Fig. 2

Representation of mechanisms of association of TRIM28 with chromatin and influences in transcriptional function. TRIM28 is depicted as associating with KRAB factors through the RBCC domain and with HP1 factors associated with H1K9Me3 though the HP1 binding motif. The sumoylated BR domain is represented as interacting with both CHH3/Mi2/NuRD complexes and with SETDB1 and mediating trans-repression.