Figure 2

Comparative transcription factor binding site analysis of ADAM15 promoter. The human ADAM15 promoter and the first exon nucleotide sequences were aligned with corresponding mouse and rat sequences (hsA15, mmA15, and rnA15, respectively). The numbering above the sequences indicates position respective to the adenine in the translation start codon. The amino acid translation is shown for the first exon of human ADAM15. The predicted high-score transcription factor recognition motifs are indicated above the sequence (solid line, human; dotted line, mouse; dashed line, rat). The three conserved 22 bp repeated elements, the translation start ATG, and the polyadenylation signal of the upstream gene FLJ32785 are boxed. The boxed GTs indicate the detected splice donor sites in the last FLJ32785 exon used in splicing of human FLJ32785 to ADAM15. The thick line below the aligned sequences indicates the region containing the detected transcription start sites of the human ADAM15 gene.