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Table 1 The criteria for the EE-element. Criteria for the EE-element are as follow: 1) 2 E-boxes, close to each other, are needed, 2) E1 E-box allows 1 base mismatch, E2 E-box allows 2 base mismatches, 3) the spacing between 2 E-boxes is 6 or 7 bp, and 4) the element is located within 1 kb upstream region from the TSS.

From: A direct repeat of E-box-like elements is required for cell-autonomous circadian rhythm of clock genes

E-box

space

E-box

C A C G T G

6 or 7 bp

C A C G T G

0~1 mismatch

 

0~2 mismatch