Figure 5

Schema of the entrainment mechanism by 15d-PGJ ₂ . 15d-PGJ₂ up-regulates transcription of Cry s and Rorα (Fig. 5Bi). The translated RORα activates Bmal1 transcription, and translated BMAL1 then binds to CLOCK and their heterodimers activate Per/Cry and Rev-erb transcriptions via E/E' box (Fig. 5Bii). Translated PER/CRY and REV-ERB inhibit Per/Cry/Rev-erb and Bmal1 transcription, respectively (Fig. 5Biii). The inhibition of Rev-erb transcription reduces Bmal1 transcription (Fig. 5Biv). The reduced Per/Cry transcription and relatively increased RORα activity (by inhibition of REV-ERB) again up-regulate Bmal1 transcription (Fig. 5Biv -> 5Bii).