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Table 4 Functional pathways altered in transcriptome and proteome analyses in KEGG database

From: Integration of transcriptome and proteome profiles in glioblastoma: looking for the missing link

Pathway Genes Official gene symbol Fold change P-value TNC
Transcriptomic
hsa04080: neuroactive ligand–receptor interaction 18 GABRG1, GABRD, GABRG2, GABRA2, GABRA1, CCKBR, GRIN1, OXTR, GABBR2, GRM1, GRIN2C, SSTR1, PRSS2, PRSS3, ADRA1B, HTR5A, F2R, HTR2A 3.69 < 0.01 3103
hsa04020: calcium signaling pathway 14 CCKBR, GRIN1, OXTR, ITPKA, GRM1, ATP2B3, GRIN2C, ADRA1B, RYR2, CAMK2B, CAMK2A, HTR5A, F2R, HTR2A 4.17 < 0.01 3111
hsa04512: ECM-receptor interaction 10 IBSP, COL4A2, COL4A1, CD44, TNC, COL3A1, COL1A2, SV2B, COL1A1, FN1 6.24 < 0.01 3125
hsa00910: nitrogen metabolism 4 GLS2, CA9, CA12, GLS 9.12 0.19 3076
hsa04720: long-term potentiation 6 GRIN2C, PPP1R1A, GRIN1, CAMK2B, CAMK2A, GRM1 4.63 0.15 3157
hsa05014: amyotrophic lateral sclerosis 5 SLC1A2, GRIN2C, GRIN1, NEFH, NEFL 4.95 0.24 3125
hsa04510: focal adhesion 9 IBSP, PAK6, COL4A2, COL4A1, TNC, COL3A1, COL1A2, COL1A1, FN1 2.35 0.38 3103
hsa00471: d-glutamine and d-glutamate metabolism 2 GLS2, GLS 26.21 0.59 3333
Proteomic
hsa05130: pathogenic Escherichia coli infection 5 ACTB, TUBB2A, TUBB2C, TUBB4, YWHAZ 19.39 0.00 30
hsa00010: glycolysis/gluconeogenesis 4 ALDOA, PGAM1, HK1, ENO1 14.74 0.04 30
  1. TNC total number of components in each pathway