Figure 1From: Locked nucleoside analogues expand the potential of DNAzymes to cleave structured RNA targetsA. Schematic of a 10–23 DNAzyme hybridized via Watson-Crick base-pairing to an RNA substrate. The underlined sequence indicates the region where the LNA-type monomers were introduced (Table 1). Pu, purine; Py, pyrimidine. B. Structures of LNA (locked nucleic acid) and α-L-LNA nucleoside monomers.Back to article page