Fig. 7
From: Deciphering targeting rules of splicing modulator compounds: case of TG003
Model of mechanism of TG003 exon skip enhancement. Model of mechanism of TG003 exon skip-enhancement. We showed that TG003 skip-enhanced exons have weak polypyrimidine tract, which is known to be bound by U2AF65. Some exons require support from other splicing factors for splicing reaction. Treatment of TG003 might result in exon skipping by the loss of the support