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Figure 7 | BMC Molecular Biology

Figure 7

From: Interaction of ZEB and Histone Deacetylase with the PLDLS-binding cleft region of monomeric C-terminal Binding Protein 2

Figure 7

Model for HDAC-dependent transcriptional repression by CtBP2. A, Interaction of HDAC1/2 and ZEB with CtBP2 monomer. Based our on results we suggest that HDAC1/2 interact with CtBP2 sequences that encompass the hydrophobic cleft (PLDLS-binding) region and additional regions such as the NTR, while ZEB and other PLDLS-motif containing transcription factors interact exclusively with the cleft region. Our results suggest that interaction of the CtBP2 monomer with HDAC1/2 and the PLDLS-motif factors is mutually exclusive. B, Transcriptional repression by CtBP2. We propose that recruitment of CtBP2 with the DNA-bound PLDLS-motif containing repressor via one monomer of the CtBP2 dimer might facilitate recruitment of HDAC1/2 via the second CtBP2 monomer.

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BMC Molecular Biology

ISSN: 1471-2199

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