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Figure 4 | BMC Molecular Biology

Figure 4

From: Transcriptional profile of the homologous recombination machinery and characterization of the EhRAD51 recombinase in response to DNA damage in Entamoeba histolytica

Figure 4

Comparison of the predicted amino acids sequence of EhRAD51 with other RAD51 proteins. A. Multiple sequence alignments of functional domains of RAD51 from E. histolytica (EhRAD51), S. cerevisiae (ScRAD51) and H. sapiens (HsRAD51) proteins. Upper panel: Glutamate-rich region, polymerization motif (PM), Walker A and B motif, L1 and L2 regions and ATP cap appear as colored boxes. Lower panel: black boxes, identical aa; grey boxes, conserved substitutions; open box, Glutamate-rich region. Numbers at the left are relative to the position of the initial methionine in each protein. Accession numbers and protein lengths are indicated in the Supplementary Table S1. B. Phylogenetic relationships between EhRAD51 and RECA/RAD51 family members. The unrooted tree was created with the MEGA 3.1 program using the Neighbor Joining algorithm based on ClustalW alignments of complete amino acids sequences. Numbers above the tree nodes indicate the percentage of times that the branch was recovered in 1000 replications.

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BMC Molecular Biology

ISSN: 1471-2199

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