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Figure 3 | BMC Molecular Biology

Figure 3

From: Down-regulation of human topoisomerase IIα expression correlates with relative amounts of specificity factors Sp1 and Sp3 bound at proximal and distal promoter regions

Figure 3

Sp1 and Sp3 are antagonistic at the topoisomerase IIα promoter. All transfections were performed in triplicate with 1.0 μg of -617 wt topoisomerase IIα reporter plasmid and 1 μg of pCMV Sport β-galactosidase control vector. Relative luciferase activity was calculated by arbitrarily setting the control (0 μg, containing only topoisomerase IIα reporter plasmid and pCMV Sport β-galactosidase control vector) to 100%. Results are expressed as ± SEM where n = 9, *** p < 0.001, ** p < 0.01, and * p < 0.05.

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BMC Molecular Biology

ISSN: 1471-2199

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