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Fig. 7 | BMC Molecular Biology

Fig. 7

From: MicroRNA-325-3p protects the heart after myocardial infarction by inhibiting RIPK3 and programmed necrosis in mice

Fig. 7

Target relationship between miR-325-3p and RIPK3. a The binding sites between the 3′UTR of RIPK3 and miR-325-3p predicted by TargetScanHuman 7.2. b A dual-luciferase reporter assay validated the target relationship between miR-325-3p and the 3′UTR of RIPK3. **P < 0.01 between the wild-type and mutated 3′UTR of RIPK3. c, d The differential expression of RIPK3 mRNA (c) or protein (d) in the sham-operated mice and the MI mice. **P < 0.01 compared to the mice that received the sham operation. e, f The influence of miR-325-3p dysregulation on the expression of RIPK3 mRNA (e) and protein (f) in MI mice. **P < 0.01 compared to MI mice treated with agomiR-control. MI, myocardial infarction; agomiR-325-3p, miR-325-3p agomir; antagomiR-325-3p, miR-325-3p antagomir; agomiR-control, scrambled agomir or antagomir control; RIPK3, receptor-interacting serine/threonine protein kinase 3

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