Loss of the insulator protein CTCF during nematode evolution

BMC Molecular Biology

Table 1 BLAST results for insulator protein searches in nematode genomes

	Su(Hw)	BEAF-32	GAGA	Zw5	CTCF
C. elegans	134	-	52	132	124
	125		42	129	106
Clade 9	113		42	128	100
C. briggsae	133	-	43	136	107
	117		42	128	105
Clade 9	114		39	125	101
C. remanei	134	-	53	129	131
	127		47	128	107
Clade 9	119		47	125	103
P. pacificus	69	32	31	73	60
	69	32	31	73	59
Clade 9	63	-	30	68	56
A. suum	75	-	40	76	56
	67		35	71	55
Clade 8	63		34	62	49
B. malayi	178	-	37	197	192
	174		37	197	181
Clade 8	173		36	196	181
T. spiralis	134	30	45	146	408
	116	29	40	134	141
Clade 2	105	-	33	105	107

Results of BLAST searches for five known insulator proteins in seven nematode genomes (clade numbering after [24], see Figure 4A). Numbers represent the reported BLASTP score of the three best hits in a given genome. Only CTCF can be detected in the basal nematode T. spiralis (bold). See text for further explanation.

ISSN: 1471-2199