Figure 3

Spatial proximity of the three specific insertions and specifically-accessible hydrophobic surface in the RdCVF-S and RdCVF2-S proteins. Panel a displays the space-filling representation of RdCVF-L (left) and RdCVF2-L (right) using the same color code as Figure 2 panel b. Importantly, the RdCVF(2)-L models were rotated as indicated to focus on the three specific insertions. Note that catalytic site and "cap" region are on opposite ends of the protein. Panel b shows the RdCVF-S and RdCVF2-S models. Hydrophobic, small, polar and charged residues are colored in yellow, green, blue and red respectively. The models were rotated to focus on the large hydrophobic surface specifically-accessible in the short isoforms.