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Table 1 Patient characteristics

From: Recommendations for mRNA analysis of micro-dissected glomerular tufts from paraffin-embedded human kidney biopsy samples

  Diagnosis Female Age at biopsy Hypertension Hematuria Proteinuria Creatinine (mg/dl)
Cohort I        
  - ATN (9/9)
- Mild interstitial inflammation (4/9)
- Mild interstitial nephritis (5/9)
5/9 37 (20/63) 1/9 4/9 7/9 3.1 (1.6/5.3)
Cohort II        
  - Unspecific minimal structural changes
- Acute tubular injury
- Lupusnephritis class II
- Hypertensive ischemic nephropathy
- Diabetic nephropathy
- Minimal change disease
- Primary focal-segmental Glomerulosclerosis
- Humoral rejection type II (n = 3)
- Acute tubular injury after transplantation (n = 4)
- Mild interstitial fibrosis after transplantation
7/15 50 (37/61) 9/15 3/13 6/13 1.5 (0.8/3.1)
  1. Main data of the different cohorts are summarized: Cohort (I) for micro-dissection of glomerular substructures, cohort (II) for comparing different glomeruli counts and for reference transcript analysis. Cohort (I) comprised of nine patients with non-glomerular diseases, and cohort (II) of fifteen patients (seven native and eight transplant biopsies) randomly selected by a high number of glomeruli per biopsy. Two patients were on dialysis and no data for proteinuria and hematuria were available. There was a significant difference for hypertension between cohort I and II (p = 0.0234; Mann–Whitney U test). Data are given as median (25th/75th percentiles) or absolute values