Fig. 6

PSMD1 and PSMD2 regulate cellular lipid metabolism. HepG2 cells were seeded in the 6-well plate. Then, the cells were transfected with PSMD1/PSMD2 siRNAs or SREBF1/PPARγ overexpression vectors or control siRNA or a control overexpression vector. a, d Cell proliferation capacity was monitored by the EdU assay. b, e Statistical analysis was performed on the EdU assay. The magnification is 200×. Results are shown as the mean ± SEM of three independent experiments. Independent sample t-tests were used to analyze the statistical differences between groups. *p < 0.05; **p < 0.01. c, f Relative mRNA expression of the cell-cycle-related genes. Independent sample t-tests were used to analysis the statistical differences between groups (n = 3), *p < 0.05; **p < 0.01