Figure 4

The effects of antisense transcription from C14orf167 on the transcriptional regulation of the DHRS4 gene cluster. (1) Bidirectional transcription of C14orf167 inhibits the initiation of the DHRS4 transcription through impeding the binding of RNA polymerase II and transcriptional factors to DHRS4. (2) The antisense RNAs from C14orf167 match with exon 1 in the primary transcripts initiated from exon a1/a2, and possibly resulting in the removing of exon 1 in the spliced RNAs. DHRS4L2 and DHRS4L1 are under the same condition to C14orf167 RNAs.