Figure 1

The human OXR1 gene. Top: The genomic structure of OXR1 consists of 16 known exons located on chromosome 8q23. Exons, or portions of exons shown in black are present in an oxidation resistance active form of OXR1 previously described [24], whereas exons in white are known to be dispensable for this activity. Exon 10 is found in a variant that begins with exon 10 and includes exons 12 through 15 [43]. Bottom: The protein sequences encoded by OXR1 exons 7 through 16 are listed. The starting points for the series of OXR1 N-terminal truncations were constructed by placing an ATG at the codon prior to position 203 (shaded lysine) of exon 7, using the methionine codon at position 225 (shaded) in exon 7, or by placing an ATG start codon in front of the codons encoding the first residues listed for exons 8 through 13 (except exon 10). The end points for the series of OXR1 C-terminal truncations are denoted by the arrows. Exon 10 is listed here, but was not found in pMV520; it is shown here for completeness.