Figure 6

Alternative splicing in the 5' end of GLI2 mRNA. Exons corresponding to cloned and/or sequenced splice variants are marked by bold lines. Exon and intron splice junction sequences are designated by upper and lower case letters, respectively. Alternatively spliced forms I-III arising via exon skipping and different exon 6–7 junction usage (described in this study) are compared with the previously published sequence (Type IV) [32]. For each alternatively spliced form, GenBank accession number is shown on the right. Translation of these sequences initiated from ATG codon located in exon 2 (METSA) terminates with premature termination codons (PTC). Location of initiator codon described previously [32] is shown in exon 7 (M). Location of the SUFU binding site (SYGH) in exon 6 is shown.