Phylogenetic (NJ) tree of SVSPs. Sequences (complete ORF) available from other pit vipers  and 11 isoforms (DQ464238–DQ464248) from this study (filled circle) were used. Tissue kallikrein-1 (P06870) is used as outgroup. The numbers on the branches indicate the bootstrap support values for nodes, and the horizontal bar represents number of substitutions per site. TLE, thrombin-like enzymes; KN, kininogenase; PA, plasminogen activator; PAI, platelet aggregation inducer; BCD, blood clot dispersion; X, activity unknown. Experimentally verified activities are shaded.