Computational modeling and in silico analysis of differential regulation of myo-inositol catabolic enzymes in Cryptococcus neoformans

Table 5 Stabilizing Amino Acids Involved in Main-Chain Hydrogen Bonds.

Protein	Amino Acid	Amino Acid	Amino Acid
MIOX3	Val 109	Arg-116	Gln-211
MIOX2	Val-61	Arg-68	Gln-163
MIOX1	Glu-66	Arg-71	Gln-168
musculus	Thr-32	Arg-39	Gln-136

The main chain hydrogen bonds involving Arg and Gln are predicted to be conserved in all four proteins. MIOX2 and MIOX3 protein share a substitution of Val for Thr disrupting the main chain hydrogen bond found at that location in the Mus musculus protein. MIOX1 protein has a conservative substitution of Glu for Thr suggesting the preservation of that main chain hydrogen bond.

ISSN: 1471-2199