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Figure 5 | BMC Molecular Biology

Figure 5

From: Interleukin-4 inhibition of interleukin-1-induced expression of matrix metalloproteinase-3 (MMP-3) is independent of lipoxygenase and PPARγ activation in human gingival fibroblasts

Figure 5

Pioglitazone fails to inhibit IL-1 induced MMP-3. HGF cultures were pre-treated with pioglitazone at the indicated doses for one hour before addition of IL-1 (10 ng/ml). Total RNA was isolated at 6 hours, quantitated by real-time PCR and normalized to levels of GAPDH. The graph represents data from three independent experiments performed in triplicate, mean +/- SEM. Statistical significance was determined by Students T-test, p = 0.025 at 1 μM, 0.06 at 10 μM vs IL-1 alone.

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BMC Molecular Biology

ISSN: 1471-2199

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