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Page 9 of 17

  1. The TetR family member AmtR is the central regulator of nitrogen starvation response in Corynebacterium glutamicum. While the AmtR regulon was physiologically characterized in great detail up to now, mechanistic ...

    Authors: Daniela Muhl, Nadja JeĂźberger, Kristin Hasselt, Christophe Jardin, Heinrich Sticht and Andreas Burkovski
    Citation: BMC Molecular Biology 2009 10:73
  2. Heart and lung transplantation is frequently the only therapeutic option for patients with end stage cardio respiratory disease. Organ donation post brain stem death (BSD) is a pre-requisite, yet BSD itself ca...

    Authors: Margaret Passmore, Maria Nataatmadja and John F Fraser
    Citation: BMC Molecular Biology 2009 10:72
  3. RT-qPCR is a preferred method for rapid and reliable quantification of gene expression studies. Appropriate application of RT-qPCR in such studies requires the use of reference gene(s) as an internal control t...

    Authors: Zhaoguo Tong, Zhihong Gao, Fei Wang, Jun Zhou and Zhen Zhang
    Citation: BMC Molecular Biology 2009 10:71
  4. Quantitative real-time polymerase chain reaction (RT-qPCR) is valuable for studying the molecular events underlying physiological and behavioral phenomena. Normalization of real-time PCR data is critical for a...

    Authors: Maria Sirakov, Ilaria Zarrella, Marco Borra, Francesca Rizzo, Elio Biffali, Maria Ina Arnone and Graziano Fiorito
    Citation: BMC Molecular Biology 2009 10:70
  5. Laser capture microdissection enables the isolation of single cells or small cell groups from histological sections under direct microscopic observation. Combined with quantitative PCR or microarray, it is a v...

    Authors: Wei-Zhi Wang, Franziska M Oeschger, Sheena Lee and Zoltán Molnár
    Citation: BMC Molecular Biology 2009 10:69
  6. The choroid plexus consists of highly differentiated epithelium and functions as a barrier at the interface of the blood-cerebrospinal-fluid (CSF). This tissue may therefore determine the bioavailability and t...

    Authors: Monika Niehof and JĂĽrgen Borlak
    Citation: BMC Molecular Biology 2009 10:68
  7. Many mammalian genes are organized as bidirectional (head-to-head) gene pairs with the two genes separated only by less than 1 kb. The transcriptional regulation of these bidirectional gene pairs remains large...

    Authors: Chien-Chang Huang and Wun-Shaing Wayne Chang
    Citation: BMC Molecular Biology 2009 10:67
  8. Analysis of RNA expression using real-time PCR (qRT-PCR) traditionally includes reference genes (RG) as an internal control. This practice is being questioned as it becomes increasingly clear that RG may vary ...

    Authors: Jens Stern-Straeter, Gabriel A Bonaterra, Karl Hörmann, Ralf Kinscherf and Ulrich R Goessler
    Citation: BMC Molecular Biology 2009 10:66
  9. Germline specific promoters are an essential component of potential vector control strategies which function by genetic drive, however suitable promoters are not currently available for the main human malaria ...

    Authors: Philippos A Papathanos, Nikolai Windbichler, Miriam Menichelli, Austin Burt and Andrea Crisanti
    Citation: BMC Molecular Biology 2009 10:65
  10. Normalization is a prerequisite for accurate real time PCR (qPCR) expression analysis and for the validation of microarray profiling data in microbial systems. The choice and use of reference genes that are st...

    Authors: Pamela A Nieto, Paulo C Covarrubias, Eugenia Jedlicki, David S Holmes and Raquel Quatrini
    Citation: BMC Molecular Biology 2009 10:63
  11. Balanus amphitrite is a barnacle commonly used in biofouling research. Although many aspects of its biology have been elucidated, the lack of genetic information is impeding a molecular understanding of its life ...

    Authors: Tristano Bacchetti De Gregoris, Marco Borra, Elio Biffali, Thomas Bekel, J Grant Burgess, Richard R Kirby and Anthony S Clare
    Citation: BMC Molecular Biology 2009 10:62
  12. Claudins, a family of protein localized in tight junctions, are essential for the control of paracellular permeation in epithelia and endothelia. The interaction of several claudins with Clostridium perfringens e...

    Authors: Dörte Lohrberg, Eberhard Krause, Michael Schümann, Jörg Piontek, Lars Winkler, Ingolf E Blasig and Reiner F Haseloff
    Citation: BMC Molecular Biology 2009 10:61
  13. Termination of translation in eukaryotes is controlled by two interacting polypeptide chain release factors, eRF1 and eRF3. While eRF1 recognizes nonsense codons, eRF3 facilitates polypeptide chain release fro...

    Authors: Igor A Valouev, Gleb V Fominov, Elizaveta E Sokolova, Vladimir N Smirnov and Michael D Ter-Avanesyan
    Citation: BMC Molecular Biology 2009 10:60
  14. The human Sex Hormone Binding Globulin (SHBG) gene, located at 17p13.1, comprises, at least, two different transcription units regulated by two different promoters. The first transcription unit begins with the...

    Authors: Tomàs Pinós, Anna Barbosa-Desongles, Antoni Hurtado, Albert Santamaria-Martínez, Inés de Torres, Joan Morote, Jaume Reventós and Francina Munell
    Citation: BMC Molecular Biology 2009 10:59
  15. Herpes Simplex Virus (HSV-1) gene expression is thought to shut off recombinant gene expression from HSV-1 vectors; however, in a helper virus-free HSV-1 vector system, a number of promoters support only short...

    Authors: Meng Liu, Xiaodan Wang and Alfred I Geller
    Citation: BMC Molecular Biology 2009 10:58
  16. Studies of gene expression in experimental cerebral ischaemia models can contribute to understanding the pathophysiology of brain ischaemia and to identifying prognostic markers and potential therapeutic targe...

    Authors: Carme Gubern, Olivia Hurtado, RocĂ­o RodrĂ­guez, JesĂşs R Morales, VĂ­ctor G Romera, MarĂ­a A Moro, Ignacio Lizasoain, JoaquĂ­n Serena and Judith Mallolas
    Citation: BMC Molecular Biology 2009 10:57
  17. To obtain reliable quantitative RT-PCR data, normalization relative to stable housekeeping genes is required. However, in practice, expression levels of 'typical' housekeeping genes have been found to vary bet...

    Authors: Matthias B Van Hiel, Pieter Van Wielendaele, Liesbet Temmerman, Sofie Van Soest, Kristel Vuerinckx, Roger Huybrechts, Jozef Vanden Broeck and Gert Simonet
    Citation: BMC Molecular Biology 2009 10:56
  18. Modulation of chromatin structure has emerged as a critical molecular device to control gene expression. Histones undergo different post-translational modifications that increase chromatin accessibility to a n...

    Authors: Sabrina Pinato, Cristina Scandiuzzi, Nadia Arnaudo, Elisabetta Citterio, Giovanni Gaudino and Lorenza Penengo
    Citation: BMC Molecular Biology 2009 10:55
  19. Genomic studies measuring transcriptional responses to changing environments and stress currently make their way into the field of evolutionary ecology and ecotoxicology. To investigate a small to medium numbe...

    Authors: Muriel E de Boer, Tjalf E de Boer, Janine Mariën, Martijn JTN Timmermans, Benjamin Nota, Nico M van Straalen, Jacintha Ellers and Dick Roelofs
    Citation: BMC Molecular Biology 2009 10:54
  20. Restriction-modification systems are a diverse class of enzymes. They are classified into four major types: I, II, III and IV. We have previously proposed the existence of a Thermus sp. enzyme family, which belon...

    Authors: Agnieszka Zylicz-Stachula, Janusz M Bujnicki and Piotr M Skowron
    Citation: BMC Molecular Biology 2009 10:52

    The Erratum to this article has been published in BMC Molecular Biology 2014 15:16

  21. We present here an extensive epigenetic analysis of a 500 kb region, which encompasses the human desmin gene (DES) and its 5' locus control region (LCR), the only muscle-specific transcriptional regulatory elemen...

    Authors: Marianne Lindahl Allen, Christoph M Koch, Gayle K Clelland, Ian Dunham and Michael Antoniou
    Citation: BMC Molecular Biology 2009 10:51
  22. Through the whole life of eukaryotes, autophagy plays an important role in various biological events including development, differentiation and determination of lifespan. A full set of genes and their encoded ...

    Authors: Xuan Zhang, Zhan-Ying Hu, Wei-Fang Li, Qing-Rong Li, Xiao-Juan Deng, Wan-Ying Yang, Yang Cao and Cong-Zhao Zhou
    Citation: BMC Molecular Biology 2009 10:50
  23. The upgrading of rapeseed cultivars has resulted in a substantial improvement in yield and quality in China over the past 30 years. With the selective pressure against fatty acid composition and oil content, h...

    Authors: Yaping Hu, Gang Wu, Yinglong Cao, Yuhua Wu, Ling Xiao, Xiaodan Li and Changming Lu
    Citation: BMC Molecular Biology 2009 10:49
  24. Histone synthesis in Leishmania is tightly coupled to DNA replication by a post-transcriptional mechanism operating at the level of translation.

    Authors: Daniel R Abanades, Laura Ramírez, Salvador Iborra, Ketty Soteriadou, Victor M González, Pedro Bonay, Carlos Alonso and Manuel Soto
    Citation: BMC Molecular Biology 2009 10:48
  25. Conserved two-component system ColRS of Pseudomonas genus has been implicated in several unrelated phenotypes. For instance, deficiency of P. putida ColRS system results in lowered phenol tolerance, hindrance of ...

    Authors: Paula A Kivistik, Rait Kivi, Maia Kivisaar and Rita Hõrak
    Citation: BMC Molecular Biology 2009 10:46
  26. Sleep is a restorative process and is essential for maintenance of mental and physical health. In an attempt to understand the complexity of sleep, multidisciplinary strategies, including genetic approaches, h...

    Authors: Kil S Lee, Tathiana A Alvarenga, Camila Guindalini, Monica L Andersen, Rosa MRPS Castro and Sergio Tufik
    Citation: BMC Molecular Biology 2009 10:45
  27. Trypsin-like serine proteases are involved in a large number of processes including digestive degradation, regulation of developmental processes, yolk degradation and yolk degradome activation. Trypsin like pe...

    Authors: Rasmus Skern-Mauritzen, Petter Frost, Sussie Dalvin, Bjørn Olav Kvamme, Ingunn Sommerset and Frank Nilsen
    Citation: BMC Molecular Biology 2009 10:44
  28. Among the three functions of DNA, mammalian replication and transcription can be subject to epigenetic imprinting specified by the parental origin of chromosomes, and although there is suggestive indication th...

    Authors: Siemon H Ng, Rose Madeira, Emil D Parvanov, Lorin M Petros, Petko M Petkov and Kenneth Paigen
    Citation: BMC Molecular Biology 2009 10:43
  29. Oncogene HCCR-1 functions as a negative regulator of the p53 and contributes to tumorigenesis of various human tissues. However, it is unknown how HCCR-1 contributes to the cellular and biochemical mechanisms of ...

    Authors: Goang-Won Cho, Mi-Hwa Kim, Seung Hyun Kim, Seon-Ah Ha, Hyun Kee Kim, Sanghee Kim and Jin W Kim
    Citation: BMC Molecular Biology 2009 10:42
  30. The Wnt/β-catenin signaling pathway plays crucial roles in embryonic development and in maintenance of organs and tissues in adults. Chibby (Cby) is an evolutionarily conserved molecule that physically interac...

    Authors: Adaobi Mofunanya, Feng-Qian Li, Jen-Chih Hsieh and Ken-Ichi Takemaru
    Citation: BMC Molecular Biology 2009 10:41
  31. The serine protease thrombin catalyzes fibrin clot formation by converting fibrinogen into fibrin. Additionally, thrombin stimulation leads to an activation of stimulus-responsive transcription factors in diff...

    Authors: Oliver G Rössler and Gerald Thiel
    Citation: BMC Molecular Biology 2009 10:40
  32. Acanthamoebae polyphaga Mimivirus (APM) is the largest known dsDNA virus. The viral particle has a nearly icosahedral structure with an internal capsid shell surrounded with a dense layer of fibrils. A Capsid pro...

    Authors: SaĂŻd Azza, Christian Cambillau, Didier Raoult and Marie Suzan-Monti
    Citation: BMC Molecular Biology 2009 10:39
  33. Dicer, Ago2 and TRBP are the minimum components of the human RNA-induced silencing complex (RISC). While Dicer and Ago2 are RNases, TRBP is the double-stranded RNA binding protein (dsRBP) that loads small inte...

    Authors: Sylvanne M Daniels, Carlos E Melendez-Peña, Robert J Scarborough, Aïcha Daher, Helen S Christensen, Mohamed El Far, Damian FJ Purcell, Sébastien Lainé and Anne Gatignol
    Citation: BMC Molecular Biology 2009 10:38
  34. Human sex hormone-binding globulin (SHBG) regulates free sex steroid concentrations in plasma and modulates rapid, membrane based steroid signaling. SHBG is encoded by an eight exon-long transcript whose expre...

    Authors: Atif M Nakhla, Daniel J Hryb, William Rosner, Nicholas A Romas, Zhaoying Xiang and Scott M Kahn
    Citation: BMC Molecular Biology 2009 10:37
  35. Induction of stem cell differentiation toward functional hepatocytes is hampered by lack of knowledge of the hepatocyte differentiation processes. The overall objective of this project is to characterize key s...

    Authors: Pakpoom Kheolamai and Alan J Dickson
    Citation: BMC Molecular Biology 2009 10:35
  36. Pantoea ananatis, a member of the Enterobacteriacea family, is a new and promising subject for biotechnological research. Over recent years, impressive progress in its application to L-glutamate production has be...

    Authors: Joanna I Katashkina, Yoshihiko Hara, Lyubov I Golubeva, Irina G Andreeva, Tatiana M Kuvaeva and Sergey V Mashko
    Citation: BMC Molecular Biology 2009 10:34
  37. The Male Specific Lethal (MSL) complex is enriched on the single X chromosome in male Drosophila cells and functions to upregulate X-linked gene expression and equalize X-linked gene dosage with XX females. The z...

    Authors: Kathleen A Worringer, Feixia Chu and Barbara Panning
    Citation: BMC Molecular Biology 2009 10:33
  38. Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) is the gold standard technique for mRNA quantification, but appropriate normalization is required to obtain reliable data. Normalization t...

    Authors: Alexandre Ho-Pun-Cheung, Caroline Bascoul-Mollevi, Eric Assenat, Florence Boissière-Michot, Frédéric Bibeau, Dominic Cellier, Marc Ychou and Evelyne Lopez-Crapez
    Citation: BMC Molecular Biology 2009 10:31
  39. The leukocyte common antigen related receptor (LAR) protein has been shown to modulate the signal transduction of a number of different growth factors, including insulin and insulin-like growth factor 1. Splic...

    Authors: Simon JM Welham, Adrian JL Clark and Andrew M Salter
    Citation: BMC Molecular Biology 2009 10:30
  40. MicroRNAs (miRNAs) are endogenously expressed small RNAs with a length of about 21 nt. MiRNAs silence their target genes at the post-transcriptional level. In plants, miRNAs play various developmental and phys...

    Authors: Botao Zhao, Liangfa Ge, Ruqiang Liang, Wei Li, Kangcheng Ruan, Hongxuan Lin and Youxin Jin
    Citation: BMC Molecular Biology 2009 10:29
  41. HAND2, a key regulator for the development of the sympathetic nervous system, is located on chromosome 4q33 in a head-to-head orientation with DEIN, a recently identified novel gene with stage specific expression...

    Authors: Harald Voth, André Oberthuer, Thorsten Simon, Yvonne Kahlert, Frank Berthold and Matthias Fischer
    Citation: BMC Molecular Biology 2009 10:28
  42. The homologous recombination (HR) pathway is vital for maintaining genomic integrity through the restoration of double-stranded breaks and interstrand crosslinks. The RAD51 paralogs (RAD51B, RAD51C, RAD51D, XR...

    Authors: Aaron M Gruver, Brian D Yard, Campbell McInnes, Changanamkandath Rajesh and Douglas L Pittman
    Citation: BMC Molecular Biology 2009 10:27
  43. The Arthropods are a diverse group of organisms including Chelicerata (ticks, mites, spiders), Crustacea (crabs, shrimps), and Insecta (flies, mosquitoes, beetles, silkworm). The cattle tick, Rhipicephalus (Booph...

    Authors: Sebastian Kurscheid, Ala E Lew-Tabor, Manuel Rodriguez Valle, Anthea G Bruyeres, Vivienne J Doogan, Ulrike G Munderloh, Felix D Guerrero, Roberto A Barrero and Matthew I Bellgard
    Citation: BMC Molecular Biology 2009 10:26
  44. Pseudomonas aeruginosa encodes a putative topoisomerase with sequence similarity to the eukaryotic type IB topoisomerase from Vaccinia virus. Residues in the active site are conserved, notably Tyr292 which would ...

    Authors: Teesta Jain, Benjamin J Roper and Anne Grove
    Citation: BMC Molecular Biology 2009 10:23