/or DNA repair. Here we report that protein palmi...

    Na Cao, Jia-Kai Li, Yu-Qing Rao, Huijuan Liu, Ji Wu, Baojie Li, Peiquan Zhao, Li Zeng and Jing Li

    BMC Molecular Biology 2016 17:12

    Published on: 10 May 2016

  8. Research article

    Mice lacking microRNAs in Pax8-expressing cells develop hypothyroidism and end-stage renal failure

    Non-coding RNAs have gained increasing attention during the last decade. The first large group of non-coding RNAs to be characterized systematically starting at the beginning of the 21st century were small oli...

    Malte P. Bartram, Elena Amendola, Thomas Benzing, Bernhard Schermer, Gabriella de Vita and Roman-Ulrich Müller

    BMC Molecular Biology 2016 17:11

    Published on: 18 April 2016

  9. Methodology article

    Immunoblot screening of CRISPR/Cas9-mediated gene knockouts without selection

    Targeted genomic editing using the CRISPR/Cas9 methodology has opened exciting new avenues in probing gene function in virtually any model system, including cultured mammalian cells. Depending on the desired m...

    Jason A. Estep, Erin L. Sternburg, Gissell A. Sanchez and Fedor V. Karginov

    BMC Molecular Biology 2016 17:9

    Published on: 2 April 2016

  10. Methodology article

    A reliable method for quantification of splice variants using RT-qPCR

    The majority of protein isoforms arise from alternative splicing of the encoding primary RNA transcripts. To understand the significance of single splicing events, reliable techniques are needed to determine t...

    Julia Camacho Londoño and Stephan E. Philipp

    BMC Molecular Biology 2016 17:8

    Published on: 15 March 2016

  11. Research article

    Gene expression profiling of the venom gland from the Venezuelan mapanare (Bothrops colombiensis) using expressed sequence tags (ESTs)

    Bothrops colombiensis is a highly dangerous pit viper and responsible for over 70 % of snakebites in Venezuela. Although the composition in B. colombiensis venom has been identified us...

    Montamas Suntravat, Néstor L. Uzcategui, Chairat Atphaisit, Thomas J. Helmke, Sara E. Lucena, Elda E. Sánchez and A. Rodríguez Acosta

    BMC Molecular Biology 2016 17:7

    Published on: 5 March 2016

    The Erratum to this article has been published in BMC Molecular Biology 2016 17:13

  12. Research article

    Knockdown of SALL4 inhibits the proliferation and reverses the resistance of MCF-7/ADR cells to doxorubicin hydrochloride

    Breast cancer is the most frequent malignancy in women and drug resistance is the major obstacle for its successful chemotherapy. In the present study, we analyzed the involvement of an oncofetal gene, sal-lik...

    Yuan-Yuan Chen, Zhi-Zhen Li, Yuan-Yuan Ye, Feng Xu, Rui-Jie Niu, Hong-Chen Zhang, Yi-Jian Zhang, Ying-Bin Liu and Bao-San Han

    BMC Molecular Biology 2016 17:6

    Published on: 2 March 2016

  13. Reviewer acknowledgement

    Annual acknowledgement of reviewers

    The editors of BMC Molecular Biology would like to thank all our reviewers who have contributed to the journal in Volume 16 (2015).

    Timothy R. Sands

    BMC Molecular Biology 2016 17:5

    Published on: 19 February 2016

  14. Research article

    Structural and functional analysis of four non-coding Y RNAs from Chinese hamster cells: identification, molecular dynamics simulations and DNA replication initiation assays

    The genes coding for Y RNAs are evolutionarily conserved in vertebrates. These non-coding RNAs are essential for the initiation of chromosomal DNA replication in vertebrate cells. However thus far, no informat...

    Quirino Alves de Lima Neto, Francisco Ferreira Duarte Junior, Paulo Sérgio Alves Bueno, Flavio Augusto Vicente Seixas, Madzia Pauline Kowalski, Eyemen Kheir, Torsten Krude and Maria Aparecida Fernandez

    BMC Molecular Biology 2016 17:1

    Published on: 5 January 2016

  15. Research article

    Transfection of Sertoli cells with androgen receptor alters gene expression without androgen stimulation

    Androgens play an important role for the development of male fertility and gained interest as growth and survival factors for certain types of cancer. Androgens act via the androgen receptor (AR/Ar), which is inv...

    D. Fietz, M. Markmann, D. Lang, L. Konrad, J. Geyer, S. Kliesch, T. Chakraborty, H. Hossain and M. Bergmann

    BMC Molecular Biology 2015 16:23

    Published on: 29 December 2015

  16. Research article

    Conserved and highly expressed tRNA derived fragments in zebrafish

    Small non-coding RNAs (sncRNAs) are a class of transcripts implicated in several eukaryotic regulatory mechanisms, namely gene silencing and chromatin regulation. Despite significant progress in their identifi...

    Ana Raquel Soares, Noémia Fernandes, Marisa Reverendo, Hugo Rafael Araújo, José Luís Oliveira, Gabriela M. R. Moura and Manuel A. S. Santos

    BMC Molecular Biology 2015 16:22

    Published on: 22 December 2015

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