Figure 1

The Bach2 locus and proviral integration sites. Structures of genes, exons, and distances between insertion sites are not shown in scale. (A) Schematic description of the mouse chromosome 4 region around the Bach2 locus. The transcriptional orientation of the genes is indicated by arrows. (B) Illustration of the Bach2 gene. The exons are shown with solid bars, with un-translated regions in grey and the coding sequences in black. The dashed lines indicate the location of Bach2 protein domains, BTB and bZip. (C) Illustration of the localization of proviral insertions in the Bach2 gene. Position and transcriptional orientation of the proviruses are shown by triangles and were confirmed by gene-specific PCRs. The proviruses are named after the integration order from left to right at the locus, with s1 being the first integration site and s18 the last. For the proviruses located in intron 2, distances away from the nearest upstream proviral integration site are shown in brackets in base pairs.