https://bmcmolbiol.biomedcentral.com/articles/10.1186/s12867-016-0064-x
https://bmcmolbiol.biomedcentral.com/articles/10.1186/s12867-016-0061-0
https://bmcmolbiol.biomedcentral.com/articles/10.1186/s12867-016-0063-y