Skip to main content
Figure 1 | BMC Molecular Biology

Figure 1

From: Spdef deletion rescues the crypt cell proliferation defect in conditional Gata6 null mouse small intestine

Figure 1

Overlap of genes in small intestine modulated by conditional Gata6 or Spdef knockout. (A) Publicly available gene profiling data from conditional Gata6 (GSE22416) and Spdef (GSE14892) knockout mouse intestine show a significant overlap. (B) Functional annotation clustering of pathways shows that the top-enriched cluster, in overlapping Gata6 and Spdef genes, contains the Wnt pathway as its main function (ES score 2.58). (C) GSEA analysis shows, in the overlapping Gata6 and Spdef gene segment, APC targets as the second most highly enriched cluster (ES score 1.57).

Back to article page

BMC Molecular Biology

ISSN: 1471-2199

Contact us