Table 1 Overview of GAPDH expression by different tumor and non-tumor cell lines as a consequence of the development of a hypoxic cellular microenvironment
From: GAPDH is not regulated in human glioblastoma under hypoxic conditions
Cell line or type | Origin | Genetic mutations (-/+) | GAPDH overexpression under hypoxia | Ref. GAPDH | Ref. mutations |
|---|---|---|---|---|---|
LNCap | - Human prostate adenocarcinoma cells | - No mutations | + | [35] | [27] |
ATII | -Rat alveolar epithelial cells | - No mutations | + | [26] | [26] |
SiHA | -Human spontaneous cervical cancer cells | - No mutations Wild type p53 | + | [36] | [37] |
MBEC4 | -Mouse brain capillary endothelial cells | - No mutations | + | [38] | [38] |
EC | - Human endothelial cells | - Not determined Mutated epithelial cells are present | + | [5], [22], [23], [24] [39], [40] | [40] |
Skeletal muscles from hindlimbs of newborn white New Zealand rabbits | - Rabitts skeletal muscle cells | - Not determined | + | [41] | - |
Bovine articular chondrocytes | -Bovine chondrocytes | - Not determined | - | [38] | - |
U373 – MG | -Human malignant glioma cells | -Apoptosis resistant mutant P53 - Peroxisome proliferator activated receptor – γ - PTEN mutation | - | - | [42], [43], [44], |
GaMG | -Human malignant glioma cells | - No mutations | - | - | [34], [44] |
U251 | -Human malignant glioma cells | -Mutated p53 – P14ARF/P16 deletion | - | - | [43], [46] |