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Figure 2 | BMC Molecular Biology

Figure 2

From: A direct repeat of E-box-like elements is required for cell-autonomous circadian rhythm of clock genes

Figure 2

Effects of EE-element mutants on circadian expression of luciferase. (A) Wild-type (upper, gray letters) and mutant (bottom, black letters) sequences of hPer2 E1 and E2 and their flanking sequences are shown. Underlines indicate sequences changed from the wild-type one. The core sequence within the EE-element is shown in capital letters. (B) EE-element-driven luciferase bioluminescence by IV-ROMS. Gray lines indicate bioluminescence of wild-type hPer2 EE-element; and black lines, those of mutants. The abscissa presents "day", and the ordinate indicates "relative luciferase intensity". First peak values of the curves were set to 1.

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BMC Molecular Biology

ISSN: 1471-2199

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