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Table 1 Main putative transcription factor binding sites found in the ACVRL1 promoter region

From: Characterization of the human Activin-A receptor type II-like kinase 1 (ACVRL1) promoter and its regulation by Sp1

Family

Start pos.

End pos.

Str.

Matrix sim.

Core sim.

Family

Start pos.

End pos.

Str.

Matrix sim.

Core sim.

AP1

-875

-855

-

0.823

1.0

HIF

-808

-792

+

0.85

0.9

 

-873

-853

+

0.899

0.813

 

-286

-274

+

0.885

1.0

 

-871

-851

-

0.994

1.0

 

-236

-219

-

0.843

0.75

AP4

-881

-865

-

0.923

1.0

NFKB

-851

-839

+

0.901

1.0

 

-820

-804

-

0.87

0.882

 

-786

-774

+

0.852

1.0

 

-506

-490

-

0.961

1.0

 

-784

-772

-

0.919

1.0

 

+179

+195

-

0.855

1.0

 

-534

-522

+

0.985

1.0

CEBP

-432

-418

+

0.945

0.971

 

-533

-521

-

0.947

1.0

EKLF/KLF1

-918

-902

-

0.924

1.0

 

-220

-208

+

0.84

1.0

 

-886

-870

-

0.911

1.0

 

-158

-146

+

0.838

1.0

 

-808

-792

+

0.975

1.0

RXR

-979

-955

+

0.954

1.0

 

-737

-721

+

0.932

1.0

 

-871

-847

+

0.758

0.771

 

-731

-715

+

0.917

1.0

 

-864

-840

+

0.818

0.824

 

-433

-417

+

0.977

1.0

 

-535

-511

+

0.847

0.952

 

-410

-394

-

0.933

1.0

 

-441

-417

+

0.763

0.812

 

-405

-389

-

0.95

1.0

 

-314

-290

-

0.819

0.81

 

-313

-297

-

0.974

1.0

 

-230

-206

-

0.791

0.905

 

-241

-225

-

0.916

1.0

SMAD

-270

-262

+

0.969

1.0

 

-107

-91

+

0.923

1.0

SP1

-919

-905

-

0.901

0.807

 

-73

-57

+

0.916

1.0

 

-810

-796

+

0.885

0.872

 

-68

-52

+

0.971

1.0

 

-734

-720

+

0.997

1.0

 

+125

+141

-

0.947

1.0

 

-728

-714

+

0.879

1.0

ETS

-939

-919

+

0.961

1.0

 

-524

-510

+

0.913

1.0

 

-797

-777

+

0.922

1.0

 

-435

-421

+

0.881

0.872

 

-791

-771

+

0.965

1.0

 

-411

-397

-

0.89

0.807

 

-758

-738

-

0.943

1.0

 

-401

-387

-

0.895

0.872

 

-699

-679

+

0.972

1.0

 

-309

-295

-

0.891

0.872

 

-388

-368

-

0.945

1.0

 

-184

-170

-

0.98

1.0

 

-373

-353

-

0.914

1.0

 

-88

-74

+

0.885

1.0

 

+36

+56

+

0.927

1.0

 

-70

-56

+

0.892

0.872

E2F

-493

-477

+

0.849

1.0

 

+15

+30

+

0.987

1.0

 

-143

-127

-

0.861

0.81

 

+124

+139

-

0.93

0.877

 

+98

+114

-

0.971

1.0

ZF9/KLF6

-815

-793

-

0.891

0.923

 

+99

+115

+

0.964

1.0

 

-739

-717

-

0.899

1.0

 

+150

+166

-

0.875

1.0

 

-148

-126

-

0.881

1.0

GKLF/KLF4

-981

-969

+

1.000

0.862

 

-109

-87

-

0.897

0.821

 

-600

-588

+

1.000

0.883

 

-86

-64

-

0.879

1.0

 

-3

+9

+

0.770

0.868

 

+150

+172

+

0.936

1.0

  1. Note: Start/End pos, starting/ending position of the consensus site in the sequence; Str, Strand-sense; Matrix sim, Matrix (groups of functionally similar transcription factors) similarity factor (0-1); Core sim, Core consensus sequence (4 highest conserved positions) similarity factor (0-1); AP1, Activator Protein 1; AP4, Activator Protein 4; CEBP, CCAAT/Enhancer Binding Protein; EKLF, Erythroid Krüppel-Like Factor; ETS, E26-Transformation-Specific transcription factor; E2F, Elongation Factor 2; GKLF, Gut-related Krüppel-Like Factor; HIF, Hypoxia Inducible Factor; NF?B, Nuclear Factor of kappa light polypeptide gene enhancer in B-cells; RXR, Retinoid X Receptor; SMAD, Sma and Mad-related; SP1, Specificity Protein 1; ZF9, Krüppel-like Zinc Finger protein 9.
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BMC Molecular Biology

ISSN: 1471-2199

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