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Figure 1 | BMC Molecular Biology

Figure 1

From: A direct repeat of E-box-like elements is required for cell-autonomous circadian rhythm of clock genes

Figure 1

The "EE-element" possesses transcriptional activity displaying a circadian rhythm. (A) Sequence alignments of the promoter region, containing each EE-element of Per1, Per2 and Per3 gene, among human, rhesus, rat, mouse and opossum (The NCBI accession numbers are indicated in Additional file 6). The core sequences (E1 and E2) within the EE-element are shown in capital letters. Numbers at both sides of alignments indicate the position from the transcription start site (TSS). (B) EE-element-driven luciferase bioluminescence by IV-ROMS. Black lines indicate bioluminescence after serum shock; and gray lines show the negative control (replacement with same medium). Abscissa presents "day"; and ordinate, "relative luciferase intensity". First peak values of the curves were set to 1.

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BMC Molecular Biology

ISSN: 1471-2199

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