https://bmcmolbiol.biomedcentral.com/articles/10.1186/s12867-016-0071-y https://bmcmolbiol.biomedcentral.com/articles/10.1186/s12867-016-0073-9 https://bmcmolbiol.biomedcentral.com/articles/10.1186/s12867-016-0072-x https://bmcmolbiol.biomedcentral.com/articles/10.1186/s12867-016-0074-8