Transcriptional control of gene expression

Section edited by Jean-Francois Beaulieu

This section will consider submissions that focus on the analysis of gene expression levels and patterns, transcription mechanisms and the regulation of transcription.

Previous Page Page 1 of 3 Next Page
  1. Research article

    Properties of STAT1 and IRF1 enhancers and the influence of SNPs

    STAT1 and IRF1 collaborate to induce interferon-γ (IFNγ) stimulated genes (ISGs), but the extent to which they act alone or together is unclear. The effect of single nucleotide polymorphisms (SNPs) on in vivo ...

    Mohamed Abou El Hassan, Katherine Huang, Manoja B. K. Eswara, Zhaodong Xu, Tao Yu, Arthur Aubry, Zuyao Ni, Izzy Livne-bar, Monika Sangwan, Mohamad Ahmad and Rod Bremner

    BMC Molecular Biology 2017 18:6

    Published on: 9 March 2017

  2. Research article

    Identification of microRNAs and their response to the stress of plant allelochemicals in Aphis gossypii (Hemiptera: Aphididae)

    MicroRNAs (miRNAs) are a group of short non-coding RNAs involved in the inhibition of protein translation or in mRNA degradation. Although the regulatory roles of miRNAs in various biological processes have be...

    Kang-Sheng Ma, Fen Li, Ying Liu, Ping-Zhuo Liang, Xue-Wei Chen and Xi-Wu Gao

    BMC Molecular Biology 2017 18:5

    Published on: 16 February 2017

  3. Research article

    Binding affinity of five PBPs to Ostrinia sex pheromones

    Pheromone binding proteins (PBPs) of male Lepidoptera function in chemical communication, mate attraction and recognition. Directional selection was previously predicted between PBP3 orthologs of Ostrinia furnaca...

    Tiantao Zhang, Yaqi Sun, Kevin W. Wanner, Brad S. Coates, Kanglai He and Zhenying Wang

    BMC Molecular Biology 2017 18:4

    Published on: 7 February 2017

  4. Research article

    Transcriptional regulation of human sperm-associated antigen 16 gene by S-SOX5

    The mammalian sperm-associated antigen 16 gene (Spag16) uses alternative promoters to produce two major transcript isoforms (Spag16L and Spag16S) and encode proteins that are involved in the cilia/flagella format...

    Ling Zhang, Yunhao Liu, Wei Li, Qiaoling Zhang, Yanwei Li, Junpin Liu, Jie Min, Chaofan Shuang, Shizheng Song and Zhibing Zhang

    BMC Molecular Biology 2017 18:2

    Published on: 31 January 2017

  5. Research article

    RNA polymerase II depletion promotes transcription of alternative mRNA species

    Cells respond to numerous internal and external stresses, such as heat, cold, oxidative stress, DNA damage, and osmotic pressure changes. In most cases, the primary response to stress is transcriptional induct...

    Lijian Yu, Mayuri Rege, Craig L. Peterson and Michael R. Volkert

    BMC Molecular Biology 2016 17:20

    Published on: 30 August 2016

  6. Research article

    Stearoyl-CoA desaturase 1 expression is downregulated in liver and udder during E. coli mastitis through enhanced expression of repressive C/EBP factors and reduced expression of the inducer SREBP1A

    Stearoyl-CoA desaturase 1 (SCD1) desaturates long chain fatty acids and is therefore a key enzyme in fat catabolism. Its synthesis is downregulated in liver during illnesses caused by high levels of circulatin...

    Tianle Xu, Xiangzhen Shen and Hans-Martin Seyfert

    BMC Molecular Biology 2016 17:16

    Published on: 20 July 2016

  7. Research Article

    Confirmation of translatability and functionality certifies the dual endothelin1/VEGFsp receptor (DEspR) protein

    In contrast to rat and mouse databases, the NCBI gene database lists the human dual-endothelin1/VEGFsp receptor (DEspR, formerly Dear) as a unitary transcribed pseudogene due to a stop [TGA]-codon at codon#14 in ...

    Victoria L. M. Herrera, Martin Steffen, Ann Marie Moran, Glaiza A. Tan, Khristine A. Pasion, Keith Rivera, Darryl J. Pappin and Nelson Ruiz-Opazo

    BMC Molecular Biology 2016 17:15

    Published on: 14 June 2016

  8. Methodology article

    A reliable method for quantification of splice variants using RT-qPCR

    The majority of protein isoforms arise from alternative splicing of the encoding primary RNA transcripts. To understand the significance of single splicing events, reliable techniques are needed to determine t...

    Julia Camacho Londoño and Stephan E. Philipp

    BMC Molecular Biology 2016 17:8

    Published on: 15 March 2016

  9. Research article

    Knockdown of SALL4 inhibits the proliferation and reverses the resistance of MCF-7/ADR cells to doxorubicin hydrochloride

    Breast cancer is the most frequent malignancy in women and drug resistance is the major obstacle for its successful chemotherapy. In the present study, we analyzed the involvement of an oncofetal gene, sal-lik...

    Yuan-Yuan Chen, Zhi-Zhen Li, Yuan-Yuan Ye, Feng Xu, Rui-Jie Niu, Hong-Chen Zhang, Yi-Jian Zhang, Ying-Bin Liu and Bao-San Han

    BMC Molecular Biology 2016 17:6

    Published on: 2 March 2016

  10. Research article

    Transfection of Sertoli cells with androgen receptor alters gene expression without androgen stimulation

    Androgens play an important role for the development of male fertility and gained interest as growth and survival factors for certain types of cancer. Androgens act via the androgen receptor (AR/Ar), which is inv...

    D. Fietz, M. Markmann, D. Lang, L. Konrad, J. Geyer, S. Kliesch, T. Chakraborty, H. Hossain and M. Bergmann

    BMC Molecular Biology 2015 16:23

    Published on: 29 December 2015

  11. Research article

    Conserved and highly expressed tRNA derived fragments in zebrafish

    Small non-coding RNAs (sncRNAs) are a class of transcripts implicated in several eukaryotic regulatory mechanisms, namely gene silencing and chromatin regulation. Despite significant progress in their identifi...

    Ana Raquel Soares, Noémia Fernandes, Marisa Reverendo, Hugo Rafael Araújo, José Luís Oliveira, Gabriela M. R. Moura and Manuel A. S. Santos

    BMC Molecular Biology 2015 16:22

    Published on: 22 December 2015

  12. Research article

    Temperature-induced variation in gene expression burst size in metazoan cells

    Gene expression is an inherently stochastic process, owing to its dynamic molecular nature. Protein amount distributions, which can be acquired by cytometry using a reporter gene, can inform about the mechanis...

    Ophélie Arnaud, Sam Meyer, Elodie Vallin, Guillaume Beslon and Olivier Gandrillon

    BMC Molecular Biology 2015 16:20

    Published on: 25 November 2015

    The Erratum to this article has been published in BMC Molecular Biology 2016 17:2

  13. Research article

    Analysis artefacts of the INS-IGF2 fusion transcript

    In gene expression analysis, overlapping genes, splice variants, and fusion transcripts are potential sources of data analysis artefacts, depending on how the observed intensity is assigned to one, or more gen...

    Rasmus Wernersson, Thomas Frogne, Claude Rescan, Lena Hansson, Christine Bruun, Mads Grønborg, Jan Nygaard Jensen and Ole Dragsbæk Madsen

    BMC Molecular Biology 2015 16:13

    Published on: 29 July 2015

  14. Research article

    Establishment of a quantitative PCR system for discriminating chitinase-like proteins: catalytically inactive breast regression protein-39 and Ym1 are constitutive genes in mouse lung

    Mice and humans produce chitinase-like proteins (CLPs), which are highly homologous to chitinases but lack chitinolytic activity. Mice express primarily three CLPs, including breast regression protein-39 (BRP-...

    Misa Ohno, Yuta Kida, Masayoshi Sakaguchi, Yasusato Sugahara and Fumitaka Oyama

    BMC Molecular Biology 2014 15:23

    Published on: 8 October 2014

Previous Page Page 1 of 3 Next Page

Can't find what you are looking for?

Articles for this section are still being added to this new-look site. In the meantime you can still view this section on our old site.