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Figure 1 | BMC Molecular Biology

Figure 1

From: Somatic CTG•CAG repeat instability in a mouse model for myotonic dystrophy type 1 is associated with changes in cell nuclearity and DNA ploidy

Figure 1

Effects of aging on the somatic CTG•CAG repeat length distribution in heart, liver and pancreas. Typical CTG•CAG length profiles of genomic DNA isolated from heart (A), liver (B) or pancreas (C) of a knock-in mouse model carrying a humanized DMPK gene with a (CTG•CAG)n repeat [13]. Arrows indicate the position of the progenitor allele determined from analysis of tail DNA at time of weaning. Note the slow but uniform broadening of the profile with slight shift towards greater repeat lengths upon aging in heart, in contrast to the bimodal repeat length distribution in liver and pancreas.

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