Skip to main content


Fig. 5 | BMC Molecular Biology

Fig. 5

From: MicroRNA-325-3p protects the heart after myocardial infarction by inhibiting RIPK3 and programmed necrosis in mice

Fig. 5

Influences of miR-325-3p dysregulation on the apoptosis of cardiomyocytes in MI mice. a Representative images of cardiac tissues that were stained with TUNEL (green), DAPI (blue) and the merge images of TUNEL and DAPI are shown. b The quantification of TUNEL-positive cells. c The Western blot results of RIPK1, RIPK3 and p-MLKL. Representative images (top) and quantitative comparison (bottom) are shown. **P < 0.01 compared to the mice that received the sham operation, #P < 0.05 compared to MI mice. MI, myocardial infarction; agomiR-325-3p, miR-325-3p agomir; antagomiR-325-3p, miR-325-3p antagomir; agomiR-control, scrambled agomir or antagomir control; TUNEL, terminal deoxynucleotidyl transferase dUTP nick-end labeling; DAPI, 4-6-diamidino-2-phenylindole; RIPK1, receptor-interacting serine/threonine protein kinase 1; RIPK3, receptor-interacting serine/threonine protein kinase 3; p-MLKL, phosphorylated mixed-lineage kinase domain-like protein

Back to article page