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Figure 8 | BMC Molecular Biology

Figure 8

From: Glucocorticoids synergize with IL-1β to induce TLR2 expression via MAP Kinase Phosphatase-1-dependent dual Inhibition of MAPK JNK and p38 in epithelial cells

Figure 8

Schematic representation of the signaling pathways involved in glucocorticoid-mediated enhancement of IL-1β-induced TLR2 expression via MKP-1-dependent inhibition of p38 and JNK in human epithelial cells. IL-1β up-regulates TLR2 expression via a positive IKKβ-IκBα-dependent NF-κB pathway and negative MKK3/6-p38α/β and MEKK1-MKK4/7-JNK1/2 signaling pathways. Glucocorticoids synergistically enhance IL-1β-induced TLR2 expression via up-regulation of MKP-1 that, in turn, leads to dephosphorylation and inactivation of p38 and JNK pathways, the negative regulators for TLR2 expression. Abbreviations: DEX, dexamethasone; GR, glucocorticoids receptor; IκBα, Inhibitor of NF-κBα ; IKKβ, IκB kinase β ; IL-1β, interleukin 1 β ; JNK, c-Jun N-terminal kinase;MAPK, mitogen-activated protein kinase; MKK, MAPK kinase; MEKK1, MAPK/Erk kinase kinase 1; MKP-1, MAP kinase phosphatase-1; NF-κB, nuclear factor κB; TLR2, Toll-like receptor 2.

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BMC Molecular Biology

ISSN: 1471-2199

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