Table 2 The EE-elements in clock and clock-controlled genes. Clock and clock-controlled genes containing putative EE-elements (A; [28], B; [29], C; [30]). "Phase" means peak time. Phase 2, the peak value = CT 0.1~4.0; phase 6, CT 4.1~8.0; phase 10, CT 8.1~12; phase 14, CT 12.1~16; phase 18, CT 16.1~20; phase 22, CT 20.1~24. "pos" indicates the position of the EE-element from the TSS. Underlines indicate nucleotides matched to the canonical E-box.
Paper | Organ | Phase | Gene | pos | mouse | human | ||
|---|---|---|---|---|---|---|---|---|
| Â | Â | Â | Â | Â | sequence | sp | sequence | sp |
A | SCN | 10 | Per2 | -23 | CACGT TTTCCACTA TGTG | 6 | CACGTTTTCCACTA TGTG | 6 |
A | Liver | 14 | Â | -23 | Â | Â | Â | Â |
B | Liver | 14 | Â | -23 | Â | Â | Â | Â |
B | Heart | 10 | Â | -23 | Â | Â | Â | Â |
C | SCN | 10 | Â | -23 | Â | Â | Â | Â |
C | Liver | 14 | Â | -23 | Â | Â | Â | Â |
A | SCN | 18 | Nr1d1 | -878 | CACGTG AAGCTCTCACGT T | 7 | CACGTG AAGCCCTCACGT T | 7 |
A | Liver | 6 | Â | -878 | Â | Â | Â | Â |
B | Liver | 6 | Â | -878 | Â | Â | Â | Â |
B | Heart | 6 | Â | -878 | Â | Â | Â | Â |
C | Liver | 6 | Â | -878 | Â | Â | Â | Â |
B | Liver | 6 | Dbp | -606 | CACG CG CAAAGCCA TGTG | 6 | CACG AG CAGAGCCA TGTG | 6 |
B | Heart | 10 | Â | -606 | Â | Â | Â | Â |
C | SCN | 6 | Â | -606 | Â | Â | Â | Â |
B | Liver | 10 | Tef | -529 | CACGTG CAGAGCC TCGTG | 6 | CACG TGCGGCGCC TCGTG | 6 |
B | Liver | 10 | Â | -208 | CAC CTG GCCCAGCACGTG | 6 | CAC CTG GCCCCGCACGTG | 6 |
B | Heart | 10 | Â | -529 | Â | Â | Â | Â |
B | Heart | 10 | Â | -208 | Â | Â | Â | Â |
A | Liver | 10 | Foxo3a | -97 | CACG CG CACTCCCAC ACG | 6 | CACG CG CACTCACAC ACG | 6 |
B | Liver | 10 | Â | -97 | Â | Â | Â | Â |
C | Liver | 10 | Â | -97 | Â | Â | Â | Â |
A | Liver | 10 | 3732413I11Rik | -307 | CACGTG GTCCCAGCA GGTG | 7 | CACGTG GTCCCTGCA GGTG | 7 |
C | Liver | 10 | Â | -307 | Â | Â | Â | Â |
A | Liver | 18 | Tfdp1 | -916 | CACGT CACCGCGCC GCG CG | Â | CACGT CACCGCGCC GCG CG | 7 |
B | Liver | 14 | Â | -916 | Â | Â | Â | Â |
B | Liver | 18 | Tfrc | -127 | TACGTG CGGAAGGA AGTG | 6 | TACGTG CCTCAGGA AGTG | 6 |
B | Heart | 2 | Â | -127 | Â | Â | Â | Â |
B | Liver | 22 | Sox3 | -200 | CA GGTG AGAGAAGC CCG CG | 7 | CA GGTG CGAGAAGC CCG CG | 7 |
B | Heart | 18 | Â | -200 | Â | Â | Â | Â |
B | Heart | 2 | MGI:1351465 | -387 | CACG GG CCCCACC TTGTG | 6 | CACG GG CCCCACC TTGTG | 6 |
C | SCN | 6 | Avp | -186 | CACGTG TGTCCCCA GATG | 6 | CACGTG TGTCCCCA GATG | 6 |
A | SCN | 14 | Serpine1 | -179 | CACGTG TCCCAGCA AGT C | 6 | CAC ATG CCTCAGCA AGT C | 6 |
B | Liver | 6 | Wwp2 | -33 | CACGTG ACCCGGC CCG AG | 6 | CACGTG ACCCGGC CCG AG | 6 |
C | SCN | 18 | Hnrpm | -42 | CACGTG AGCGCGCA GG CG | 6 | CACGTG GGCGCGCA GG CG | 6 |
B | Heart | 6 | Snx2 | -41 | CACGTG ACAGGTCC GCG AG | 7 | CACGTG ACGGGTCC GCG AG | 7 |
A | SCN | 18 | Spag7 | -238 | CACG AG CACTTTCTAC TTG | 7 | CACG GG CACTTTCTAC TTG | 7 |
A | SCN | 10 | Pabpn1 | -438 | CAC CTG TCGCACAACG GG | 6 | CAC CTG TCACGAAACG AG | 6 |
B | Heart | 18 | Zic2 | -415 | CA GGTG GAGCGGC GGGTG | 6 | CA GGTG GAGCCGC TGGTG | 6 |
A | SCN | 18 | Cacna2d3 | -37 | CA AGTG AGCCGGGC GCG CG | 7 | CA AGTG AGCCGGGC GCG CG | 7 |
A | SCN | 10 | Cog8 | -705 | CACGTG CAAGCGGAAC TTG | 7 | GAC GTG CAACCGAAAC TTG | 7 |
B | Heart | 2 | Col4a2 | -641 | CAC CTG GCCGTGCCAC CCG | 7 | CAC CTG GCCGTGCCACG CG | 7 |
C | SCN | 14 | Ube2s | -117 | AACGTG CGCGTTGACGT A | 6 | AACGTG CGCGCTGACGT C | 6 |
A | SCN | 10 | Igsf4a | -584 | GACGTG CAAAGCAC GC ATG | 7 | GACGTG CAAAGCAC GC ATG | 7 |
C | SCN | 18 | Plekha1 | -31 | C GCGTG CGCAGTGC GCG GG | 7 | C GCGTG CGCAGTGC GCG GG | 7 |
B | Heart | 2 | Qk | -352 | C CCGTG GGTGCGCACG CG | 6 | C CCGTG GGTGCGCACG CG | 6 |
C | SCN | 6 | Rexo2 | -27 | C CCGTG GGTTTGCGACGT T | 7 | C CCGTG GGTTTGCGACGT T | 7 |
B | Liver | 10 | Trfp | -683 | C GCGTG GCGCGCTC TCG CG | 7 | C GCGTG GTGCGTTC CCG CG | 7 |
C | Liver | 18 | BC014685 | -186 | C CCGTG ACATTGCC GCG GG | 7 | C CCGTG ACGCGGGC GCG GG | 7 |
B | Heart | 2 | Ptma | -23 | C GCGTG AGTCCCCCAC TGG | 7 | C GCGTG AGTCCCCCAC TGG | 7 |