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Table 1 S. cerevisiae DNA polymerases and proteins that participate in the five primary DNA repair pathways.

From: Stripped-down DNA repair in a highly reduced parasite

Base Excision Repair (BER) Nucleotide Excision Repair (NER)
Gene Name Present in E. cuniculi S. cerevisiae Protein ID E. cuniculi Protein ID Gene Name Present in E. cuniculi S. cerevisiae Protein ID E. cuniculi Protein ID
Apn1 Y CAA81954 CAD26065 Rad1 (XPF) Y P06777 CAD26381
Apn2 Y NP_009534 NP_585892 Rad2 (XPG) Y CAA97287 CAD27314/XP_955715
Mag1 Y NP_011069 CAD25924/CAD26679 Rad3 (Ercc2/XPD) Y CAA46255 NP_585776
Mus81 Y NP_010674 NP_584664 Rad4 (XPC) Y CAA39375 CAD24914
Ntg1 Y NP_009387 CAD26394 Rad10 (Ercc1) Y CAA86642 CAD25852/NP_586248
Ogg1 Y NP_013651 CAD26383 Rad14 (XPA) Y P28519 NP_586232
PCNA Y AAS56041 NP_597446 Rad25 (Ssl2/XPB) Y Q00578 CAD24977
Rad1 (XPF) Y P06777 CAD26381 Rad26 (Ercc6/CSB) Y CAA57290 CAD27013/XP_955594
Rad10 (Ercc1) Y CAA86642 CAD25852/NP_586248 Rpa1 Y NP_009404 CAD25779
Rad27 (Fen1) Y CAA81953 CAD26252 Rpa2 Y NP_014087 CAD25396
Ung1 Y CAA86634 CAD26772 Ssl1 Y CAA97527 CAD25215
* Xrcc1 (Cut5) Y P32372 NP_584657 Tfb2 Y AAB40628 CAD24937
Cdc9 (DNA lig I) N CAA48158 - Tfb3 Y AAB64899 CAD25932
Ddc1 (Rad9) N NP_015130 - Tfb4 Y NP_015381 CAD25620
Mec3 (Hus1) N NP_013391 - Rad7 ? CAA85071 -
Mms4 N NP_009656 - Rad16 ? CAA89580 -
Rad17 (Rad1) N CAA99699 - Rad23 (HR23B) N AAB28441 -
     Tfb1 N AAB64747 -
Methyltransferase Repair DNA Polymerases
Gene Name Present in E. cuniculi S. cerevisiae Protein ID E. cuniculi Protein ID Gene Name Present in E. cuniculi S. cerevisiae Protein ID E. cuniculi Protein ID
Mgt1 N CAA42920 - α Pol1 Y AAZ22505 CAD26619
     α Pol12 Y NP_009518 CAD25827
Mismatch Repair (MMR) α Pri1 Y AAT92878 CAD26368
Gene Name Present in E. cuniculi S. cerevisiae Protein ID E. cuniculi Protein ID α Pri2 Y NP_012879 CAD26641
     δ Pol3 Y CAA43922 CAD27015
Exo1 Y NP_014676 CAD25986 δ Hys2 Y NP_012539 CAD27050
Mlh1 Y NP_013890 NP_597370 ε Dpb2 Y NP_015501 NP_597373
Msh2 Y CAA99102 CAD26200/NP_597565 ε Pol2 Y NP_014137 CAD25840
Msh6 Y NP_010382 NP_586186 β Pol4 N NP_009940 -
PCNA Y AAS56041 NP_597446 γ Mip1 N NP_014975 -
Pms1 Y P14242 NP_586432 η Rad30 N NP_010707 -
Msh3 N CAA42247 - ζ Rev3 N NP_015158 -
     ζ Rev7 N AAA98667 -
     Rev1 N CAA99674 -
Homologous Recombination (HRR) Non-Homologous End Joining (NHEJ)
Gene Name Present in E. cuniculi S. cerevisiae Protein ID E. cuniculi Protein ID Gene Name Present in E. cuniculi S. cerevisiae Protein ID E. cuniculi Protein ID
Mre11 (Rad32) Y BAA02017 CAD26648/NP_597471 Mre11 (Rad32) Y BAA02017 CAD26648/NP_597471
Rad50 Y CAA65494 CAD25593/NP_585989 Rad27 (Fen1) Y CAA81953 CAD26252
Rad51 Y CAA45563 CAD25992/NP_586388 Rad50 Y CAA65494 CAD25593/NP_585989
Rad52 Y CAA86623 XP_955647 Lif1 (Xrcc4) ? NP_011425 -
Rpa1 Y NP_009404 CAD25779 *Xrs2 (Nbs1) ? BAC80248 -
Rpa2 Y NP_014087 CAD25396 Ddc1 (Rad9) N NP_015130 -
Sgs1 Y NP_013915 CAD25646 Dnl4 N CAA99193 -
Rad55 (Rad51C) ? BAA01284 - Mec3 (Hus1) N NP_013391 -
Rad57 (Xrcc3) ? NP_010287 - Ku70 N NP_014011 -
*Xrs2 (Nbs1) ? BAC80248 - Ku80 N NP_013824 -
Ddc1 (Rad9) N NP_015130 - Rad17 (Rad1) N CAA99699 -
Hpr5 (Srs2) N CAA89385 -     
Mec3 (Hus1) N NP_013391 -     
Rad17 (Rad1) N CAA99699 -     
Rad24 (Rad17) N P32641 -     
Rad54 N CAA88534 -     
Rdh54 (Rad54B) N CAA85017 -     
  1. Presence or absence in E. cuniculi is indicated (as defined in Methods), along with the genbank accession numbers for both S. cerevisiae and E. cuniculi proteins. Absent proteins are presented in bold type. Italicized accession numbers indicate that the presence or absence of these proteins in E. cuniculi was unclear. (See results for more information.) When S. pombe proteins appeared to be more conserved among eukaryotes than S. cerevisiae homologues (or where S. cerevisiae homologues do not exist), they were used to conduct the BLAST and PSI-BLAST searches. These proteins are marked with asterixes. S. cerevisiae nomenclature is used, with S. pombe or animal homologues given in brackets. Pathway components were largely compiled from the following sources: MMR from Marti et al. [22], BER from Boiteux and Guillet [12], NER from Prakash and Prakash [17], NHEJ from Daley et al. [57], HRR from Aylon and Kupiec [24], DNA polymerases from Burgers [58] and Hubscher et al., [4].