Figure 2
From: L1CAM expression in endometrial carcinomas is regulated by usage of two different promoter regions
In silico characterisation of the L1CAM promoter. (A) Schematic illustration of the L1CAM promoter region according to the Ensembl database. Exon 1 contains the translational start codon (ATG) and a transcription start sites (TSS) predicted by the indicated databeses DOOP, CAGE, DBTSS, MBPromDB. The upstream sequence of appr. 4100 bp was identified as promoter 2. The non-coding Exon 0 (82 bp) is located appr. 10 kb upstream and is followed by an appr. 4.5 kb promoter region (promoter 1). A second TSS is predicted by the program CAGE. (B) Schematic illustration of E-boxes and TCF/LEF-1 binding sites in promoter 1 and promoter 2. (C) DNA sequences of E-boxes and Lef-1 transcription factor binding sites in promoter 1 and promoter 2.