In silico characterisation of the L1CAM promoter. (A) Schematic illustration of the L1CAM promoter region according to the Ensembl database. Exon 1 contains the translational start codon (ATG) and a transcription start sites (TSS) predicted by the indicated databeses DOOP, CAGE, DBTSS, MBPromDB. The upstream sequence of appr. 4100 bp was identified as promoter 2. The non-coding Exon 0 (82 bp) is located appr. 10 kb upstream and is followed by an appr. 4.5 kb promoter region (promoter 1). A second TSS is predicted by the program CAGE. (B) Schematic illustration of E-boxes and TCF/LEF-1 binding sites in promoter 1 and promoter 2. (C) DNA sequences of E-boxes and Lef-1 transcription factor binding sites in promoter 1 and promoter 2.