Figure 3

Sequence alignment of the human ACVRL1 TSSs across different mammalian species. (A) Scheme of the human sequences used for the alignment. The blue arrow indicates the previously described TSS (+ 1). The red arrows indicate the new TSSs identified in Figure 1. (B) Sequences from chimpanzee, orangutan, rhesus monkey, cow, dog, horse, mouse and rat were compared with the human -1,035/+210 sequence. Sequences were obtained from NCBI-GenBank and EMBL databases (see Methods). Asterisks indicate the totally conserved residues across species. Alignments of the putative regulatory sites are shown with a colored background based on the identity between species. The degree of homology is: black > dark grey > light grey. Score means percentage of identity with the human sequence. Brackets indicate exonic sequences.